2000
DOI: 10.1111/j.1349-7006.2000.tb00978.x
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Enhancing Effect of an Inhibitor of Nitric Oxide Synthesis on Bacillus Calmette‐Guérin‐induced Macrophage Cytotoxicity against Murine Bladder Cancer Cell Line MBT‐2 in vitro

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Cited by 19 publications
(24 citation statements)
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“…In a previous paper we have reported that BCG-induced macrophage-mediated cytotoxicity was regulated by soluble factors such as IFN-g and TNF-a [20]. We also found that IFN-g and TNF-a production by PEC were down-regulated by PGE 2 and up-regulated by COX inhibitors (Fig.…”
Section: Discussionsupporting
confidence: 60%
“…In a previous paper we have reported that BCG-induced macrophage-mediated cytotoxicity was regulated by soluble factors such as IFN-g and TNF-a [20]. We also found that IFN-g and TNF-a production by PEC were down-regulated by PGE 2 and up-regulated by COX inhibitors (Fig.…”
Section: Discussionsupporting
confidence: 60%
“…We previously demonstrated that macrophages exhibited cytotoxicity against MBT‐2 cells (a mouse bladder cancer line of C3H origin) in vitro upon BCG activation [46,47]. In these studies, PECs were used as a conventional source for macrophages.…”
Section: Discussionmentioning
confidence: 99%
“…Injection of cytostatics to macrophages, for example silica or antimacrophage serum, in vivo, could accelerate the growth of tumor (Irie, et al, 2005). However, the Bacille Calmette Guerin or coryne bacterium parvum could restrain tumor growth and metastasis by activated macrophages (Yamada et al, 2000;Luo et al, 2004). Pathology biopsy showed that if there were macrophages around the tumor tissue, the incidence rate of the tumor metastasis was lower and the prognosis showed better also.…”
Section: Discussionmentioning
confidence: 99%