In this paper, the cooling calculation and analysis of the flat plate structure containing internal heat source is carried out, and a relatively complete calculation model consisting of continuous phase control equation, discrete phase equation and mass, momentum and energy conservation equations of liquid film is established, which realizes the calculation simulation that can be applied to the cooling heat transfer of water spray in large space. Calculations show that the trend of calculated results in this paper and the experimental data are consistent. The maximum difference between the average water film temperature and the measured temperature on the infrared imager is 1.9°C, and the maximum difference between the calculated temperature of the flat plate and the 9-point average temperature of the thermocouple is 0.9°C. The water spray cooling of the flat plate is calculated to reduce the temperature of the experiment plate by 16.5℃ in 34 seconds, and the infrared radiance of 3~5μm is reduced by 45.5%, the infrared radiance of 8~12μm is reduced by 24.2%. The water spray cooling has a significant effect on the infrared characteristics of the plate.