Enhancing bone healing during distraction osteogenesis with platelet-rich plasma

Latalski, M; Elbatrawy, Yasser; Thabet, Ahmed M.; Gregosiewicz, A; Raganowicz, Tomasz; Fatyga, Marek

doi:10.1016/j.injury.2011.03.010

Cited by 44 publications

(31 citation statements)

References 26 publications

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“…Thus, the Ilizarov technique has been considered a time-consuming procedure, with the additional disadvantages of complicated frame arrangement, pin tract infection, and lack of patient and parent compliance [9]. The duration of frame application can be shortened by increasing the distraction rate or by using a method other than the Ilizarov frame to maintain the correction during the consolidation phase [14]. Increasing the distraction rate has been associated with pain and severe swelling of the foot, skin sloughing, and neurovascular complications [17].…”

Section: Introductionmentioning

confidence: 99%

Does Short-term Application of an Ilizarov Frame with Transfixion Pins Correct Relapsed Clubfoot in Children?

Refai

Song

2012

Clinical Orthopaedics &Amp; Related Research

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Background Treatment of relapsed clubfoot after soft tissue release in children is difficult because of the high recurrence rate and related complications. Even though the Ilizarov method is used for soft tissue distraction, there is a high incidence of recurrence after removal of the Ilizarov frame owing to previous contracture of soft tissue and a skin scar. Questions/Purposes We asked (1) whether transfixation of midfoot joints by temporary K wires during the consolidation stage after short-term application of an Ilizarov frame would maintain correction of the relapsed clubfoot clinicoradiologically and (2) whether this method would reduce the rate of recurrence and related complications in patients with a skin scar from previous surgery.

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Section: Introductionmentioning

confidence: 99%

Does Short-term Application of an Ilizarov Frame with Transfixion Pins Correct Relapsed Clubfoot in Children?

Refai

Song

2012

Clinical Orthopaedics &Amp; Related Research

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“…Various approaches have been studied to accelerate the process of bone formation and consolidation in distraction osteogenesis including low-intensity pulsed ultrasound [5], systemic use of bisphosphonates [10] and parathyroid hormone [17], local application of various potent bone anabolic agents such as BMPs [22,23], VEGF [25], transforming growth factor-b [29], basic fibroblast growth factor [16], IGF-1 [30], and platelet-rich plasma [20], and local transplantation of bone mesenchymal stem cells [28,31] and gene therapy [12]. However, the effects of these approaches on distraction osteogenesis remain controversial and none of the interventions has proven to be clinically effective.…”

Section: Introductionmentioning

confidence: 99%

Bone Regeneration Is Promoted by Orally Administered Bovine Lactoferrin in a Rabbit Tibial Distraction Osteogenesis Model

Zhu

2015

Clinical Orthopaedics &Amp; Related Research

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Background Lactoferrin, an iron-binding glycoprotein which belongs to the transferrin family, has been shown to promote bone growth. However, reports regarding effects of lactoferrin on bone regeneration during distraction osteogenesis are limited. Our study was designed to investigate the effect of bovine lactoferrin treatment on bone formation of the distracted callus. Questions/purposes We asked whether bovine lactoferrin enhances bone formation of the distraction callus as determined by (1) radiographic and histologic appearances; (2) dual-energy x-ray absorptiometry (DXA) analysis of bone mineral composition and bone mineral density; (3) micro-CT measures of trabecular architecture; and (4) biomechanical strength of the healing bone. Additionally, serology, reverse transcription (RT)-PCR, and immunohistochemistry were used to explore the possible mechanisms of bovine lactoferrin use on bone formation during distraction osteogenesis. Methods Unilateral tibial osteodistraction was performed on 80 New Zealand White rabbits with a distraction rate of 1 mm per day for 10 days. Animals then were divided randomly into two groups: (1) vehicle and (2) bovine lactoferrin. At 4 and 8 weeks after completion of distraction, the animals were sacrificed. Lengthened tibias and serum samples were obtained and subjected to radiologic, DXA, micro-CT, histologic, and biomechanical examinations, and serum, RT-PCR and immunohistochemical analyses. Results Radiologic, DXA, micro-CT, histologic, and biomechanical examinations indicated that bovine lactoferrin treatment not only accelerated bone formation at early stages of distraction osteogenesis but also promoted bone consolidation at late stages. The ultimate force of the distracted calluses was increased by 37% (118.8 ± 6.65 N in the lactoferrin group and 86.5 ± 5.47 N in the vehicle group; p \ 0.001) and 84% (384.8 ± 18.4 N in the lactoferrin group and 209.0 ± 15.2 N in the vehicle group; p \ 0.001) at 4 and 8 weeks, respectively. Moreover, serum analysis showed that bovine lactoferrin treatment significantly increased serum levels of bone alkaline phosphatase and decreased serum levels of tartrate resistant acid phosphatase 5b. In addition, RT-PCR and immunohistochemical analyses suggested that bovine lactoferrin treatment induced a lower receptor activator of nuclear

