Enhancing magnetic hyperthermia in ferrite nanoparticles through shape anisotropy and surface hybridization

Abstract

Magnetic hyperthermia has been studied for the past two decades in cancer treatments as the local heat generated by magnetic nanoparticles under applied alternating magnetic fields is sufficient to kill cancer cells. More recently, it has been explored for controlling biological signaling through heat-sensitive transmembrane channels. It is of great interest to produce magnetic nanoparticles with high heat transducing efficiency to minimize potential off-target heating effects. Here, we describe shape anisotropy and particle hybridization as possible routes to augment magnetic hyperthermia in ferrite nanoparticles. Zinc substituted magnetite core and core-shell cubic nanoparticles with different sizes were synthetized. It was found that nanoparticles shape and composition are altered from cubic to flower-like, and to a more franklinite rich phase as size increased. Hybridization with a cobalt shell allowed to enhance nanoparticle magnetic coercivity and specific power loss. The optimized core-shell nanoparticles were tested to induce cellular activity in hippocampal neurons.

Highly efficient green up-conversion emission from fluoroindate glass nanoparticles functionalized with a biocompatible polymer

“…The second step was adapted from our previous work, 41 which consists in dispersing 2.5 g of PEG in 30 mL of diethylene glycol (DEG) at 100 °C under reflux and magnetic stirring for 30 min, then the particles, previously dispersed in hexane, were injected into the solution. Once injected, the solution was heated to 200 °C and maintained for 3 hours, and then cooled to room temperature.…”

Morphology‐controlled precipitation/remodeling of plate and rod‐shaped hydroxyapatite nanoparticles

“…22 That is why precipitation is the most investigated process, also in terms of affecting the particle's size and morphology by varying the synthesis conditions. 23 The control of the morphology of the produced nanoparticles concerns ceramic particles, such as calcium phosphates or calcium carbonate, 24 metallic, 25 polymer, 26 and other particles. Regardless of the process of obtaining particles and their size, control of the morphology and size of individual particles in processes such as crystallization and precipitation remains challenging as it is an instantaneous process.…”

Decoupling gaseous hydrogen production from liquid water using a magnetic‐photo‐thermal coupling reactor

“…The magnetic semiconductor could be heated under alternating magnetic field (AMF) via hysteresis effect or eddy‐current effect, and then the generated heat directly enhances the reaction rate 11 . For example, Jiménez et al synthesized cubic magnetic nanoparticles composed of ZnFe 2 O 4 core and CoFe 2 O 4 shell to enhance heat‐sensitive ion channels, which could be used as nanotransducers under AMF condition 12 . Lam et al discovered that the iron oxide‐loaded polymer scaffolds could kill the ovarian cancer cells through the hysteresis effect under AMF condition 13 .…”

“…11 For example, Jiménez et al synthesized cubic magnetic nanoparticles composed of ZnFe 2 O 4 core and CoFe 2 O 4 shell to enhance heat-sensitive ion channels, which could be used as nanotransducers under AMF condition. 12 Lam et al discovered that the iron oxide-loaded polymer scaffolds could kill the ovarian cancer cells through the hysteresis effect under AMF condition. 13 Despite these successful demonstrations, the effect of alternating magnetic field on heating and charge separation in solar photocatalytic hydrogen production from water has been rarely reported.…”