Enhancing Melanoma Treatment with Resveratrol

Osmond, Gregory W.; Augustine, Christina K.; Zipfel, Patricia A.; Padussis, James C.; Tyler, Douglas S.

doi:10.1016/j.jss.2010.07.033

Cited by 46 publications

(45 citation statements)

References 34 publications

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“…Resveratrol was shown to be selectively inhibitory of drug-resistant human melanoma cells DM738 and DM443 (at 50 µM) in comparison with normal dermal cells (5), and to inhibit highly invasive B16 F10 and B16 BL6 mouse melanoma cells (at 100 µM) (4). With regard to other cancer cells, resveratrol (at 50 µM) was demonstrated to have anti-estrogenic and anti-migration effects with metastatic human breast cells (14), and (at 1 µM) to promote apoptosis of human prostate cells via the MAPK pathway (21).…”

Section: Introductionmentioning

confidence: 99%

“…With regard to other cancer cells, resveratrol (at 50 µM) was demonstrated to have anti-estrogenic and anti-migration effects with metastatic human breast cells (14), and (at 1 µM) to promote apoptosis of human prostate cells via the MAPK pathway (21). Efforts to use resveratrol ( 1 ) in a mouse xenograft model were compromised by the difficulty in maintaining a high serum level of this drug over time due to its rapid clearance and metabolism (5). Consequently, analogues of resveratrol that have enhanced bioavailability are needed (22,23).…”

Section: Introductionmentioning

confidence: 99%

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Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells

et al. 2015

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Resveratrol (E-3,5,4’-trihydroxystilbene) is a polyphenol found in red wine that has been shown to have multiple anti-cancer properties. Although cis (Z) and trans (E) isomers of resveratrol occur in nature, the cis form is not biologically active. However, methylation at key positions of the cis form results in more potent anti-cancer properties. This study determined that synthetic cis-polymethoxystilbenes (methylated analogues of cis-resveratrol) inhibited cancer-related phenotypes of metastatic B16 F10 and non-metastatic B16 F1 mouse melanoma cells. In contrast with cis or trans-resveratrol and trans-polymethoxystilbene which were ineffective at 10 μM, cis-polymethoxystilbenes inhibited motility and proliferation of melanoma cells with low micromolar specificity (IC50 <10 μM). Inhibitory effects by cis-polymethoxystilbenes were significantly stronger with B16 F10 cells and were accompanied by decreased expression of β-tubulin and pleckstrin homology domain-interacting protein, a marker of metastatic B16 cells. Thus, cis-polymethoxystilbenes have potential as chemotherapeutic agents for metastatic melanoma.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells

et al. 2015

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“…Melanoma is the most lethal form of skin cancer and accounts for 75% of skin cancer-related deaths (Rizvi et al, 2006;Schneider et al, 2009;Osmond et al, 2012). At present, due to western medical treatments for cancer have side-effects, some attentions have shifted to discover new anti-cancer strategy, such as the use of traditional Chinese medicine, in the hope of producing anti-tumor effect without too many serious side-effects (Treasure et al, 2005;Cho et al, 2007;Li et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Once diagnosed, the first course of treatment for locally advanced and/or systemic disease is surgical resection, followed by chemotherapy, radiation therapy, and/or immunotherapy (Villa et al, 2004). Recently, therapy of melanoma has some breakthroughs (Hodi et al, 2010;Chapman et al, 2011); however, the treatment of advanced melanoma is highly challenging, in part because there are few effective therapeutic regimens (Balch et al, 2001;Bastiaannet et al, 2005;Osmond et al, 2012;Fang et al, 2013). Although those treatments are effective in many patients, not all patients will respond and many will have recurrence and/or progression of the melanoma.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Antitumor Efficacy with Combined Administration of Astragalus and Pterostilbene for Melanoma

Huang¹,

Zhang²,

Wang³

2014

Asian Pacific Journal of Cancer Prevention

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Astragalus, a commonly used traditional Chinese medicine, has exhibited antitumor actions in patients. In this study, in vitro and in vivo antitumor effects of astragalus and synergistic antitumor efficacy in combination with pterostilbene were investigated. Melanoma cells were treated with pterostilbene (Pt), graduated doses of astragalus injection (AI), or these in combination. Cell viability was measured using a MTT assay. Released nucleosomes and caspase activity were measured using enzyme-linked immunosorbent assay. Growth inhibition in vitro and in vivo was also assessed. Analysis of variance and t tests were used for statistical analysis. Significant reduction (p<0.05) in cellular proliferation were observed with AI and AI-Pt in a time-and concentration-dependent manner. Apoptosis and caspase-3/7 activity were significantly increased by AI and AI-Pt treatment (p<0.05). In vivo, AI inhibited melanoma tumor growth, with inhibition rates ranging from 36.5 to 62.3%, by inducing apoptosis via up-regulation Bax expression and the Bax/Bcl-2 ratio and down-regulating Bcl-2 expression. AI significantly inhibits the growth of melanoma in vitro and in vivo by inducing apoptosis. These data suggest that combined treatment of astragalus with pterostilbene enhances antitumor efficacy.

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“…Since resveratrol can cause DNA damage to squamous cell carcinoma in the head and neck area [202], causing p53-dependent apoptosis [203], and inhibiting accumulation of hypoxia-inducible factor-1α and vascular endothelial growth factor (VEGF) expression [204], resveratrol can be used as either a chemopreventive agent [205, 206] or a therapeutic one, improving cytotoxic irradiation-based therapy, by decreasing cyclin B, cyclin D, CDK2, CDK4, and the anti-apoptotic molecule Fas-associated protein with death domain-like IL-1β-converting enzyme-inhibitory protein (FLIP), Bcl-2, and SVV [178, 207–209]. Resveratrol may also improve the cytotoxicity of 5-fluorouracil [210, 211] (Table 1; Fig.…”

Section: Resveratrolmentioning

confidence: 99%

Use of Polyphenolic Compounds in Dermatologic Oncology

2016

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Polyphenols are a widely used class of compounds in dermatology. While phenol itself, the most basic member of the phenol family, is chemically synthesized, most polyphenolic compounds are found in plants and form part of their defense mechanism against decomposition. Polyphenolic compounds, which include phenolic acids, flavonoids, stilbenes, and lignans, play an integral role in preventing the attack on plants by bacteria and fungi, as well as serving as cross-links in plant polymers. There is also mounting evidence that polyphenolic compounds play an important role in human health as well. One of the most important benefits, which puts them in the spotlight of current studies, is their antitumor profile. Some of these polyphenolic compounds have already presented promising results in either in vitro or in vivo studies for non-melanoma skin cancer and melanoma. These compounds act on several biomolecular pathways including cell division cycle arrest, autophagy, and apoptosis. Indeed, such natural compounds may be of potential for both preventive and therapeutic fields of cancer. This review evaluates the existing scientific literature in order to provide support for new research opportunities using polyphenolic compounds in oncodermatology.

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Enhancing Melanoma Treatment with Resveratrol

Cited by 46 publications

References 34 publications

Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells

Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells

Enhanced Antitumor Efficacy with Combined Administration of Astragalus and Pterostilbene for Melanoma

Use of Polyphenolic Compounds in Dermatologic Oncology

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