Enhancing effects of radiopaque agent BaSO4 on mechanical and biocompatibility properties of injectable calcium phosphate composite cement

Liu, Huiling; Zhang, Zhenyi; Gao, Chunxia; Bai, Yanjie; Liu, Bin; Wang, Weihua; Ma, Yanxia; Saijilafu,; Yang, Huilin; Li, Yadong; Chan, Adrian; Yang, Lei

doi:10.1016/j.msec.2020.110904

Cited by 23 publications

(16 citation statements)

References 35 publications

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“…CPC and CPB pastes were prepared as previously reported. 31 CPC powder was prepared by mixing α-tricalcium phosphate (α-TCP) and dicalcium phosphate dehydrate (DCPD) at the ratio of 9:1 (wt/wt) and ball-milled as previously reported. 15 Then the CPC powder (2 g) was mixed with 1.4 ml of Na 2 HPO 4 (0.25 mol/L) solution to create a CPC paste.…”

Section: Preparation Of Cpc and Starch-modified Bone Cement (Cpb) Pastesmentioning

confidence: 99%

“…15,30 According to our previous studies, starch-modified CPC had excellent biocompatibility both in vitro and in vivo. 31 Native starch naturally exists in granular form and is insoluble in cold water at ambient temperature. In previous studies, starch was either solubilized in boiling water or pregelatinized before mixing with the CPC powder.…”

Section: Introductionmentioning

confidence: 99%

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Calcium phosphate‐based composite cement: Impact of starch type and starch pregelatinization on its physicochemical properties and performance in the vertebral fracture surgical models in vitro

Tian

Liu

et al. 2021

J Biomed Mater Res

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Calcium phosphate cement (CPC) modified with native and pregelatinized normal corn and waxy maize starches was studied. Effects of starch pregelatinization and starch type on the physicochemical properties of CPC were investigated. CPC modified with pregelatinized normal corn starch (CPB-PNC) or pregelatinized waxy maize starch (CPB-PW) was evaluated by two vertebral fracture surgical models in vitro.Both granular and pregelatinized starches significantly improved the setting times and injectability of CPC, but only the pregelatinized starches improved the anticollapsibility and compressive strength of CPC significantly. CPB-PW, whose microstructure was compact and uniform, showed the best physicochemical properties. Addition of starch did not inhibit the hydro-reaction of CPC. Unmodified CPC had very poor dispersibility and could not apply in the tests of the surgical models.Pregelatinized starch especially waxy maize starch improved the dispersibility of CPC and showed good dispersion area, volume, improved pull-out force and maximum torque in the Sawbones sponge model. Similarly, in the minimally invasive kyphoplasty model, CPB-PNC and CPB-PW could disperse in the osteoporotic sheep vertebrae and improve the compressive strength of the sheep vertebral body. In conclusion, starch pregelatinization and starch botanical source affect the physicochemical properties of CPC significantly. Bone cements modified by different starches also Abbreviations: CICPS, cement-injectable cannulated pedicle screw; CPB, CPC and the radiopaque agent BaSO4; CPB-NC, CPB modified with native normal corn starch; CPB-PNC, CPB modified with pregelatinized normal corn starch; CPB-PW, CPB modified with pregelatinized waxy maize starch; CPB-W, CPB modified with native waxy maize starch; CPC, calcium phosphate cement; DCPD, dicalcium phosphate dihydrate (CaHPO 4 •2H 2 O); OP, osteoporosis; OVCF, osteoporotic vertebral compression fracture; PMMA, polymethyl methacrylate; RVA, rapid visco analyzer; α-TCP, alpha-tricalcium phosphate (α-Ca 3 (PO 4 ) 2 ).Yixing Tian and Huiling Liu contributed equally to this study.

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Section: Preparation Of Cpc and Starch-modified Bone Cement (Cpb) Pastesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Calcium phosphate‐based composite cement: Impact of starch type and starch pregelatinization on its physicochemical properties and performance in the vertebral fracture surgical models in vitro

Tian

Liu

et al. 2021

J Biomed Mater Res

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“…Commonly, bone repair scaffolds are required to possess high radiopacity for noninvasively tracking and imaging the filling effect in clinical operations, in vivo degradation, and new bone growth by X-ray-based techniques, such as fluoroscopy, computer tomography, and radiography [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. However, the intrinsic radiopacity of bone repair scaffolds is usually insufficient, and it is difficult to distinguish them from natural bone tissues.…”

