Enhancement of the antibiotic activity mediated by the essential oil of Ocotea odorifera (VELL) ROWHER and safrole association

Almeida, Ray Silva de; Ribeiro-Filho, Jaime; Freitas, Priscilla Ramos; Araújo, Ana Carolina Justino de; Santos, Eduardo L.; Tintino, Saulo Relison; Moura, T.F.A.L.; Ferreira, Vitória Assunção; Ferreira, Beatriz Assunção; Fonseca, Victor Juno Alencar; Leite, Pedro Ivo Palacio; Silva, Ana Cristina Albuquerque da; Silva, Luiz Everson da; Amaral, Wanderlei do; Deschamps, Cícero; Siyadatpanah, Abolghasem; Wilairatana, Polrat; Coutinho, Henrique Douglas Melo

doi:10.1016/j.jiph.2021.09.028

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…For methicillin-resistant S. aureus (MRSA), Rivas da Silva et al (2012) showed MIC 4.150 μg/mL for α-pinene and 6.250 μg/mL for β-pinene MIC. De Almeida et al (2022) demonstrated that safrole, another compound contained in DW_EO, exhibits antibacterial activity against clinical strains of S. aureus .…”

Section: Biology Activitymentioning

confidence: 99%

“…Likewise, it has been shown that DW_EO compounds present synergy with conventionally used antimicrobials. De Almeida et al (2022) explained that safrole presents a synergistic effect with gentamicin, improving its efficacy against S. aureus , which promises to be useful in the development of therapeutic tools to combat bacterial resistance to aminoglycosides. Hu et al (2020) mentioned that linalool could increase the susceptibility of bacterial strains in combination with classical antimicrobial agents or other natural antibacterial agents.…”

Section: Biology Activitymentioning

confidence: 99%

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Biological activity of the essential oil of Drimys winteri

Navarro,

Urrejola,

Espinoza

et al. 2024

Front. Chem.

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In the Chilean indigenous culture, the tree Drimys winteri (Winteraceae) Canelo is of great importance and is considered the sacred Mapuche tree. It has antibacterial and disinfectant properties and is used in the treatment of various diseases, such as fevers, ulcers, cancers, and respiratory tract problems. The essential oil obtained from D. winteri, DW_EO, is bioactive, possesses insecticidal and repellent properties against pests, and shows activity toward plant growth regulators. It also has a phytotoxic effect against the growth and germination of weeds. The essential oil obtained from the leaves and bark of Drimys winteri has demonstrated antifungal, immunomodulatory, anti-inflammatory, and anticancer properties in in vitro and in vivo studies. It also possesses antioxidant activity and antibacterial effects. The essential oil contains monoterpenes such as zafrol, pinenes, and linalool, among others, that contribute to its bioactivity. The DW_EO and bioactive compounds have great potential in various applications in medicine, industrial food, sanitizer, and other areas.

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Section: Biology Activitymentioning

confidence: 99%

Section: Biology Activitymentioning

confidence: 99%

Biological activity of the essential oil of Drimys winteri

Navarro,

Urrejola,

Espinoza

et al. 2024

Front. Chem.

View full text Add to dashboard Cite

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Antimicrobial resistance expansion in pathogens: a review of current mitigation strategies and advances towards innovative therapy

Adefisoye,

Olaniran

2023

JAC-Antimicrobial Resistance

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The escalating problem of antimicrobial resistance (AMR) proliferation in clinically important pathogens has become one of the biggest threats to human health and the global economy. Previous studies have estimated AMR-associated deaths and disability-adjusted life-years (DALYs) in many countries with a view to presenting a clearer picture of the global burden of AMR-related diseases. Recently, several novel strategies have been advanced to combat resistance spread. These include efflux activity inhibition, closing of mutant selection window (MSW), biofilm disruption, lytic bacteriophage particles, nanoantibiotics, engineered antimicrobial peptides, and the CRISPR-Cas9 gene-editing technique. The single or integrated deployment of these strategies has shown potentialities towards mitigating resistance and contributing to valuable therapeutic outcomes. Correspondingly, the new paradigm of personalized medicine demands innovative interventions such as improved and accurate point-of-care diagnosis and treatment to curtail AMR. The CRISPR-Cas system is a novel and highly promising nucleic acid detection and manipulating technology with the potential for application in the control of AMR. This review thus considers the specifics of some of the AMR-mitigating strategies, while noting their drawbacks, and discusses the advances in the CRISPR-based technology as an important point-of-care tool for tracking and curbing AMR in our fight against a looming ‘post-antibiotic’ era.

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Enhancement of the antibiotic activity mediated by the essential oil of Ocotea odorifera (VELL) ROWHER and safrole association

Cited by 2 publications

References 34 publications

Biological activity of the essential oil of Drimys winteri

Biological activity of the essential oil of Drimys winteri

Antimicrobial resistance expansion in pathogens: a review of current mitigation strategies and advances towards innovative therapy

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