Enhancing CAR T cells function: role of immunomodulators in cancer immunotherapy
Maheen Rehman,
Ariba Qaiser,
Hassan Sardar Khan
et al.
Abstract:CAR T-cell therapy is a promising immunotherapy, providing successful results for cancer patients who are unresponsive to standard and traditional therapeutic approaches. However, there are limiting factors which create a hurdle in the therapy performing its role optimally. CAR T cells get exhausted, produce active antitumor responses, and might even produce toxic reactions. Specifically, in the case of solid tumors, chimeric antigen receptor T (CAR-T) cells fail to produce the desired outcomes. Then, the need… Show more
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