The printing quality delivered by a Drop-on-Demand (DoD) inkjet printhead is severely affected by the residual oscillations in an ink channel and the cross-talk between neighboring ink channels. For a single ink channel, our earlier contribution shows that the actuation pulse can be designed, using a physical model, to effectively damp the residual oscillations. It is not always possible to obtain a good physical model for a single ink channel. A physical model for a multi-input multioutput (MIMO) inkjet printhead is made even more sophisticated by the presence of the cross-talk effect. This paper proposes a system identification-based approach to build a MIMO model for an inkjet printhead. Additionally, the identified MIMO model is used to design new actuation pulses to effectively minimize the residual oscillations and the cross-talk. Using simulation and experimental results, we demonstrate the efficacy of the proposed method. ‡ This research has been carried out as part of the Octopus project with Océ Technologies B.V. under the responsibility of the Embedded Systems Institute. This project is partially supported by the Netherlands Ministry of Economic Affairs under the Bsik program P90600.