Enhancing effect of methamphetamine on ambulatory activity produced by repeated administration in mice

Hirabayashi, Makizo; Alam, Mohammed Rabiul

doi:10.1016/0091-3057(81)90056-3

Cited by 130 publications

(47 citation statements)

References 15 publications

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“…In addition, there was almost no development of enhancement in animals that had been pre treated repeatedly with the drugs and confined in a narrow environment (glass jar of 5.5 cm in diameter and 15 cm height) (2)(3)(4)(5). These findings suggest that such a sensitization phe nomenon is strongly affected by the dimen sions of the activity cage in which the animal move about under the drug effect.…”

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confidence: 68%

“…We have demonstrated previously that re peated administration of psychotropic drugs, such as d-amphetamine (1), methamphetamine (2), morphine (3), methylphenidate (4), ephedrine (5), apomorphine (6) and bromo criptine (7), to mice in adequate doses and at adequate intervals produced marked and pro gressive enhancement of the ambulation-in creasing effects (AIE) of the drugs when ex amined in a tilting-type round activity cage of 20 cm in diameter. This phenomenon, so called sensitization or reverse tolerance, has been widely supported by many investigators (8)(9)(10)(11).…”

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confidence: 99%

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Differential Sensitization to Ambulation-Increasing Effect of Methamphetamine after Repeated Administration to Mice in Activity Cages of Different Sizes

Hirabayasi

Saito

Tadokoro

1991

Japanese Journal of Pharmacology

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ABSTRACT-We have demonstrated that repeated administration of methampheta mine (MAP) 1 2 mg/kg, s. c. in a tilting-type round activity cage with a diameter of 20 cm (20 cm-cage) at 1 7 day intervals produces progressive enhancement of the ambulation-increasing effect (AIE), showing sensitization (reverse tolerance) in mice. However, almost no sensitization was observed when mice had been pretreated with the same doses of MAP but confined in a narrow environment repeatedly. In this ex periment, changes in the sensitization were investigated in mice after repeated pre treatments with MAP at 2 mg/kg at 3 4 day interval for 4 times in activity cages of 5 different sizes (5, 10, 15, 30 and 40 cm in diameter) in comparison with that of in the 20 cm-cage. AIE obtained after MAP in the 5 and 10-cm cages was not enhanced, whereas AIE was significantly enhanced in the cages of more than 15 cm in diameter. There was no significant difference in the enhanced AIE among the 4 groups that 're ceived the same pretreatment repeatedly in the cages of 15, 20, 30 and 40 cm in diam eter. The present results suggest that in accordance with the all-or-none law, develop ment of the sensitization is affected by the size of the activity cage in which the ani mals have repeatedly experienced the acute drug effect.

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confidence: 68%

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confidence: 99%

Differential Sensitization to Ambulation-Increasing Effect of Methamphetamine after Repeated Administration to Mice in Activity Cages of Different Sizes

Hirabayasi

Saito

Tadokoro

1991

Japanese Journal of Pharmacology

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“…It is important to emphasize that for all groups the test cages were identical, because the physical characteristics of the test environment can have a large effect on both the acute response to a drug (Beck et al 1986;Ellinwood and Kilbey 1975), and on the induction of sensitization (Hirabayashi and Alam 1981).…”

Section: Groupsmentioning

confidence: 99%

The Ability of Environmental Context to Facilitate Psychomotor Sensitization to Amphetamine Can Be Dissociated from Its Effect on Acute Drug Responsiveness and on Conditioned Responding

