Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone

Bilski, Jan; Sarosiek, Jerzy; Murty, V.L.N.; Aono, Mitsuru; Moriga, Motoyuki; Slomiany, Amalia; Slomiany, Bronislaw L.

doi:10.1016/0006-2952(87)90562-4

Cited by 61 publications

(38 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Arakawa et al demonstrated the protective effect of TPA against gastric injury caused by ET in human subjects (9). Further, it has been reported that this effect of TPA may involve the metabolism of mucosal lipids (10)(11)(12).…”

Section: Discussionmentioning

confidence: 99%

Tetraprenylacetone promotes healing process of ethanol-induced gastric damage in the rat.

et al. 1991

View full text Add to dashboard Cite

ABSTRACT-Tetraprenylacetone (TPA: teprenon, geranylgeranylacetone) is a novel anti-ulcer agent developed in Japan. The aim of this study was to test whether TPA has the ability to promote the healing process of rat gastric mucosal injury induced by absolute ethanol (ET). Fasted rats received orally 5 ml/kg of absolute ET . Sixty minutes later, TPA (200 mg/kg) or saline (control) was administered intragastrically . Thereafter, the same dose of TPA or saline was given orally every 8 hours. To investigate the role of endogenous prostaglandins, indomethacin was given intraperitoneally every 8 hours. Twenty four or 48 hours after the first administration of TPA or saline, rats were sacrificed and the stomachs were removed. Administration of TPA significantly reduced lesion indices from 100 ± 12.9% (control) to 57.0 ± 12.8% (24 hours, P < 0.05) and from 100 ± 15.3% (control) to 17.6 ± 3.4% (48 hours, P < 0.01). Addition of indomethacin did not significantly affect this effect of TPA . Ultrastructual studies revealed that TPA stimulated regeneration of gastric mucosa damaged by ET after 24 and 48 hours. These results indicate that TPA has the ability to promote the healing process of gastric mucosal damage induced by absolute ET. It is, however, unlikely that endogenous prostaglandins are involved in this promotive effect of TPA on the healing process of gastric injury.

show abstract

Section: Discussionmentioning

confidence: 99%

Tetraprenylacetone promotes healing process of ethanol-induced gastric damage in the rat.

et al. 1991

View full text Add to dashboard Cite

show abstract

“…Analysis of Hsp70.1 mRNA Using Semi-quantitative Reverse Transcriptional-Polymerase Chain Reaction (RT-PCR) Total RNA from each tissue was extracted using a commercial kit, RNeasy ® Midi Kit (QIAGEN, GmbH, Hilden, Germany), according to the manufacturer's instructions. Reverse transcription was performed using the SUPER-SCRIPT TM First-Strand Synthesis System for RT-PCR (GIB-CO TM Invitrogen Corp., Carlsbad, CA, U.S.A.) with Oligo (dT) [12][13][14][15][16][17][18] primer.…”

Section: Methodsmentioning

confidence: 99%

“…This drug has a wide margin of safety and there is little information about any adverse drug actions. The antiulceric mechanism of GGA is believed to be due to the fact that this drug stimulates the synthesis and secretion of mucin, 13) thereby preventing degradation of gastric mucus exposed to several types of stress insults. Also, the gastric mucosa, liver, 14) small intestine 15) and heart 16) have been shown to be target organs for GGA cytoprotection.…”

mentioning

confidence: 99%

Reduction of the Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mice Using an Antiulcer Drug, Geranylgeranylacetone

Ishida

Oshimo

Nishimura

et al. 2004

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The protective effect of geranylgeranylacetone (GGA), an antiulcer drug, against the acute toxicity and teratogenicity produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in C57BL/6J mice. When mice were co-treated, GGA reduced the loss of body weight gain and lethality produced by TCDD but hepatomegaly and thymic atrophy were not improved. Additionally, no protective effect of GGA was observed in the formation of cleft palate and hydronephrosis in mouse fetuses caused by maternal exposure to TCDD. To clarify the reducing mechanism by GGA, the Hsp70.1 mRNA levels in liver and intestine were analyzed. However, it was difficult to explain the effect of GGA from the induction of Hsp70.1. GGA had also no effect on the induction of hepatic ethoxyresorufin O-deethylase activity by TCDD. These data suggest that GGA exhibits a protective effect against some forms of dioxin toxicity by a mechanism without involving inhibition of arylhydrocarbon receptor activation.

show abstract

“…10 The drug is now widely used in clinical practice in Japan, mainly for peptic ulcer patients. Tetraprenylacetone is known to stimulate synthesis and secretion of mucosal mucin 22,24 and gastric mucosal blood¯ow 15 as well as gastric mucosal hexosamine levels 10 and mucosal phospholipids. 14 It is also reported to suppress the decrease of transmural potential difference and lesion-enhancing factors under stress conditions.…”

Section: Discussionmentioning

confidence: 99%

Suppressive effect of tetraprenylacetone on gastric atrophy induced by short‐term administration of N‐methyl‐N^′‐nitro‐ N‐nitrosoguanidine in rats

Miwa

Nagahara

Wada

et al. 1997

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Background: Several studies have been reported on the effects of various therapeutic agents in enhancing or suppressing the carcinogenic activity of N‐methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG). However, it is still unknown whether a mucosal protective agent could suppress its carcinogenic activity. Methods: Twenty‐five Wistar male rats were divided into four groups: group 1, MNNG alone; group 2, MNNG + tetraprenylacetone; group 3, control; group 4, tetraprenylacetone alone. MNNG 100 mg/mL was freely given to groups 1 and 2, and tetraprenylacetone (200 mg/kg intraperitoneal) was additionally administered every other day to the rats in groups 2 and 4. The animals were sacrificed at 10 weeks and the gastric mucosa examined. Results: Atrophic changes were observed in the antrum after 8 weeks of oral administration of MNNG. Furthermore, using immunohistological analysis with 5‐bromo‐2′‐deoxyuridine (BrdU), the proliferative zone was found to be enlarged and shifted upward, although the BrdU labelling index of the proliferative zone was unaltered. Intraperitoneal administration of tetraprenylacetone every other day suppressed the MNNG‐induced atrophic change and the alterations proliferative markers. Tetraprenylacetone alone did not have an effect either on morphological or proliferative markers. Conclusion: These observations suggest that gastric mucosal defensive factors may play critical roles in suppressing atrophic change inducing carcinogenesis by an exogenic carcinogen.

show abstract

Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone

Cited by 61 publications

References 23 publications

Tetraprenylacetone promotes healing process of ethanol-induced gastric damage in the rat.

Tetraprenylacetone promotes healing process of ethanol-induced gastric damage in the rat.

Reduction of the Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mice Using an Antiulcer Drug, Geranylgeranylacetone

Suppressive effect of tetraprenylacetone on gastric atrophy induced by short‐term administration of N‐methyl‐N^′‐nitro‐ N‐nitrosoguanidine in rats

Contact Info

Product

Resources

About

Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone

Cited by 61 publications

References 23 publications

Tetraprenylacetone promotes healing process of ethanol-induced gastric damage in the rat.

Tetraprenylacetone promotes healing process of ethanol-induced gastric damage in the rat.

Reduction of the Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mice Using an Antiulcer Drug, Geranylgeranylacetone

Suppressive effect of tetraprenylacetone on gastric atrophy induced by short‐term administration of N‐methyl‐N′‐nitro‐ N‐nitrosoguanidine in rats

Contact Info

Product

Resources

About

Suppressive effect of tetraprenylacetone on gastric atrophy induced by short‐term administration of N‐methyl‐N^′‐nitro‐ N‐nitrosoguanidine in rats