Enhancement of transfection activity in HEK293 cells by lipoplexes containing cholesteryl nitrogen-pivoted aza-crown ethers

Sewbalas, Alisha; Islam, Rafique Ul; Otterlo, Willem A. L. van; Koning, Charles B. de; Singh, Moganavelli; Arbuthnot, Patrick; Ariatti, Mario

doi:10.1007/s00044-012-0252-2

Cited by 6 publications

(1 citation statement)

References 32 publications

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“…The complex formation with DNA of two nitrogen-pivoted aza-crown ethers linked to the cholesteryl-fused ring system N-(cholesteryloxycarbonyl)aza-15-crown-5 and N-(cholesteryloxycarbonyl)aza-18-crown-6incorporated to liposomes were observed in the human embryonic kidney cell line (HEK293). The increased transfection activity revealed stable DNA-protective lipoplexes containing aza-crown ethers, attributed to perturbations of the endosomes and the loosely packed cargo plasmid DNA [78].…”

Section: Transfection Activitymentioning

confidence: 99%

Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications

et al. 2022

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Cyclic organic compounds with several ether linkages in their structure are of much concern in our daily life applications. Crown ethers (CEs) are generally heterocyclic and extremely versatile compounds exhibiting higher binding affinity. In recent years, due to their unique structure, crown ethers are widely used in drug delivery, solvent extraction, cosmetics manufacturing, material studies, catalysis, separation, and organic synthesis. Beyond their conventional place in chemistry, this review article summarizes the synthesis, biological, and potential pharmacological activities of CEs. We have emphasized the prospects of CEs as anticancer, anti-inflammatory, antibacterial, and antifungal agents and have explored their amyloid genesis inhibitory activity, electrochemical, and potential metric sensing properties. The central feature of these compounds is their ability to form selective and stable complexes with various organic and inorganic cations. Therefore, CEs can be used in gas chromatography as the stationary phase and are also valuable for cation chromatographic to determine and separate alkali and alkaline-earth cations.

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Section: Transfection Activitymentioning

confidence: 99%