Enhancing mixing efficiency in curved channels: A 3D study of bi-phasic Dean-Taylor flow with high spatial and temporal resolution

Pinho, Bruno; Williams, Lindsay M.; Mahin, Julien; Gao, Yunhu; Torrente‐Murciano, Laura

doi:10.1016/j.cej.2023.144342

Cited by 2 publications

(1 citation statement)

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“…After the catalyst Amberlyst-15 resin was packed in the PTFE coil, the interspace between the particles fabricated micro-curved channels that easily induced turbulence and achieved the formation of Dean vortices due to the flow instability even at relatively low values of Re . − The velocity was enormously improved from 8.75 × 10 –4 to 87.5 × 10 –4 m/s by altering the addition of fresh TMOF and NPG from one module to three modules (Table ), resulting in 1 order of magnitude elevation on Re and De that contribute to completing ketalization in a short time. Furthermore, the life-period of catalyst Amberlyst-15 resin was examined by operating the flow system continuously without interval and manual intervention.…”

Section: Resultsmentioning

confidence: 99%

Scalable and Integrated Four-step Continuous-Flow Synthesis of Ibuprofen Using a Zinc-Catalyzed 1,2-Aryl Migration Strategy

Li,

Liu,

Zhang

et al. 2024

ACS Sustainable Chem. Eng.

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Ibuprofen is an essential nonsteroidal anti-inflammatory drug (NSAID) which is still inaccessible to more than 100 million patients worldwide. Although three elegant continuous-flow approaches toward this NSAID have been developed, the major defect of requiring the use of a stoichiometric amount of highly toxic, corrosive, and expensive oxidizing reagents (such as di(acetoxy)phenyl iodide (PhI(OAc) 2 ) and iodine monochloride (ICl)) prevents their application in industrial manufacturing. Herein, a novel and catalytic synthesis of ibuprofen from commercially available isobutylbenzene is performed by a linear continuous-flow sequence involving four chemical transformations without conducting solvent exchanges or intermediate purifications. This newly developed proof-of-principle regime provided access to ibuprofen in a global yield of 80.6% with an average of 94.7% for each step in a total reaction time of 32.5 min, corresponding to a throughput of 15.22 g/h.

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Section: Resultsmentioning

confidence: 99%