2007
DOI: 10.1590/s1516-93322007000100014
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Enhancing effect of modified beta-cyclodextrins on in vitro skin permeation of estradiol

Abstract: Estradiol, the most important hormone in females, was complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD) and randomly methylated β-cyclodextrin (RM-β-CD

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Cited by 8 publications
(12 citation statements)
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References 27 publications
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“…The emulsion containing the HPβCD-entrapped extract was stored in a well-closed glass container at an accelerated temperature, 45.0 ± 2.0°C for www.scienceasia.org 90 days 29 . The physical characteristics including droplet size, viscosity, and pH at before and after stability test under storage condition were determined.…”
Section: Stability Studymentioning
confidence: 99%
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“…The emulsion containing the HPβCD-entrapped extract was stored in a well-closed glass container at an accelerated temperature, 45.0 ± 2.0°C for www.scienceasia.org 90 days 29 . The physical characteristics including droplet size, viscosity, and pH at before and after stability test under storage condition were determined.…”
Section: Stability Studymentioning
confidence: 99%
“…The skin tissue was mounted on the receptor compartment with the epidermal side facing upward into the donor compartment. The temperature of the receptor medium was set at 37°C, and the skin temperature was controlled at 32 ± 1°C as described previously 29,30 . One hundred milligrams of the emulsion containing the HPβCD-entrapped extract or the unentrapped extract were evenly spread on the surface of stratum corneum (st. corneum), outermost layer of epidermis.…”
Section: In Vitro Permeation Studymentioning
confidence: 99%
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“…Hampered aqueous solubility of native β-CD had given advantage for chemical modification by substitution with alkyl groups like methyl, hydroxypropyl and sulfobutyl ether resulting in enormous amplification in solubility with good safety profile [8]. Modified β-CD have gained wider applications in delivering the drugs (BCS class II and IV) via different routes of administration due to their increased solubilizing effect resulting in stable inclusion complexes and improved permeation across biological membranes [9,10].…”
Section: Introductionmentioning
confidence: 99%