Enhancing biological activity of bioactive glass scaffolds by inorganic ion delivery for bone tissue engineering

Mouriño, Viviana; Vidotto, R.; Cattalini, Juan Pablo; Boccaccını, Aldo R.

doi:10.1016/j.cobme.2019.02.002

Cited by 42 publications

(28 citation statements)

References 79 publications

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“…Bioactive glasses are attracting considerable attention for regenerative medicine and tissue engineering applications due to their excellent features in terms of bioactivity, biodegradability [ 378 ], osteogenesis [ 51 ], angiogenesis [ 11 ], antibacterial [ 95 ], anti-inflammatory [ 379 ], and immunomodulatory effects [ 380 , 381 ]. The field of ion releasing BGs for biomedical applications has been growing in the last 20 years, and several comprehensive reviews on different aspects of ion releasing BGs for biomedical use are available [ 39 – 41 , 49 , 53 , 54 ]. More recently, BG compositions incorporating exotic (“exotic” in the sense that such ions are not obviously linked to a biomedical use due to a possible biological activity) or less-common ions have started to be investigated.…”

Section: Discussionmentioning

confidence: 99%

“…The use of several biologically active ions has been prevalent in recent years, namely, Ag + , Li + , Co 2+ , Ca 2+ , Cu 2+ , Zn 2+ , Sr 2+ , Fe 2+ , Mg 2+ , Ga 3+ , and B 3+ have been added to silicate, phosphate, and borate BG systems to promote functional properties such as osteogenesis, angiogenesis, bioactivity, antibacterial effects, and immunomodulation for tissue regeneration, as well as for infection and cancer treatment [ 40 , 47 , 48 ]. Several comprehensive reviews on such BGs incorporating “common” biologically active ions are available [ 8 , 15 , 31 , 39 – 42 , 49 – 54 ].…”

Section: Introductionmentioning

confidence: 99%

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Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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“…The ability to release bioactive ions during degradation is one of the most important features of these bioglasses ( Mouriño et al, 2019 ). For instance, it is known that the early vascularization of biomaterials plays an essential role in bone regeneration ( Almubarak et al, 2016 ).…”

Section: Mimicking Bone Composition: Bioceramics and Composite Nanostmentioning

confidence: 99%

Nanostructured Biomaterials for Bone Regeneration

Lyons

Plantz

Hsu

et al. 2020

Front. Bioeng. Biotechnol.

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This review article addresses the various aspects of nano-biomaterials used in or being pursued for the purpose of promoting bone regeneration. In the last decade, significant growth in the fields of polymer sciences, nanotechnology, and biotechnology has resulted in the development of new nano-biomaterials. These are extensively explored as drug delivery carriers and as implantable devices. At the interface of nanomaterials and biological systems, the organic and synthetic worlds have merged over the past two decades, forming a new scientific field incorporating nano-material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions and influence function, while also considering safety. While there is still much to learn about the bio-physicochemical interactions at the interface, we are at a point where pockets of accumulated knowledge can provide a conceptual framework to guide further exploration and inform future product development. This review is intended as a resource for academics, scientists, and physicians working in the field of orthopedics and bone repair.

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“…Studies have shown that several inorganic nutrient ions (Zn 2+ , Sr 2 + , Co 2+ , etc.) revealed positive effects on osteogenesis and angiogenesis 14 . Co 2+ is a metal ion and a vital trace element for humans that functions as a cofactor in vitamin‐B12‐dependent 15 …”

Section: Introductionmentioning

confidence: 99%

Immobilization of cobalt‐loaded laponite/carboxymethyl chitosan on polycaprolactone nanofiber for improving osteogenesis and angiogenesis activities

Arab‐Ahmadi

Irani

Bakhshi

et al. 2021

Polymers for Advanced Techs

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Designing scaffolds with therapeutic potential to stimulate angiogenesis and osteogenesis is considered a promising strategy in the regeneration of large skeletal defects. In this study, the cobalt ions (Co2+) were incorporated in laponite (LAP) nanodiscs (0.65, 1.3, and 2.6 g/L) and, in combination with carboxymethyl chitosan (CMC), were immobilized on the electrospun polycaprolactone (PCL) nanofiber to fabricate scaffolds for simultaneous enhancing osteogenesis and angiogenesis inductions to human bone marrow mesenchymal stem cells. The Fourier transform infrared, energy dispersive X‐ray, and inductively coupled plasma atomic emission spectrometries confirmed the Co2+‐loading on the LAP nanodiscs and the chemical immobilization on the surface of PCL nanofibers. The result of MTT assay, scanning electron microscopy, and fluorescence staining displayed that Co2+‐loaded scaffolds were biocompatible. Furthermore, the incorporation of Co2+ ions into LAP nanodiscs had significant effects on the calcium deposition and expression of osteogenic markers, alkaline phosphatase and osteonectin, as well as, the expression of angiogenic markers, hypoxia‐inducible factor‐1α and vascular endothelial growth factor of the cells seeded on the scaffolds (p ≤ 0.05). These results suggested that the combination of Co2+ ions with CMC/LAP could result in a synergetic effect on the osteogenesis and angiogenesis stimulations.

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Enhancing biological activity of bioactive glass scaffolds by inorganic ion delivery for bone tissue engineering

Cited by 42 publications

References 79 publications

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Nanostructured Biomaterials for Bone Regeneration

Immobilization of cobalt‐loaded laponite/carboxymethyl chitosan on polycaprolactone nanofiber for improving osteogenesis and angiogenesis activities

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