Enhancement of the adhesive strength of antithrombogenic and hemocompatible a-C:H:SiOx films to polypropylene

Grenadyorov, A. S.; Solovyev, A. A.; Иванова, Н. М.; Zhulkov, М. О.; Chernyavskiy, Alexander; Малащенко, В. В.; Хлусов, И. А.

doi:10.1016/j.surfcoat.2020.126132

Cited by 9 publications

(9 citation statements)

References 57 publications

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“…Recent reports indicated that plasma-surface-engineered PP with various optimized process variables [ 255 ] has improved surface hydrophilicity and adhesive properties of PP or poly(ethylebe terephthalate) (PET) [ 256 , 257 ]. Grenadyorov et al reported that the plasma-assisted deposition of silicon and oxy functionalities incorporated with hydrogenated amorphous carbon films onto PP improved the antithrombogenicity and hemocompatibility [ 258 ]. Blood compatibility with the deposited film was evaluated by an in vitro investigation of platelet adhesion and cytotoxicity.…”

Section: Applicationsmentioning

confidence: 99%

Plasma Surface Engineering of Natural and Sustainable Polymeric Derivatives and Their Potential Applications

Pillai

Thomas

2023

Polymers

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Recently, natural as well as synthetic polymers have been receiving significant attention as candidates to replace non-renewable materials. With the exponential developments in the world each day, the collateral damage to the environment is incessant. Increased demands for reducing pollution and energy consumption are the driving force behind the research related to surface-modified natural fibers (NFs), polymers, and various derivatives of them such as natural-fiber-reinforced polymer composites. Natural fibers have received special attention for industrial applications due to their favorable characteristics, such as low cost, abundance, light weight, and biodegradable nature. Even though NFs offer many potential applications, they still face some challenges in terms of durability, strength, and processing. Many of these have been addressed by various surface modification methodologies and compositing with polymers. Among different surface treatment strategies, low-temperature plasma (LTP) surface treatment has recently received special attention for tailoring surface properties of different materials, including NFs and synthetic polymers, without affecting any of the bulk properties of these materials. Hence, it is very important to get an overview of the latest developments in this field. The present article attempts to give an overview of different materials such as NFs, synthetic polymers, and composites. Special attention was placed on the low-temperature plasma-based surface engineering of these materials for diverse applications, which include but are not limited to environmental remediation, packaging, biomedical devices, and sensor development.

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Section: Applicationsmentioning

confidence: 99%

Plasma Surface Engineering of Natural and Sustainable Polymeric Derivatives and Their Potential Applications

Pillai

Thomas

2023

Polymers

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“…In this case, in addition to drug therapy, the problem of prevention of thromboembolic complications can be solved with the development of hypothrombogenic coatings, which hinder active cell adhesion and migration. The developed a-C:H:SiO x coating significantly decreases in vitro platelet adhesion [ 22 , 23 ]. The evident benefit of such a coating applied to cardiovascular implants will have a prolonged antiproliferative effect in relation to endothelial cells.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Cell Behavior and Nitric Oxide Production on a-C:H:SiOx-Coated Ti-6Al-4V Substrate

Хлусов

Grenadyorov

Solovyev

et al. 2023

IJMS

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This paper focuses on the surface modification of the Ti-6Al-4V alloy substrate via a-C:H:SiOx coating deposition. Research results concern the a-C:H:SiOx coating structure, investigated using transmission electron microscopy and in vitro endothelization to study the coating. Based on the analysis of the atomic radial distribution function, a model is proposed for the atomic short-range order structure of the a-C:H:SiOx coating, and chemical bonds (C–O, C–C, Si–C, Si–O, and Si–Si) are identified. It is shown that the a-C:H:SiOx coating does not possess prolonged cytotoxicity in relation to EA.hy926 endothelial cells. In vitro investigations showed that the adhesion, cell number, and nitric oxide production by EA.hy926 endothelial cells on the a-C:H:SiOx-coated Ti-6Al-4V substrate are significantly lower than those on the uncoated surface. The findings suggest that the a-C:H:SiOx coating can reduce the risk of endothelial cell hyperproliferation on implants and medical devices, including mechanical prosthetic heart valves, endovascular stents, and mechanical circulatory support devices.