Section: Introductionmentioning

confidence: 99%

“…However, the intrinsic radiopacity of bone repair scaffolds is usually insufficient, and it is difficult to distinguish them from natural bone tissues. For enhancing their radiopacity, X-ray contrast agents such as Ba-based [ 22 , 23 ], Zr-based [ 24 , 25 , 26 ], Bi-based [ 27 , 28 , 29 ], and Sr-based [ 30 , 31 , 32 ] compounds are added into them to construct the composite scaffolds. Although BaSO 4 and ZrO 2 are widely used in poly (methyl methacrylate) (PMMA) bone cements as the radiopacifier, there are potential physical, mechanical, and biological risks if the particles are released from the scaffolds as they are unabsorbable in the physiological environment [ 22 , 24 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid Fabrication of MgNH4PO4·H2O/SrHPO4 Porous Composite Scaffolds with Improved Radiopacity via 3D Printing Process

Cao

Wang

et al. 2021

Biomedicines

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Although bone repair scaffolds are required to possess high radiopacity to be distinguished from natural bone tissues in clinical applications, the intrinsic radiopacity of them is usually insufficient. For improving the radiopacity, combining X-ray contrast agents with bone repair scaffolds is an effective method. In the present research, MgNH4PO4·H2O/SrHPO4 3D porous composite scaffolds with improved radiopacity were fabricated via the 3D printing technique. Here, SrHPO4 was firstly used as a radiopaque agent to improve the radiopacity of magnesium phosphate scaffolds. X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS) were used to characterize the phases, morphologies, and element compositions of the 3D porous composite scaffolds. The radiography image showed that greater SrHPO4 contents corresponded to higher radiopacity. When the SrHPO4 content reached 9.34%, the radiopacity of the composite scaffolds was equal to that of a 6.8 mm Al ladder. The porosity and in vitro degradation of the porous composite scaffolds were studied in detail. The results show that magnesium phosphate scaffolds with various Sr contents could sustainably degrade and release the Mg, Sr, and P elements during the experiment period of 28 days. In addition, the cytotoxicity on MC3T3-E1 osteoblast precursor cells was evaluated, and the results show that the porous composite scaffolds with a SrHPO4 content of 9.34% possessed superior cytocompatibility compared to that of the pure MgNH4PO4·H2O scaffolds when the extract concentration was 0.1 g/mL. Cell adhesion experiments showed that all of the scaffolds could support MC3T3-E1 cellular attachment well. This research indicates that MgNH4PO4·H2O/SrHPO4 porous composite scaffolds have potential applications in the bone repair fields.

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“…Many efforts have been devoted to increasing the viscosity of the liquid phase of CPC by adding natural biopolymers, such as sodium polyacrylate (PAAS) [ 10 ], gelatin microspheres [ 11 ], guar gum [ 12 ], locust bean gum [ 13 ] and chondroitin sulfate [ 14 ] (see Table 1 ). However, the increase in the anti-washout property is always accompanied by a decline of compressive strength and an extension of setting time [ 15 ]. It has been widely reported that the initial mechanical property of CPC is also a critical issue that needs to be addressed, which decides whether the CPC could be strong enough to support bone regeneration [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Setting Characteristics and High Compressive Strength of an Anti-washout, Injectable Calcium Phosphate Cement Combined with Thermosensitive Hydrogel

Xie

Liu²,

Cai

et al. 2020

Materials

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In this work, a thermosensitive poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) hydrogel was introduced into calcium phosphate cement (CPC) to enhance the anti-washout property of CPC. The effects of the hydrogel on the setting time, injectability, anti-washout property and compressive strength of CPC were thoroughly investigated. The results showed that the hydrogel significantly increased the injectability and anti-washout property of CPC, meanwhile maintained the setting time with an acceptable range. Moreover, the hydrogel improved the initial compressive strength of CPC. The composite cement with 20% v/v hydrogel in the liquid phase showed fine crystals of hydration product, a more compact microstructure and lower porosity compared with control CPC. The analysis of X-ray diffraction (XRD), infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) indicated that suitable volume ratio of hydrogel (20% v/v) in the setting liquid of CPC could promote the formation of hydroxyapatite in the early hydration period. The degradation behavior of the cement was characterized by immersion tests in simulated body fluid. The hydrogel had no adverse effect on the degradation rate of CPC over the immersion period of 23 days. This study indicated that incorporating PLGA-PEG-PLGA hydrogel could be a promising strategy to reinforce the handing properties and initial compressive strength of calcium phosphate cement.

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Enhancing effects of radiopaque agent BaSO4 on mechanical and biocompatibility properties of injectable calcium phosphate composite cement

Cited by 23 publications

References 35 publications

Calcium phosphate‐based composite cement: Impact of starch type and starch pregelatinization on its physicochemical properties and performance in the vertebral fracture surgical models in vitro

Calcium phosphate‐based composite cement: Impact of starch type and starch pregelatinization on its physicochemical properties and performance in the vertebral fracture surgical models in vitro

Rapid Fabrication of MgNH4PO4·H2O/SrHPO4 Porous Composite Scaffolds with Improved Radiopacity via 3D Printing Process

Setting Characteristics and High Compressive Strength of an Anti-washout, Injectable Calcium Phosphate Cement Combined with Thermosensitive Hydrogel

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