Enhancing Effect of Suspended Particulate Matter on the IgE Antibody Production in Mice

Takafuji, Shigeru; Suzuki, Shuji; Koizumi, Kazuhiro; Tadokoro, Kenji; Ohashi, Haruo; Muranaka, M; Miyamoto, Tomofumi

doi:10.1159/000234990

Cited by 71 publications

(34 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Guinea pigs exposed to sulfur dioxide can develop allergic respiratory disorders (31) and increased antibody responses to allergens (32). Intranasal exposure of mice to DEP increases IgE antibody but not the IgG response to ovalbumin (8,9). Similarly, rats and human exposed to tobacco smoke, which contains PAH such as benzo(a)pyrene also found in DEP, have increased serum IgE (33).…”

Section: Discussionmentioning

confidence: 99%

“…Simultaneous administration of DEP increased IgE production to bystander antigens such as ovalbumin and Japanese cedar pollen when injected intraperitoneally (7,9). In addition, intranasal administration of DEP caused an increase in the IgE but not the IgG response (8,9). Previous reports have demonstrated that some PAH can have direct effects on lymphocytes, both T cells (10) and on B cells (11).…”

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms.

Díaz-Sánchez¹,

Dotson²,

Takenaka³

et al. 1994

J. Clin. Invest.

353

204

View full text Add to dashboard Cite

Diesel exhaust particles (DEP) have been implicated in the increased incidence of allergic airway disorders. We investigated the effects of DEP on localized immunoglobulin production by performing nasal challenges with varying doses of DEP and analyzing the local immune response in nasal lavages obtained before and after. A significant rise in nasal IgE but not IgG, IgA, IgM, or albumin was observed in subjects 4 d after challenge with 0.30 mg DEP, equivalent to exposure on an average Los Angeles day. Direct evidence for DEP-enhanced local production of IgE was that challenge increased the number of IgE-secreting cells in lavage fluid from < 1 in 2,000,000 to > 1 in 100,000 but did not alter the number of IgA-secreting cells. There was a concomitant increase in epsilon mRNA production in the lavage cells. Additionally, DEP altered the relative amounts of five different epsilon mRNAs generated by alternative splicing, mRNAs that code for different IgE proteins. These results show that DEP exposure in vivo causes both quantitative and qualitative changes in local IgE production. The implication is that natural exposure to DEP may result in increased expression of respiratory allergic disease. (J. Clin.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms.

Díaz-Sánchez¹,

Dotson²,

Takenaka³

et al. 1994

J. Clin. Invest.

353

204

View full text Add to dashboard Cite

show abstract

“…Furthermore, daily inhalation of DEPs may enhance the allergen response, possibly by increased local expression of proin¯amma-tory cytokines such as IL-5 and GM-CSF [67]. In one study, increased IgE production was also seen in mice after intranasal administration of suspended particulate matter (SPM) together with OA at 3-week intervals for a period of 21 weeks [68].…”

Section: In Vivo Studiesmentioning

confidence: 99%

Health effects of diesel exhaust emissions

et al. 2001

View full text Add to dashboard Cite

Epidemiological studies have demonstrated an association between different levels of air pollution and various health outcomes including mortality, exacerbation of asthma, chronic bronchitis, respiratory tract infections, ischaemic heart disease and stroke. Of the motor vehicle generated air pollutants, diesel exhaust particles account for a highly significant percentage of the particles emitted in many towns and cities. This review is therefore focused on the health effects of diesel exhaust, and especially the particular matter components.Acute effects of diesel exhaust exposure include irritation of the nose and eyes, lung function changes, respiratory changes, headache, fatigue and nausea. Chronic exposures are associated with cough, sputum production and lung function decrements. In addition to symptoms, exposure studies in healthy humans have documented a number of profound inflammatory changes in the airways, notably, before changes in pulmonary function can be detected. It is likely that such effects may be even more detrimental in asthmatics and other subjects with compromised pulmonary function.There are also observations supporting the hypothesis that diesel exhaust is one important factor contributing to the allergy pandemic. For example, in many experimental systems, diesel exhaust particles can be shown to act as adjuvants to allergen and hence increase the sensitization response.Much of the research on adverse effects of diesel exhaust, bothin vivoandin vitro, has however been conducted in animals. Questions remain concerning the relevance of exposure levels and whether findings in such models can be extrapolated into humans. It is therefore imperative to further assess acute and chronic effects of diesel exhaust in mechanistic studies with careful consideration of exposure levels. Whenever possible and ethically justified, studies should be carried out in humans.

show abstract

“…Intraperitoneal injection of DEPs has been reported to increase the IgE response to ovalbumin and to Japanese cedar pollen (52,53). DEPs inoculated by the intranasal route act as an adjuvant activity for IgE production in mice (54).…”

Section: Mechanisms Of Diesel Exhaust-inducedmentioning

confidence: 99%

“…Diesel exhaust particles have been shown to adsorb several antigens, such as ovalbumin and the grass pollen major allergen Lolp-1, onto their surface (52,64) and, therefore, act as potential carriers of allergens, increasing their deposition in the respiratory tract. Thus, DEPs not only enhance the antigenicity of the allergen (65) but also increase the allergen dose reaching the lungs.…”

Section: Mechanisms Of Diesel Exhaust-inducedmentioning

confidence: 99%

Particulate Air Pollution from Motor Vehicles: A Putative Proallergic Hazard?

Polosa¹,

Salvi

1999

Canadian Respiratory Journal

View full text Add to dashboard Cite

Air pollution generated from motor vehicle exhaust has become a major cause for scientific and public concern worldwide over recent years. The rapid and marked increase in the motor vehicle traffic and its associated emissions in urban areas have paralleled a sharp increase in the prevalence of allergic diseases such as asthma and rhinitis. Epidemiological studies have demonstrated a strong association between people living in close proximity to roads with high traffic density and increased allergic symptoms, reduced lung function and increased sensitization to common aeroallergens. Several laboratory-based studies have demonstrated that pollutants emitted from motor vehicles can induce allergic inflammation and increase airway hyperresponsiveness, which may provide an underlying mechanism for the increasing prevalence of allergic diseases. Although the detrimental effects of air pollution on human health have been brought to public attention, it appears that less attention has been given to the potential role of road traffic fumes in the induction of the allergic state. Legislators should consider pollutants emitted from motor vehicle exhausts as a potential pro-allergic hazard, before making important changes in environmental policy.

show abstract

Enhancing Effect of Suspended Particulate Matter on the IgE Antibody Production in Mice

Cited by 71 publications

References 7 publications

Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms.

Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms.

Health effects of diesel exhaust emissions

Particulate Air Pollution from Motor Vehicles: A Putative Proallergic Hazard?

Contact Info

Product

Resources

About