2015
DOI: 10.1016/j.jff.2015.05.013
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Enhancing effect of natural borneol on the cellular uptake of demethoxycurcumin and their combined induction of G2/M arrest in HepG2 cells via ROS generation

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Cited by 10 publications
(5 citation statements)
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References 49 publications
(38 reference statements)
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“…The SPRi-MS results reveal that ABCB5 and MDR3 are captured by NB, which further supports this hypothesis. Previously, we found that NB could synergize with selenocystine, curcumin, and bisdemethoxycurcumin to induce significant anticancer activities 18 - 20 . However, the exact mechanisms and the therapeutic target of NB remained elusive.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The SPRi-MS results reveal that ABCB5 and MDR3 are captured by NB, which further supports this hypothesis. Previously, we found that NB could synergize with selenocystine, curcumin, and bisdemethoxycurcumin to induce significant anticancer activities 18 - 20 . However, the exact mechanisms and the therapeutic target of NB remained elusive.…”
Section: Discussionmentioning
confidence: 99%
“…Accumulating evidence shows that NB can promote the transdermal and mucosal absorption of drugs 16 , 17 . Recently, NB has been shown to enhance the anti-tumor effects of selenocysteine 18 , curcumin 19 , didemethoxycurcumin 20 , cisplatin 21 , and paclitaxel 6 . Although these studies suggest the potential application of NB in cancer prevention, it is not clear whether NB can be used to improve the therapeutic efficiency of chemotherapy in lung cancer treatment.…”
Section: Introductionmentioning
confidence: 99%
“…In most cancer cells, the Akt signaling pathway also plays an important role in the G2/M phase and in apoptosis and survival [71]. Chen et al (2015) found that flavin compounds can induce G2/M phase arrest in cells by regulating the Akt pathway [72]. In addition, inhibition of Akt activation can also inhibit cancer cell migration by upregulating E-calmodulin, β-linked protein and downregulating the mesenchymal cell waveform protein [73,74].…”
Section: Screening By Molecular Docking Simulationmentioning
confidence: 99%
“…Nowadays, accumulating studies have shown that borneol can promote the transdermal and mucosal absorption of drugs. Recently, some studies disclosed that borneol can enhance the anti-tumor effects of selenocysteine [17], curcumin [18], didemethoxycurcumin [19], cisplatin [20] and paclitaxel [9]. Although these studies have suggested the 4 potential application prospect of borneol in cancer prevention, it is not clear whether borneol can be used to improve the therapeutic efficiency of chemotherapy in lung cancer treatment, and the candidate target of borneol in chemotherapy is remain to be authenticated.…”
Section: Introductionmentioning
confidence: 99%