Enhancing Memory for Relationship Actions by Transcranial Direct Current Stimulation of the Superior Temporal Sulcus

Hernández, Hipólito; Yagual, Sara Nila; García‐Marco, Enrique; Gámez, Elena; Beltrán, David; Díaz, Jorge Alberto Álvarez; Urrutia, Mabel

doi:10.3390/brainsci10080497

Cited by 8 publications

(7 citation statements)

References 63 publications

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“…This is similar to Wu’s findings ( Wu et al, 2020 ). The STG is considered a key structure involved in cognitive processing ( Riecke et al, 2017 ; Marrero et al, 2020 ). It plays an important role in emotional processing ( Peelen et al, 2010 ), decision-making ( Yang et al, 2016 ), and reward processing ( Vrieze et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Brain Functional Alterations in Prepubertal Boys With Autism Spectrum Disorders

Yue

Zhang

et al. 2022

Front. Hum. Neurosci.

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ObjectivesAbnormal brain function in ASD patients changes dynamically across developmental stages. However, no one has studied the brain function of prepubertal children with ASD. Prepuberty is an important stage for children’s socialization. This study aimed to investigate alterations in local spontaneous brain activity in prepubertal boys with ASD.Materials and MethodsMeasures of the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) acquired from resting-state functional magnetic resonance imaging (RS-fMRI) database, including 34 boys with ASD and 49 typically developing (TD) boys aged 7 to 10 years, were used to detect regional brain activity. Pearson correlation analyses were conducted on the relationship between abnormal ALFF and ReHo values and Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R) scores.ResultsIn the ASD group, we found decreased ALFF in the left inferior parietal lobule (IPL) and decreased ReHo in the left lingual gyrus (LG), left superior temporal gyrus (STG), left middle occipital gyrus (MOG), and right cuneus (p < 0.05, FDR correction). There were negative correlations between ReHo values in the left LG and left STG and the ADOS social affect score and a negative correlation between ReHo values in the left STG and the calibrated severity total ADOS score.ConclusionBrain regions with functional abnormalities, including the left IPL, left LG, left STG, left MOG, and right cuneus may be crucial in the neuropathology of prepubertal boys with ASD. Furthermore, ReHo abnormalities in the left LG and left STG were correlated with sociality. These results will supplement the study of neural mechanisms in ASD at different developmental stages, and be helpful in exploring the neural mechanisms of prepubertal boys with ASD.

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Section: Discussionmentioning

confidence: 99%

Brain Functional Alterations in Prepubertal Boys With Autism Spectrum Disorders

Yue

Zhang

et al. 2022

Front. Hum. Neurosci.

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“…The aim of our study has been to examine whether the advantage of approach content in the tDCS effect on sentence memorization [ 31 ] starts before, during sentence reading. Contrary to our expectations, reading speed of approach sentences did not benefit from anodal stimulation in rSTS.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding tDCS effects on the STS and relationship-actions processing, it has been found [ 31 ] found a greater improvement in discriminability of approach sentences in a memorization task after applying anodal tDCS on the rSTS, in comparison to either sham or cathodal stimulation [ 31 ]. However, the question whether the advantage of approach content could start before memorization, such as during sentence reading remains open.…”

Section: Introductionmentioning

confidence: 99%

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Personality Traits Modulate the Effect of tDCS on Reading Speed of Social Sentences

et al. 2021

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In this case, 62 university students participated in the study, in which a between-subjects design was adopted. Participants were also given the behavioral approach system (BAS) and behavioral inhibition system (BIS) scales. Participants had to read a list of 60 sentences with interpersonal and neutral content: 20 approach (“Pedro accepted Rosa in Whatsapp”), 20 avoidance (“Pedro Blocked Rosa in Whatsapp”) and 20 neutral (“Marta thought about the causes of the problem”). After reading them, they were subjected to 20 min of transcranial direct current stimulation (tDCS) in one of the two conditions: anodal (31) or sham (31). After tDCS, they had to read other list of 60 sentences matched in approach, avoidance and neutral contents with the former list. We found significant improvement in reading speed after anodal stimulation for social and neutral sentences. Regarding affective traits, we found that anodal stimulation benefitted reading speed in low-BIS and low-BAS participants and had no effect in either high BAS or high BIS participants. In addition, tDCS improvement in reading speed was significantly lower in avoidance sentences in low-BIS (avoidance) participants. We discuss these results at the light of previous research and highlight the importance of approach and avoidance traits as moderators of tDCS effects.

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“…The superior temporal gyrus is considered a key structure involved in cognitive processing [ 62 , 63 ]. Previous neuroimaging studies have explored structural alterations in the STG in patients with dementia or cognitive impairments.…”

Section: Discussionmentioning

confidence: 99%

Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study

Cai

Zhao

et al. 2021

Neural Plasticity

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Although many neuroimaging studies have reported structural and functional abnormalities in the brains of patients with cognitive impairments following stroke, little is known about the pattern of such brain reorganization in poststroke dementia (PSD). The present study was aimed at investigating alterations in spontaneous brain activity and gray matter volume (GMV) in PSD patients. We collected T1-weighted and resting-state functional magnetic resonance imaging data from 20 PSD patients, 24 poststroke nondementia (PSND) patients, and 21 well-matched normal controls (NCs). We compared the differences among the groups in GMV and the fractional amplitude of low-frequency fluctuations (fALFF). Then, we evaluated the relationship between these brain measures and cognitive assessments and explored the possible distinguisher for PSD by receiver operating characteristic (ROC) curve analysis. PSD patients showed smaller GMV in the right superior temporal gyrus and lower fALFF values in the right inferior frontal gyrus than both PSND patients and NCs, but such differences were not observed between PSND patients and NCs. Moreover, GMV in the left medial prefrontal cortex showed a significant positive correlation with the Mini-Cog assessment in PSD patients, and GMV in the left CPL displayed the highest area under the ROC curve among all the features for classifying PSD versus PSND patients. Our findings suggest that PSD patients show dementia-specific structural and functional alteration patterns, which may help elucidate the pathophysiological mechanisms underlying PSD.

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Enhancing Memory for Relationship Actions by Transcranial Direct Current Stimulation of the Superior Temporal Sulcus

Cited by 8 publications

References 63 publications

Brain Functional Alterations in Prepubertal Boys With Autism Spectrum Disorders

Brain Functional Alterations in Prepubertal Boys With Autism Spectrum Disorders

Personality Traits Modulate the Effect of tDCS on Reading Speed of Social Sentences

Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study

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