Anomaly detection systems based on artificial intelligence (AI) have demonstrated high performance and efficiency in a wide range of applications such as power plants and smart factories. However, due to the inherent reliance of AI systems on the quality of training data, they still demonstrate poor performance in certain environments. Especially in hazardous facilities with constrained data collection, deploying these systems remains a challenge. In this paper, we propose Generative Anomaly Detection using Prototypical Networks (GAD-PN) designed to detect anomalies using only a limited number of normal samples. GAD-PN is a structure that integrates CycleGAN with Prototypical Networks (PNs), learning from metadata similar to the target environment. This approach enables the collection of data that are difficult to gather in real-world environments by using simulation or demonstration models, thus providing opportunities to learn a variety of environmental parameters under ideal and normal conditions. During the inference phase, PNs can classify normal and leak samples using only a small number of normal data from the target environment by prototypes that represent normal and abnormal features. We also complement the challenge of collecting anomaly data by generating anomaly data from normal data using CycleGAN trained on anomaly features. It can also be adapted to various environments that have similar anomalous scenarios, regardless of differences in environmental parameters. To validate the proposed structure, data were collected specifically targeting pipe leakage scenarios, which are significant problems in environments such as power plants. In addition, acoustic ultrasound signals were collected from the pipe nozzles in three different environments. As a result, the proposed model achieved a leak detection accuracy of over 90% in all environments, even with only a small number of normal data. This performance shows an average improvement of approximately 30% compared with traditional unsupervised learning models trained with a limited dataset.