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“…In addition, several methods for enhancement of bone formation in distraction osteogenesis have been reported, including physical stimulations and local or systemic applications [9,16,17,28,30,33,42]. Several physical stimulations have been considered effective in enhancing bone formation in distraction osteogenesis, such as the axial compression (weightbearing) method, the accordion maneuver (repeated overlengthening and then compression), and low-intensity pulsed ultrasound [20,22,40,41,50], which has been reported to be especially effective in acute fracture, nonunion, and distraction osteogenesis but still lacks controlled studies in distraction osteogenesis [16,32,50].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, there has been a growing interest in biologic stimulations to enhance bone regenerate [6,9,28,30,33,36,43,44,60]. Local application of bone marrow cells, platelet-rich plasma (PRP), demineralized bone matrix, and BMP have been tried in experimental distraction osteogenesis models [9,30,33,60].…”

Section: Introductionmentioning

confidence: 99%

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Bone Marrow Aspirate Concentrate and Platelet-rich Plasma Enhanced Bone Healing in Distraction Osteogenesis of the Tibia

Lee¹,

Ryu²,

Kim³

et al. 2014

Clin Orthop Relat Res

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Background During lower limb lengthening, poor bone regeneration is a devastating complication. Several local or systemic applications have been used to promote osteogenesis, and biologic stimulations are gaining attention, but their utility has not been proven in this setting. Questions/purposes In patients undergoing bilateral tibial lengthening, we compared those receiving an osteotomy site injection of autologous bone marrow aspirate concentrate (BMAC) plus platelet-rich plasma (PRP) with those not receiving such an injection in terms of external fixator index (time in external fixation divided by amount of lengthening), full weightbearing index (time until a patient was permitted to do full weightbearing divided by amount of lengthening), four cortical healing indexes (time until each cortical union divided by amount of lengthening), and callus shape and type. Methods Twenty-two patients (44 tibias) undergoing bilateral tibial lengthening enrolled in this randomized trial. Two patients were excluded, one due to insufficient radiographic evaluation and one who was lost to followup, leaving 20 patients (40 segments) for inclusion. Ten patients (20 segments) received BMAC combined with PRP injection (treatment group) and 10 patients (20 segments) received no injection (control group). All patients underwent stature lengthening for familial short stature with the lengthening over nail technique. Autologous BMAC combined with PRP was injected at the tibial osteotomy site at the end of the index surgery. Mean distraction rates were similar between groups (0.75 mm/day in the treatment group versus 0.72 mm/day in the control group; p = 0.24). Full weightbearing was permitted when we observed radiographic evidence of healing at two cortices; this assessment was made by the surgeon who was blinded to the treatment each patient received. Minimum followup was 24 months (mean, 28 months; range, 24-34 months).

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Enhancing bone healing during distraction osteogenesis with platelet-rich plasma

Cited by 44 publications

References 26 publications

Does Short-term Application of an Ilizarov Frame with Transfixion Pins Correct Relapsed Clubfoot in Children?

Does Short-term Application of an Ilizarov Frame with Transfixion Pins Correct Relapsed Clubfoot in Children?

Bone Regeneration Is Promoted by Orally Administered Bovine Lactoferrin in a Rabbit Tibial Distraction Osteogenesis Model

Bone Marrow Aspirate Concentrate and Platelet-rich Plasma Enhanced Bone Healing in Distraction Osteogenesis of the Tibia

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