Enhancements in the Techa River Dosimetry System: TRDS-2016D Code for Reconstruction of Deterministic Estimates of Dose From Environmental Exposures

Дегтева, М. О.; Napier, Bruce A.; Толстых, Е. И.; Shishkina, E.A.; Shagina, N. B.; Volchkova, A Yu; Bougrov, N. G.; Smith, Michael A.; Anspaugh, L.R.

doi:10.1097/hp.0000000000001067

Cited by 48 publications

(14 citation statements)

References 22 publications

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“…Reviewing Table 1 data, total femoral marrow dose is an age-dependent fraction of total skeletal marrow dose. In addition, the DF examples do not reflect the total dose rate in AM , which was also determined by the contributions from ingested 89 Sr and 137 Cs, as well as external exposure of the whole body [ 4 ]. Thus, for the future analysis of the excess relative risk of leukemia observed in the Techa River cohorts, together with the 90 Sr doses shown here, the total doses from all exposure pathways will be estimated.…”

Section: Discussionmentioning

confidence: 99%

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Stochastic parametric skeletal dosimetry model for humans: General approach and application to active marrow exposure from bone-seeking beta-particle emitters

et al. 2021

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The objective of this study is to develop a skeleton model for assessing active marrow dose from bone-seeking beta-emitting radionuclides. This article explains the modeling methodology which accounts for individual variability of the macro- and microstructure of bone tissue. Bone sites with active hematopoiesis are assessed by dividing them into small segments described by simple geometric shapes. Spongiosa, which fills the segments, is modeled as an isotropic three-dimensional grid (framework) of rod-like trabeculae that “run through” the bone marrow. Randomized multiple framework deformations are simulated by changing the positions of the grid nodes and the thickness of the rods. Model grid parameters are selected in accordance with the parameters of spongiosa microstructures taken from the published papers. Stochastic modeling of radiation transport in heterogeneous media simulating the distribution of bone tissue and marrow in each of the segments is performed by Monte Carlo methods. Model output for the human femur at different ages is provided as an example. The uncertainty of dosimetric characteristics associated with individual variability of bone structure was evaluated. An advantage of this methodology for the calculation of doses absorbed in the marrow from bone-seeking radionuclides is that it does not require additional studies of autopsy material. The biokinetic model results will be used in the future to calculate individual doses to members of a cohort exposed to 89,90Sr from liquid radioactive waste discharged to the Techa River by the Mayak Production Association in 1949–1956. Further study of these unique cohorts provides an opportunity to gain more in-depth knowledge about the effects of chronic radiation on the hematopoietic system. In addition, the proposed model can be used to assess the doses to active marrow under any other scenarios of 90Sr and 89Sr intake to humans.

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Section: Discussionmentioning

confidence: 99%

“…Evaluation of individual dose and associated uncertainty from ingested 90 Sr and also the shorter-lived 89 Sr is of utmost importance in the dosimetric support of the epidemiological studies [ 4 ]. Strontium-90 was the most significant radionuclide for the exposed residents in terms of bone marrow dose.…”

Section: Introductionmentioning

confidence: 99%

Stochastic parametric skeletal dosimetry model for humans: General approach and application to active marrow exposure from bone-seeking beta-particle emitters

et al. 2021

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“…The study engaged 309 people with dose to RBM reconstructed with the Techa River Dosimetry System 2016 (TRDS 2016) (Degteva et al, 2019). The main group of exposed people included 163 persons with individual accumulated doses to RBM within the dose range 78-3510 mGy.…”

Section: Methodsmentioning

confidence: 99%

Single nucleotide polymorphism and expression of genes for immune competent cell proliferation and differentiation in radiation-exposed individuals

Блинова

et al. 2020

Vestn. VOGiS

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It is known that ionizing radiation influences the expression of the genes that play a key role in the mechanisms of maintaining the stability of cellular homeostasis. As a rule, changes in the transcriptome of an exposed cell occur within the first 24 hours following radiation exposure. And it predetermines early response in the case of genome damage. Later on modulations in gene transcription activity are also possible and could result in a carcinogenic effect. However, in order to find the role of exogenous factors (ionizing radiation), it is also necessary to take into account the contribution of endogenous factors that are able to modify gene transcription activity. This is especially important for long after the onset of radiation exposure. Single nucleotide polymorphisms located in regulatory regions of the genes may belong to this group of factors. The objective of the current study was to analyze the influence of ionizing radiation on the transcription activity of the STAT3, GATA3, NFkB1, PADI4 genes, which regulate proliferation and differentiation of immune competent human cells; and to assess the potential influence of single nucleotide polymorphisms located in regulatory regions of the genes on the amount of mRNA. The study involved people who had been chronically exposed due to releases of radioactive waste into the Techa River. It was observed that 60 years after the onset of radiation exposure changes in the transcription activity of the NFkB1 and PADI4 genes were registered in people with cumulative doses to RBM within the range 78–3510 mGy. In people who had been chronically exposed, the effect of allelic variations in rs1053023, rs4143094, rs28362491, rs874881 on the level of mRNAs of the STAT3, GATA3, PADI4, NFkB1 genes has not been established.

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“…Absorbed doses in red bone marrow (RBM) significantly exceeded doses in stomach and other extraskeletal tissues due to the incorporation of 90 Sr in mineral bone. Individual dose values in the extended Techa River Cohort (TRC) varied over a wide range, with 10% of the TRC members having received doses exceeding 0.1–0.2 Gy to extraskeletal tissues and 0.9 Gy to RBM, and the maximum doses were about 1–2 Gy to extraskeletal tissues, and about 7 Gy to the RBM ( Degteva et al, 2019 ).…”

Section: Technical Areasmentioning

confidence: 99%

Public health response and medical management of internal contamination in past radiological or nuclear incidents: A narrative review

Reis

Ansari

et al. 2022

Environment International

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Enhancements in the Techa River Dosimetry System: TRDS-2016D Code for Reconstruction of Deterministic Estimates of Dose From Environmental Exposures

Cited by 48 publications

References 22 publications

Stochastic parametric skeletal dosimetry model for humans: General approach and application to active marrow exposure from bone-seeking beta-particle emitters

Stochastic parametric skeletal dosimetry model for humans: General approach and application to active marrow exposure from bone-seeking beta-particle emitters

Single nucleotide polymorphism and expression of genes for immune competent cell proliferation and differentiation in radiation-exposed individuals

Public health response and medical management of internal contamination in past radiological or nuclear incidents: A narrative review

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