Enhancing effect of aerobic training on learning and memory performance in rats after long-term treatment with Lacosamide via BDNF-TrkB signaling pathway

Shishmanova-Doseva, Michaela; Georgieva, Katerina; Koeva, Yvetta; Terzieva, Dora; Peychev, Lyudmil

doi:10.1016/j.bbr.2019.111963

Cited by 8 publications

(6 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 In the present study, we have demonstrated that LCM can produce different effects on inhibitory avoidance performance in intact rats and pilocarpine-treated rats. LCM adversely affected passive learning as well as the formation of short-and long-term memory traces in naive rats which is consistent with our previous studies 15,20 while in the epileptic animals, LCM improved the long-term memory performance suggesting that these AEDs exert a disease-modifying effect. As a new AED, there is little evidence for the side effects of LCM on different cognitive domains.…”

Section: Discussionsupporting

confidence: 91%

The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model

Shishmanova-Doseva¹,

Tchekalarova²,

Nenchovska³

et al. 2020

Self Cite

View full text Add to dashboard Cite

Introduction: Epilepsy and antiepileptic drugs can affect negatively the cognitive abilities of patients. Aim: The present study aimed to evaluate the effect of topiramate (TPM) and lacosamide (LCM) on the emotional and cognitive re-sponses in naive animals and in animals with pilocarpine-induced status epilepticus.  Materials and methods: Male Wistar rats were randomly divided into 6 groups and status epilepticus was evoked in half of them by a single i.p. administration of pilocarpine (Pilo) (320 mg/kg): Pilo-veh, Pilo-TPM (80 mg/kg) and Pilo-LCM (30 mg/kg). Matched naive rats were treated with the same doses as follows: C-veh, C-TPM, and C-LCM. In a step-down passive avoidance test, the learning session was held for one day, the early retention test was conducted on day 2, and the long-term memory test - on day 7. Motor activity and anxiety were evaluated in an open field test.  Results: The Pilo-TPM and Pilo-LCM groups increased the time spent on the platform compared to Pilo-veh animals while the C-LCM animals decreased the time compared to C-veh animals during short- and long-term memory retention tests. TPM and LCM exerted an anxiolytic effect in naive rats. The two antiepileptic drugs were unable to alleviate the hyperactivity, but they alleviated the impulsivity associated with decreased anxiety level in epileptic rats. Conclusions: Our findings suggest that LCM and TPM have a beneficial effect on cognition both in naive and epileptic rats. While the two antiepileptic drugs can produce an anxiolytic effect in naive rats, they alleviate the impulsivity after pilocarpine treatment.

show abstract

Section: Discussionsupporting

confidence: 91%

The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model

Shishmanova-Doseva¹,

Tchekalarova²,

Nenchovska³

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Rats were randomly divided into two groups: sedentary (sed) and exercised (ex). Exercised animals were trained on a treadmill (EXER-3R Treadmill, Columbus Instruments, Columbus, OH, USA) five days a week with a speed of 16 m/min, at a track elevation of 5° (about 55–60% of VO 2 max), for 4 weeks [ 57 , 58 ]. The exercise intensity was below the lactate steady state during the treadmill running, indicating that this type of training is aerobic [ 59 ].…”

Section: Materials and Methodsvmentioning

confidence: 99%

Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences

Shishmanova-Doseva

Georgieva²,

Uzunova³

et al. 2022

IJMS

View full text Add to dashboard Cite

Epilepsy is a brain disorder characterized by recurrent epileptic seizures and neurobiological, physiological, mood, and cognitive consequences. In the last decade, the beneficial effects of regular physical exercise have been investigated in patients with neurodegenerative diseases such as epilepsy. However, data on its beneficial effects and underlying mechanisms are still insufficient. The objective of the current study was to investigate the effects of endurance training, applied before and after pilocarpine (Pilo) administration, on status epilepticus (SE) severity, and its relation to epileptogenesis deleterious consequences during the chronic epileptic phase. Long-term aerobic training, applied four weeks before SE and eight weeks after SE, elevated the threshold to induce SE and reduced spontaneous motor seizures. The protective effect of this alternative approach on seizure susceptibility resulted in improved memory responses, and alleviated comorbid depression in epileptic rats. The exercised epileptic rats had improved markers of oxidative stress by decreasing lipid peroxidation and increasing the levels of glutathione and activity of superoxide dismutase in the rat hippocampus. Aerobic training managed to ameliorate the neuroinflammation by decreasing the levels of TNF-α and IL-1β in the hippocampus. Our results suggest that regular physical training predisposes the subjects to crucial plastic changes, leading to increased resistance to SE and the development of epileptogenesis.

show abstract

“…Epilepsy itself and most of the antiepileptic medications impair the cognitive functions [51], which requires the search for methods that complement the basic therapy to reduce cognitive deficits. Our previous experimental studies have shown that the regular physical exercise reduces the cognitive deficit from the application of antiepileptic medications and suppresses depression and anxiety behavior in epilepsy [44,51,52].…”

Section: Mental Healthmentioning

confidence: 98%

“…Some studies have reported a correlation between the decreased neurotrophin production and diseases, such as depression, schizophrenia, and dementia [43]. Rodent models have shown that increased physical activity elevates the expression of the brain-derived neurotrophic factor (BDNF) in the hippocampal and cortical areas, and it has been related to the improvement of cognitive function, including memory [44]. Both acute, high-intensity activity and regular, moderate aerobic exercise have been reported to increase the levels of circulating neurotrophic factors and enhance neurotransmission, exerting beneficial effects on mood and cognitive functions in individuals of all ages.…”

Section: Mental Healthmentioning

confidence: 99%

Outdoor Recreation: Physiological Effects and Prevention of Socially Important Diseases

Boyadjiev¹,

Georgieva²,

Hristova³

2021

Outdoor Recreation - Physiological and Psychological Effects on Health

View full text Add to dashboard Cite

Physical activity improves the condition of the cardiovascular system, respiration, muscles, and metabolism and increases physical working capacity. This review of physiological effects and adaptation mechanisms of the outdoor recreation and its health benefits provides accessible information from a scientific point of view and research practice. Increased frequency of many socially important diseases such as diabetes mellitus type 2, metabolic syndrome and obesity, cardiovascular diseases, and others is associated with dramatically decreased physical activity in the last decades. Outdoor recreation for children, adolescents, adults, and older population is important for the prevention of these conditions. In this chapter, the authors describe in detail the physiological effects of different kinds of outdoor recreation physical activity with different intensities (such as walking, cycling, skiing, rowing, climbing, practicing some outdoor sports, etc.) and assess their benefits in the prevention of socially important diseases.

show abstract

Enhancing effect of aerobic training on learning and memory performance in rats after long-term treatment with Lacosamide via BDNF-TrkB signaling pathway

Cited by 8 publications

References 66 publications

The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model

The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model

Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences

Outdoor Recreation: Physiological Effects and Prevention of Socially Important Diseases

Contact Info

Product

Resources

About

Enhancing effect of aerobic training on learning and memory performance in rats after long-term treatment with Lacosamide via BDNF-TrkB signaling pathway

Cited by 8 publications

References 66 publications

The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status&nbsp;Epilepticus Rat Model

The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status&nbsp;Epilepticus Rat Model

Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences

Outdoor Recreation: Physiological Effects and Prevention of Socially Important Diseases

Contact Info

Product

Resources

About

The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model

The Effect of Chronic Treatment with Lacosamide and Topiramate on Cognitive Functions and Impaired Emotional Responses in a Pilocarpine-induced Post-status Epilepticus Rat Model