Enhancing oncolytic virotherapy by exosome-mediated microRNA reprograming of the tumour microenvironment
Victoria A. Jennings,
Reah Rumbold-Hall,
Gemma Migneco
et al.
Abstract:BackgroundThere has been limited success of cancer immunotherapies in the treatment of ovarian cancer (OvCa) to date, largely due to the immunosuppressive tumour microenvironment (TME). Tumour-associated macrophages (TAMs) are a major component of both the primary tumour and malignant ascites, promoting tumour growth, angiogenesis, metastasis, chemotherapy resistance and immunosuppression. Differential microRNA (miRNA) profiles have been implicated in the plasticity of TAMs. Therefore, delivering miRNA to TAMs… Show more
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