Abstract:The purpose of the study was to study the dynamics of foci of epileptic activity, which were reproduced in the cerebral cortex of kindled rats using the sodium salt of benzylpenicillin, under the conditions of individual and combined use of pioglitazone and thioperamid. Under conditions of acute observation in rats kindled with pentylenetetrazole repeated administration (30-35 mg/kg, i.p.), the influence of thioperamid (2,5 and 15,0 mg/kg, i.p.) and pioglitazone(50,0 and 200,0 mg/kg, i.p.) administrations upon… Show more
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