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“…In Ref. 20, the a‐C:H:SiO x film deposited onto polypropylene provided low thrombogenicity and no cytotoxic activity toward human leukocytes. According to, 21 the a‐C:H:SiO x film improved the corrosion resistance of the Ti–6Al–4V alloy surface to 0.5 M NaCl solution and phosphate‐buffered saline.…”

Section: Introductionmentioning

confidence: 99%

Morphofunctional reaction of leukocytes and platelets in in vitro contact with a‐C:H:SiO_x‐coated Ti–6Al–4V substrate

Grenadyorov

Solovyev

Оскомов

et al. 2022

J Biomedical Materials Res

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The article deals with the plasma‐assisted chemical vapor deposition of 0.3–1.4 μm thick a‐C:H:SiOx films in a mixture of argon and polyphenylmethylsiloxane vapor onto the Ti–6Al–4V alloy substrate, which is often used as an implant material. The a‐C:H:SiOx film structure is studied by the Fourier‐transform infrared and Raman spectroscopies. The pull‐off adhesion test assesses the adhesive strength of a‐C:H:SiOx films, and the ball‐on‐disk method is employed to measure their wear rate and friction coefficient. According to these studies, a‐C:H:SiOx films are highly adhesive to the Ti–6Al–4V substrate, have low (0.056) friction coefficient and wear rate (9.8 × 10−8 mm3 N−1 m−1) in phosphate‐buffered saline at 40°C. In vitro studies show neither thrombogenicity nor cytotoxicity of the a‐C:H:SiOx film for the human blood mononuclear cells (hBMNCs). The in vitro contact between the hBMNC culture and a‐C:H:SiOx films 0.8–1.4 μm thick deposited onto Ti–6Al–4V substrates reduces a 24‐hour secretion of pro‐inflammatory cytokines and chemokines IL‐8, IL‐17, TNFα, RANTES, and MCP‐1. This reduction is more significant when the film thickness is 1.4 μm and implies its potential anti‐inflammatory effect and possible application in cardiovascular surgery. The dependence is suggested for the concentration of anti‐inflammatory cytokines and chemokines and the a‐C:H:SiOx film thickness, which correlates with the surface wettability and electrostatic potential. The article discusses the possible applications of the anti‐inflammatory effect and low thrombogenicity of a‐C:H:SiOx films in cardiovascular surgery.

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Enhancement of the adhesive strength of antithrombogenic and hemocompatible a-C:H:SiOx films to polypropylene

Cited by 9 publications

References 57 publications

Plasma Surface Engineering of Natural and Sustainable Polymeric Derivatives and Their Potential Applications

Plasma Surface Engineering of Natural and Sustainable Polymeric Derivatives and Their Potential Applications

Endothelial Cell Behavior and Nitric Oxide Production on a-C:H:SiOx-Coated Ti-6Al-4V Substrate

Morphofunctional reaction of leukocytes and platelets in in vitro contact with a‐C:H:SiO_x‐coated Ti–6Al–4V substrate

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Enhancement of the adhesive strength of antithrombogenic and hemocompatible a-C:H:SiOx films to polypropylene

Cited by 9 publications

References 57 publications

Plasma Surface Engineering of Natural and Sustainable Polymeric Derivatives and Their Potential Applications

Plasma Surface Engineering of Natural and Sustainable Polymeric Derivatives and Their Potential Applications

Endothelial Cell Behavior and Nitric Oxide Production on a-C:H:SiOx-Coated Ti-6Al-4V Substrate

Morphofunctional reaction of leukocytes and platelets in in vitro contact with a‐C:H:SiOx‐coated Ti–6Al–4V substrate

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Product

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Morphofunctional reaction of leukocytes and platelets in in vitro contact with a‐C:H:SiO_x‐coated Ti–6Al–4V substrate