Crombag

Badiani

Chan

et al. 2001

Neuropsychopharmacology

112

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Doses of amphetamine or cocaine that fail to induce psychomotor sensitization when given to a rat in its home NO . 6 Psychomotor Sensitization to Amphetamine 681 increasing attention because the neural changes underlying sensitization to drugs of abuse may contribute to addiction (Lett 1989;Piazza et al. 1989;Robinson and Berridge 1993). In studying the conditions that facilitate or retard sensitization we have found that the context in which drugs are administered has a large effect on their ability to induce psychomotor sensitization (Badiani et al. 1995a(Badiani et al. , 1995bRobinson et al. 1998, for review). For example, doses of amphetamine, cocaine, or morphine that fail to induce psychomotor sensitization when given in the home cage, induce robust sensitization when given in a distinct and relatively novel environment (Badiani et al. 2000b;Browman et al. 1998aBrowman et al. , 1998bCrombag et al. 1996). The mechanisms responsible for the facilitation of sensitization by a distinct environment are not known, but it is tempting to relate them to associative learning processes (Badiani et al. 1995a(Badiani et al. , 1995b. Indeed, it has been suggested that sensitization may be the result of a progressive increase in the ability of treatment-related stimuli to elicit a conditioned response (CR), which adds to the unconditioned drug response (UR) (Hinson and Poulos 1981;Pert et al. 1990;Tilson and Rech 1973). If this hypothesis is correct, manipulations that degrade the ability of contextual stimuli to acquire conditioned stimulus (CS) properties should attenuate the facilitation of sensitization that occurs when drugs are administered in a distinct environment. Increasing the interval between presentation of the would-be CS and the unconditioned stimulus (US) is known to impair conditioning (Kimble 1947;Pickens and Crowder 1967). Therefore, in the present experiment we studied the effect of increasing the CS-US interval on the development of sensitization produced by amphetamine, by habituating rats to the test environment prior to drug administration. The psychomotor stimulant effects of repeated intravenous (i.v.) injections of amphetamine were assessed by quantifying rotational behavior in rats with a unilateral 6-OHDA lesion. Injections were given (1) in the absence of any environmental stimuli predictive of drug administration (HOME groups); (2) immediately after rats were placed into a distinct environment (NOVEL groups); or (3) in a distinct environment, but after either 1 or 6-8 hr of habituation to that environment (1 hr and 6-8 hr HABITUA-TION groups). Intravenous injections of amphetamine were given using remote-controlled syringe pumps. Thus, amphetamine was administered in the absence of the aversive stimuli associated with other routes of experimental drug administration (e.g., appearance of an experimenter, handling, needle jab). MATERIALS AND METHODS Subjects and Behavioral MeasureMale Sprague-Dawley rats (Harlan Sprague Dawley, Indianapolis, IN), weighing 200-225 g on arrival were individu...

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“…Mice were individually placed in the Plexiglas activ ity cages and adapted to the cages for 30 min, and then the ambulatory activity was measured for 1.5 hr after the administration of ketamine (12.5, 25 and 50 mg/kg) or sa line. These treatments were repeated for 5 times at 3 to 4 day intervals, following the experimental protocol in our laboratory to exclude accumulative effects of the drug (5,6). In each drug test, 36-39 mice were used.…”

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confidence: 99%

The Repeated Administration of Ketamine Induces an Enhancement of Its Stimulant Action in Mice

Uchihashi¹,

Kuribara²,

Morita

et al. 1993

Japanese Journal of Pharmacology

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ABSTRACT-The modification of the stimulant and motor-incoordinate actions of ketamine induced by repeated administration was investigated by means of ambulatory activity and rota-rod performance in mice, respectively. Ketamine (12.5, 25 and 50 mg/kg, s.c.) increased the mouse's ambulation in a dose dependent manner, and the repeated 5-times administration at 3 to 4-day intervals enhanced the increment effect. However, a disruption of the rota-rod performance by ketamine was not modified by the repeated treatment. These results suggest that a reverse tolerance to the stimulant action of ketamine is produced, and that a tolerance to its motor-incoordinate action may not cause the enhancement.

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Enhancing effect of methamphetamine on ambulatory activity produced by repeated administration in mice

Cited by 130 publications

References 15 publications

Differential Sensitization to Ambulation-Increasing Effect of Methamphetamine after Repeated Administration to Mice in Activity Cages of Different Sizes

Differential Sensitization to Ambulation-Increasing Effect of Methamphetamine after Repeated Administration to Mice in Activity Cages of Different Sizes

The Ability of Environmental Context to Facilitate Psychomotor Sensitization to Amphetamine Can Be Dissociated from Its Effect on Acute Drug Responsiveness and on Conditioned Responding

The Repeated Administration of Ketamine Induces an Enhancement of Its Stimulant Action in Mice

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