Enhancement of undecylprodigiosin production from marine endophytic recombinant strain Streptomyces sp. ALAA-R20 through low-cost induction strategy

Alzahrani, Nourah Hassan; El-Bondkly, Alaa Ahmed Mohamed; El-Gendy, Mervat Morsy Abbas Ahmed; El-Bondkly, Ahmed Mohamed Ahmed

doi:10.1007/s13353-020-00597-x

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…Also, Felhi et al [15] study revealed that the aerial parts extracted from T. hirsuta exhibited moderate to strong antimicrobial effects against bacteria and yeasts. While the various constituents of medicinal plants have long been prescribed to treat various infectious diseases, there is little information available regarding their use in fungal skin infections [1,6,63]. Among all plants under study, ethyl acetate extracts showed the lowest inhibitory activity against all dermatophytes isolates, but ethanol extracts showed the highest antifungal activity.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening, Antifungal, and Anticancer Activities of Medicinal Plants Thymelaea Hirsuta, Urginea Maritima, and Plantago Albicans

El-Bondkly

Shammari

El-Gendy

et al. 2022

BioMed Research International

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Ethyl acetate, ethanol, and acetone extracts of the medicinal plants Thymelaea hirsuta L., Urginea maritima L., and Plantago albicans L. (aerial parts) were evaluated for their phytochemical compositions, antimycotic activity against dermatophytes, and antiproliferative activity against different human cancer cell lines. Among them, the ethanolic extracts showed the highest phytochemical contents along with hyperactivities and were then selected for gas chromatography-mass spectrometry and Fourier-transform infrared spectroscopy analysis. The Fourier-transform infrared spectroscopy analysis confirmed the presence of different characteristic peak values with various functional chemical groups of the active components. However, U. maritima extracts through Fourier-transform infrared spectroscopy analysis showed distinctive peaks related to phenolic, amines, amides, aromatic, alkanes, alkyne, cyclopentanone, conjugated aldehyde, nitro, methoxy, uronic acids, aromatic esters, tertiary alcohol or ester, secondary and primary alcohols, aliphatic ether, sulfoxide, vinylidene, and halo compounds. Many bioactive main compounds with reported biological activities were detected by GC/MS (%) in the ethanolic extract of T. hirsuta, U. maritima, and P. albicans. All studied dermatophytes included a diverse set of virulence factors, including phospholipase, protease, keratinase, hemolysis, and melanoid production, all of which play vital roles in dermatophytic infection. Ethanolic extract of P. albicans inhibited the growth of Trichophyton soudanense totally and Trichophyton erinacei in addition to all Microsporum species. In contrast, the ethanolic extract of Trichophyton hirsuta at concentrations of 25 g/mL totally prevented the growth of all Trichophyton species. EtOH extract of U. maritima completely prevented the growth (100% inhibition) of all dermatophytic strains under study at the lowest concentration of 12.5 μg/mL. Scanning electron microscope analysis revealed considerable morphological modifications and structural alterations in dermatophyte species exposed to ethanolic extract of these plants. The viability of HCT-116, HepG-2, MCF-7, and HeLa cell lines was reduced after treatment with the ethanolic extracts of T. hirsuta, U. maritima, and P. albicans individually with IC50 values (10.0, 9.97, 48.5, and 56.24 μg/mL), (26.98, 25.0, 17.11, and 9.52 μg/mL), and (9.32, 7.46, 12.50, and 16.32 μg/mL), respectively. Our work revealed the significance of these traditional ethnomedical plants as potent sources for biologically active pharmaceuticals with potential applicability for the treatment of fungal and cancer diseases.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Screening, Antifungal, and Anticancer Activities of Medicinal Plants Thymelaea Hirsuta, Urginea Maritima, and Plantago Albicans

El-Bondkly

Shammari

El-Gendy

et al. 2022

BioMed Research International

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“…Moreover, Undecylprodigiosin showcased relatively low MBC and MFC values against these MDR pathogens (< 8 μg/mL), revealing its potential cidal action against the said microbes. 86 However, Red Sea bacteria do not only inhabit corals and sponges, but they also live as endophytes/epiphytes of algae such as in the case of Nocardia sp. ALAA 2000 inhabiting the marine red alga Laurenica spectabilis , which was collected off the coast of Ras-Gharib, Egypt.…”

Section: Pure Compoundsmentioning

confidence: 99%

Antimicrobial Natural Products Derived from Microorganisms Inhabiting the MENA Region

Awada

Chahine

Derbaj

et al. 2023

Natural Product Communications

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Objective/Background Natural products (NPs) derived from microorganisms are the basis of a plethora of clinically utilized medications, namely, antimicrobial remedies. Although these secondary metabolites have been extensively explored all over the planet, they remain understudied in the Middle East and North Africa (MENA) region. Methods A literature search was conducted to first find NPs that were isolated from environmental fungi and bacteria that inhabit the soils and seawater of the MENA region. Then, purified molecules with biological activity against pathogenic bacteria, biofilms, fungi, and parasites were described in terms of structure, function, and location. Moreover, the methods that could be used to ameliorate the discovery of novel NPs from this region were investigated. Results A multitude of antimicrobial molecules from various chemical classes were found to be derived from the environmental microbes of MENA. Although many were rediscovered, some represented novel structural scaffolds for novel families of antimicrobial agents. Additionally, the geographical distribution showed a high number of these NPs were unraveled in a restricted area leaving much of MENA untapped. Furthermore, as relatively traditional and low-efficiency methods were typically used in the discovery process, advanced high-throughput techniques were suggested to enhance this practice at the regional level. Conclusion MENA represents a fairly unexploited region where antimicrobial drug discovery could be performed comprehensively through the concomitant exploration of untouched geographical locations and advanced molecular techniques.

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Structures, biosynthesis, and bioactivities of prodiginine natural products

Zhang

et al. 2022

Appl Microbiol Biotechnol

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Enhancement of undecylprodigiosin production from marine endophytic recombinant strain Streptomyces sp. ALAA-R20 through low-cost induction strategy

Cited by 5 publications

References 46 publications

Phytochemical Screening, Antifungal, and Anticancer Activities of Medicinal Plants Thymelaea Hirsuta, Urginea Maritima, and Plantago Albicans

Phytochemical Screening, Antifungal, and Anticancer Activities of Medicinal Plants Thymelaea Hirsuta, Urginea Maritima, and Plantago Albicans

Antimicrobial Natural Products Derived from Microorganisms Inhabiting the MENA Region

Structures, biosynthesis, and bioactivities of prodiginine natural products

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