Enhancing effect of surfactants on fexofenadine·HCl transport across the human nasal epithelial cell monolayer

Lin, Hongxia; Gebhardt, M.; Bian, Shengjie; Kwon, Kyoung Ae; Shim, Chang‐Koo; Chung, Suk-Jae; Kim, Dae‐Duk

doi:10.1016/j.ijpharm.2006.08.043

Cited by 86 publications

(47 citation statements)

References 26 publications

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“…18,19) In addition, TEER measurements have been reported to indicate the permeablity of cell monolayers and their barrier properties. 20,21) Therefore, we used TEER values to monitor the damage induced by Cap in Caco-2 cells.…”

Section: Discussionmentioning

confidence: 99%

Effects of Capsaicin on Cellular Damage and Monolayer Permeability in Human Intestinal Caco-2 Cells

Tsukura

Mori

Hirotani

et al. 2007

Biological & Pharmaceutical Bulletin

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Recent studies suggest that capsaicin (Cap), a major constituent of hot pepper, may affect the function and permeability of the intestinal mucosa in vitro. However, the relationships between the dose of Cap and the barrier and/or transporter functions on intestinal epithelial cells are unknown. The aim of this study was to investigate whether Cap initiates cellular injury and alter epithelial permeability in Caco-2 cells. Cellular toxicity, as measured using a lactate dehydrogenase release assay, was not observed at high concentrations of Cap (up to 300 m mM).

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Section: Discussionmentioning

confidence: 99%

Effects of Capsaicin on Cellular Damage and Monolayer Permeability in Human Intestinal Caco-2 Cells

Tsukura

Mori

Hirotani

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Tissue sections were observed under Olympus CKX41 optical microscope (Olympus Optical Co. Ltd., Tokyo, Japan). 16,22 The photographs were taken with an Olympus-SC 35 camera ( Figure 5). …”

Section: Histological Evaluation Of Nasal Mucosamentioning

confidence: 99%

Experimentation on Hibiscus rosa Flower Mucilage as a Potential Nasal Mucoadhesive its Characterization as an In-situ Gel for some Anxiolytics

Roy¹,

Haldar²,

Chhetri³

2016

JYP

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Objective: The objective of the present study was to prepare mucoadhesive in situ nasal gels with mucilage isolated from hibiscus flower (Hibiscus rosa sinensis, family: malveceae) containing alprazolam. Methods-Nasal gels of alprazolam were prepared using three different concentration (0.5%, 1% and 1.5% w/v) of H Rosa mucilage (HRM) and synthetic polymers (Hydroxy propyl methyl cellulose and carbopol 934). In situ gels were prepared with mixture of pluronic F127 and mucoadhesive agent. Result: Evaluation of HRM showed that it was as safe as the synthetic polymer for nasal administration. Evaluation of the prepared gel was carried out, including determination of viscosity, texture profile analysis and mucoadhesive strength. In vitro drug permeation study was conducted with the gels prepared with and without permeation enhancer (0.5% w/v sodium taurocholate) using excised goat nasal mucosa. For the determination of any further histological changes, before and after in vitro permeation study of the gels, with and without the permeation enhancer was also conducted. In vivo experiment conducted in rabbits further confirms that in situ nasal gel prepared with HRM provided better bioavailability of alprazolam than the gels prepared from synthetic mucoadhesive polymer. Conclusion: It was observed that the nasal gel containing 0.5% HRM and 0.5% sodium taurocholate exhibited appropriate rheological, mechanical and mucoadhesive properties and showed better drug release profile. More over this formulation produced no damage to the nasal mucosa used for the permeation study, and absolute bioavailability was also higher compare to gels prepared from synthetic polymers.

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“…Use of nanoparticles, mucoadhesive agents, absorption enhancers, surfactants, lipid emulsions, vasoconstrictors and efflux transporter inhibitors are some of the potential approaches to reduce the clearance and enhance the residence time [29][30][31][32][33][34][35][36][37].…”

Section: Nanoparticular Delivery Systemmentioning

confidence: 99%

Recent Updates in the Formulation Strategies to Enhance the Bioavailability of Drugs Administered via Intranasal Route

Dudhipala¹,

Narala²,

Bomma³

2016

J Bioequiv Availab

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Enhancing effect of surfactants on fexofenadine·HCl transport across the human nasal epithelial cell monolayer

Cited by 86 publications

References 26 publications

Effects of Capsaicin on Cellular Damage and Monolayer Permeability in Human Intestinal Caco-2 Cells

Effects of Capsaicin on Cellular Damage and Monolayer Permeability in Human Intestinal Caco-2 Cells

Experimentation on Hibiscus rosa Flower Mucilage as a Potential Nasal Mucoadhesive its Characterization as an In-situ Gel for some Anxiolytics

Recent Updates in the Formulation Strategies to Enhance the Bioavailability of Drugs Administered via Intranasal Route

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