Abstract:BACKGROUND AND PURPOSE Enhancing the precision of drug-drug
interaction (DDI) prediction is essential for mitigating potential drug
interactions and enhancing drug safety and efficacy. This study aims to
investigate the impact of in vitro and in silico approaches for
calculating the fraction metabolized by CY3A4 (fm) on DDI prediction
accuracy and identified the most effective method for improving DDI
prediction using physiologically based pharmacokinetic (PBPK) models.
EXPERIMENTAL APPROACH Both in vitro and … Show more
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