Enhancement of the Antiemetic Action of Metoclopramide Against Cisplatin‐Induced Emesis by Transdermal Electrical Nerve Stimulation

Saller, Reinhard; Hellenbrecht, D.; Bühring, M.; Hess, H

doi:10.1002/j.1552-4604.1986.tb02918.x

Cited by 14 publications

(12 citation statements)

References 10 publications

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“…Studies have shown that TENS may exhibit such effects via augmenting the endorphines, encephalins, or both. This hypothesis has been supported by blocking the antiemetic effect of TENS by naloxone [6][7][8]. Saller et al [8] further proposed endogenous neuropeptides and serotoninergic mechanisms to be involved in the antiemetic effects of TENS because of their impact on gastrointestinal activity.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Transcutaneous electrical nerve stimulation in the prevention of postoperative nausea and vomiting after elective laparoscopic cholecystectomy

Çekmen

Salman

Keles

et al. 2007

Journal of Clinical Anesthesia

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Section: Discussionmentioning

confidence: 95%

“…Saller et al [8] used TENS together with metoclopramide in preventing cisplatin-related nausea and vomiting. They applied TENS at a frequency of 100 Hz, with a 10-mA current density.…”

Section: Discussionmentioning

confidence: 99%

Transcutaneous electrical nerve stimulation in the prevention of postoperative nausea and vomiting after elective laparoscopic cholecystectomy

Çekmen

Salman

Keles

et al. 2007

Journal of Clinical Anesthesia

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“…While acupressure alone produced little benefit in cisplatin-induced emesis, TENS was reported to have a synergistic action with antiemetic drugs such as metoclopramide and ondansetron in the prevention of emesis caused by cytotoxic drugs [12,18,22]. Saller et al [22] observed that TENS enhanced the antiemetic action of metoclopramide against cisplatininduced emesis in 10 of 11 treatment pairs that were studied. Similarly, McMillan et al [12] showed that 75% of the cases obtained some extra benefit from addition of TENS to ondansetron in a series of 16 patients receiving cytotoxic drugs.…”

Section: Discussionmentioning

confidence: 99%

Combination of Transcutaneous Electrical Nerve Stimulation and Ondansetron in Preventing Cisplatin-Induced Emesis

et al. 2001

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Objective: To find out whether the combination of transcutaneous electrical nerve stimulation (TENS) and ondansetron had an increased antiemetic effect. Materials and Methods: Fourteen testis and 11 bladder cancer patients were scheduled for 4 cycles of bleomycin-etoposide-cisplatin (BEP) or methotrexate-vinblastine-etoposide-cisplatin (MVEC) combination chemotherapy, respectively. At each cycle the whole cisplatin dose was given in 1 day that is 100 mg/m²/day in the BEP and 70 mg/m²/day in the MVEC protocols. Ondansetron was given at a dose of 12 mg/day and TENS was applied by commercially available ‘Relief Band’(Maven Labs, Inc., Citrus Heights, Calif., USA). The first 3 cycles of each case were blindly randomized to one of the following regimens; TENS vs. ondansetron vs. a combination of both. The regimens were applied during the administration of cisplatin and the patients were asked to report their nausea according to a scale between 0 to 10. Also for each regimen the number of emetic attacks experienced during the administration of cisplatin was recorded by the same observer. Then the scores of each regimen were compared. Results: The mean nausea scores for regimens TENS, ondansetron and TENS + ondansetron were found to be 5.12 ± 2.54, 3.0 ± 1.71 and 0.8 ± 0.96, respectively. Ondansetron was better than TENS in preventing nausea (p = 0.000). However the combination of TENS and ondansetron resulted in a significant decrease in nausea scores when compared to TENS alone (p = 0.000) or ondansetron alone (p = 0.000). The mean number of emetic attacks for the TENS, ondansetron and TENS + ondansetron regimens were 3.16 ± 1.84, 1.64 ± 1.44 and 0.56 ± 0.82, respectively. A statistically significant difference was present between the number of emetic attacks observed with the TENS + ondansetron combination and TENS alone (p = 0.000) or ondansetron alone (p = 0.001). Ondansetron was again better than TENS in preventing emetic attacks (p = 0.001). Conclusion: The use of TENS as an adjunct to ondansetron therapy has provided significant benefit in preventing nausea and emetic attacks caused by cisplatin.

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“…Transcutaneous electrical nerve stimulation (TENS) has also been shown to enhance the effect of antiemetic drugs, and its effects may be mediated by endogenous opioid peptides. 126 A meta-analysis of 19 randomized trials 127 found equivalent benefit of nonpharmacologic treatment of nausea in postsurgical patients compared to traditional therapy. This benefit was not found in children.…”

Section: Serotonin Antagonistsmentioning

confidence: 99%

Symptom Control in Palliative Care—Part I: Oncology as a Paradigmatic Example

Dalal

Fabbro

Bruera

2006

Journal of Palliative Medicine

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Achieving the best quality of life for patients and their families when a disease becomes progressive and no longer remains responsive to curative therapy is the primary goal of palliative care. A comprehensive care plan focusing on control of physical symptoms as well as psychological, social, and spiritual issues then becomes paramount in that context. Symptom assessment and treatment are a principle part of palliative care. This paper is the first of three in a series addressing non-pain symptoms, which are frequently encountered in the palliative care populations. The most frequent non-pain symptoms are constipation, chronic nausea and vomiting, anorexia, dyspnea, fatigue, and delirium. As symptoms are subjective, their expression varies from patient to patient, depending on the individual patient's perception and on other factors such as psychosocial issues. While symptoms are addressed individually, patients frequently have multiple coexisting symptoms. Generally told, once the intensity of a symptom has been assessed, it is necessary to assess the symptom in the context of other symptoms such as pain, appetite, fatigue, depression, and anxiety. Given that fact, adopting a multidimensional assessment allows for formulation of a more effective therapeutic strategy. More pertinently, this paper highlights the management of non-pain symptoms as an integral part of patient care and reviews the pathophysiologies, causes, assessment, and management of constipation, chronic nausea, and vomiting, each of which is common among the palliative care population. 391

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Enhancement of the Antiemetic Action of Metoclopramide Against Cisplatin‐Induced Emesis by Transdermal Electrical Nerve Stimulation

Cited by 14 publications

References 10 publications

Transcutaneous electrical nerve stimulation in the prevention of postoperative nausea and vomiting after elective laparoscopic cholecystectomy

Transcutaneous electrical nerve stimulation in the prevention of postoperative nausea and vomiting after elective laparoscopic cholecystectomy

Combination of Transcutaneous Electrical Nerve Stimulation and Ondansetron in Preventing Cisplatin-Induced Emesis

Symptom Control in Palliative Care—Part I: Oncology as a Paradigmatic Example

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