Enhancing anticancer activity of macrophages through rational drug combinations
Gordon B. Mills,
Marilyne Labrie
Abstract:Targeting tumor-associated macrophages (TAMs) is an emerging approach being tested in multiple clinical trials. TAMs, depending on their differentiation state, can exhibit pro- or antitumorigenic functions. For example, the M2-like phenotype represents a protumoral state that can stimulate tumor growth, angiogenesis, metastasis, therapy resistance, and immune evasion by expressing immune checkpoint proteins. In this issue of the
JCI
, Vaccaro and colleagues utilized an innovative drug sc… Show more
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