Enhancing cancer therapy: The potential of mercaptopurine-based nanomaterials for targeted drug delivery

Pourmadadi, Mehrab; Ghohrodi, Arsalan Rahmani; Savari, Zeinab; Talebi, Ehsan; Ahamdi, Iman; Rahdar, Abbas; Pandey, Sadanand

doi:10.1016/j.nxnano.2023.100018

Cited by 2 publications

(2 citation statements)

References 156 publications

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“…A composite of chitosan-dispersed gold nanoparticles (AuNPs) was synthesized to load 6-mercaptopurine (6MP), a therapeutic agent employed in the treatment of cancerous solid tumors [94]. Faid et al [88] developed chitosan-encapsulated 6MP with subsequent loading on AuNPs to form 6MP-CNPs-AuNPs nanocomposites, as depicted in Figure 6.…”

Section: Chitosan-aunps For 6-mercaptopurine (6mp) Deliverymentioning

confidence: 99%

Recent Advancements in Metallic Au- and Ag-Based Chitosan Nanocomposite Derivatives for Enhanced Anticancer Drug Delivery

El-Meligy,

Abd El-Monaem,

Eltaweil

et al. 2024

Molecules

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The rapid advancements in nanotechnology in the field of nanomedicine have the potential to significantly enhance therapeutic strategies for cancer treatment. There is considerable promise for enhancing the efficacy of cancer therapy through the manufacture of innovative nanocomposite materials. Metallic nanoparticles have been found to enhance the release of anticancer medications that are loaded onto them, resulting in a sustained release, hence reducing the dosage required for drug administration and preventing their buildup in healthy cells. The combination of nanotechnology with biocompatible materials offers new prospects for the development of advanced therapies that exhibit enhanced selectivity, reduced adverse effects, and improved patient outcomes. Chitosan (CS), a polysaccharide possessing distinct physicochemical properties, exhibits favorable attributes for controlled drug delivery due to its biocompatibility and biodegradability. Chitosan nanocomposites exhibit heightened stability, improved biocompatibility, and prolonged release characteristics for anticancer medicines. The incorporation of gold (Au) nanoparticles into the chitosan nanocomposite results in the manifestation of photothermal characteristics, whereas the inclusion of silver (Ag) nanoparticles boosts the antibacterial capabilities of the synthesized nanocomposite. The objective of this review is to investigate the recent progress in the utilization of Ag and Au nanoparticles, or a combination thereof, within a chitosan matrix or its modified derivatives for the purpose of anticancer drug delivery. The research findings for the potential of a chitosan nanocomposite to deliver various anticancer drugs, such as doxorubicin, 5-Fluroacil, curcumin, paclitaxel, and 6-mercaptopurine, were investigated. Moreover, various modifications carried out on the chitosan matrix phase and the nanocomposite surfaces to enhance targeting selectivity, loading efficiency, and pH sensitivity were highlighted. In addition, challenges and perspectives that could motivate further research related to the applications of chitosan nanocomposites in cancer therapy were summarized.

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Section: Chitosan-aunps For 6-mercaptopurine (6mp) Deliverymentioning

confidence: 99%

Recent Advancements in Metallic Au- and Ag-Based Chitosan Nanocomposite Derivatives for Enhanced Anticancer Drug Delivery

El-Meligy,

Abd El-Monaem,

Eltaweil

et al. 2024

Molecules

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“…Nanoformulations based on polymers, proteins, lipids, metals, or inorganic materials have been extensively developed over the years. [1][2][3] These formulations exhibit good bioavailability, targeting capacity, and the ability to enhance drug stability, 3 demonstrating the promising future of nanomedicine in mediating detection and treatment of a wide range of disorders. [4][5][6][7] Among different types of nanoparticles (NPs), metallic nanoparticles generally exhibit high biocompatibility, low toxicity, and high structural stability.…”

Section: Introductionmentioning

confidence: 99%

Composite Microgels Loaded with Doxorubicin-Conjugated Amine-Functionalized Zinc Ferrite Nanoparticles for Stimuli-Responsive Sustained Drug Release

Bellala,

Viswanathan,

Guntakanti

et al. 2024

IJN

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Purpose The purpose of this study is to address the need for efficient drug delivery with high drug encapsulation efficiency and sustained drug release. We aim to create nanoparticle-loaded microgels for potential applications in treatment development. Methods We adopted the process of ionic gelation to generate microgels from sodium alginate and carboxymethyl cellulose. These microgels were loaded with doxorubicin-conjugated amine-functionalized zinc ferrite nanoparticles (AZnFe-NPs). The systems were characterized using various techniques. Toxicity was evaluated in MCF-7 cells. In vitro release studies were conducted at different pH levels at 37 o C, with the drug release kinetics being analyzed using various models. Results The drug encapsulation efficiency of the created carriers was as high as 70%. The nanoparticle-loaded microgels exhibited pH-responsive behavior and sustained drug release. Drug release from them was mediated via a non-Fickian type of diffusion. Conclusion Given their high drug encapsulation efficiency, sustained drug release and pH-responsiveness, our nanoparticle-loaded microgels show promise as smart carriers for future treatment applications. Further development and research can significantly benefit the field of drug delivery and treatment development.

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Enhancing cancer therapy: The potential of mercaptopurine-based nanomaterials for targeted drug delivery

Cited by 2 publications

References 156 publications

Recent Advancements in Metallic Au- and Ag-Based Chitosan Nanocomposite Derivatives for Enhanced Anticancer Drug Delivery

Recent Advancements in Metallic Au- and Ag-Based Chitosan Nanocomposite Derivatives for Enhanced Anticancer Drug Delivery

Composite Microgels Loaded with Doxorubicin-Conjugated Amine-Functionalized Zinc Ferrite Nanoparticles for Stimuli-Responsive Sustained Drug Release

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