Enhancement of vincristine sensitivity in retinoblastoma through Janus kinase inhibition by ruxolitinib
Feng Ke,
Nan Wang,
Xuan Zhang
et al.
Abstract:Chemotherapy remains the main approach conserving vision during the treatment of retinoblastoma, the most prevalent eye cancer in children. Unfortunately, the development of chemoresistance stands as the primary reason for treatment failure. Within this study, we showed that prolonged exposure to vincristine led to heightened expression of JAK1 and JAK2 in retinoblastoma cells, while the other members of the JAK family exhibited no such changes. Employing a genetic intervention, we demonstrated the efficacy of… Show more
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