Enhancement of some 5-HT-dependent behavioural responses following repeated immobilization in rats

Kennett, Guy A.; Dickinson, S.L.; Curzon, G.

doi:10.1016/0006-8993(85)90684-5

Cited by 252 publications

(79 citation statements)

References 49 publications

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“…The open field test (OFT) evaluated the general locomotor and exploratory behavior of rats and the experiments were performed as described previously (Kennett et al, 1985). Each rat was placed at the centre of the open field (80 cm square chamber, 40 cm high walls, light of 80 lux with its floor divided into 25 equal squares) for 3 min in a quiet room after being weighed.…”

Section: Open Field Testmentioning

confidence: 99%

Antidepressant effects of the extract YZ-50 fromPolygala tenuifoliain chronic mild stress treated rats and its possible mechanisms

Liu

Guo

et al. 2010

Pharmaceutical Biology

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Section: Open Field Testmentioning

confidence: 99%

Antidepressant effects of the extract YZ-50 fromPolygala tenuifoliain chronic mild stress treated rats and its possible mechanisms

Liu

Guo

et al. 2010

Pharmaceutical Biology

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“…The open field test evaluated the general locomotor and exploratory behavior of rats and the experiments were performed as described previously [36]. Each rat was placed at the centre of the open field (76 cm square chamber, 40-cm-high walls, light of 80 lux.…”

Section: Open Field Test (Oft)mentioning

confidence: 99%

Beneficial effects of exercise and its molecular mechanisms on depression in rats

Zheng

Liu

et al. 2006

Behavioural Brain Research

186

129

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Exercise showed the beneficial effects on mental health in depressed sufferers, whereas, its underlying mechanisms remained unresolved. This study utilized the chronic unpredictable stress (CNS) animal model of depression to evaluate the effects of exercise on depressive behaviors and spatial performance in rats. Furthermore, we tested the hypothesis that the capacity of exercise to reverse the harmful effects of CNS was relative to the hypothalamo-pituitary-adrenal (HPA) system and brain-derived neurotrophic factor (BDNF) in the hippocampus. Animal groups were exposed to CNS for 4 weeks with and without access to voluntary wheel running. Stressed rats consumed significantly less of a 1% sucrose solution during CNS and exhibited a significant decrease in open field behavior. On the other hand, they showed impaired spatial performance in Morris water maze test 2 weeks after the end of CNS. Further, CNS significantly decreased hippocampal BDNF mRNA levels. However, voluntary exercise improved or even reversed these harmful behavioral effects in stressed rats. Furthermore, exercise counteracted a decrease in hippocampal BDNF mRNA caused by CNS. In addition, we also found that CMS alone increased circulating corticosterone (CORT) significantly and decreased hippocampal glucocorticoid receptor (GR) mRNA. At the same time, exercise alone increased CORT moderately and did not affect hippocampal GR mRNA levels. While, when both CNS and exercise were combined, exercise reduced the increase of CORT and the decrease of GR caused by CMS.The results demonstrated that: (1) exercise reversed the harmful effects of CNS on mood and spatial performance in rats and (2) the behavioral changes induced by exercise and/or CNS might be associated with hippocampal BDNF levels, and in addition, the HPA system might play different roles in the two different processes.

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“…Further, it is well known that the recurrence phenomenon is also caused by stress. Several studies have shown that previous exposure to stress results in an increased passive behavioural response when the subject is subsequently confronted with a novel stressful situation (Anisman et al, 1978;Katz et al, 1981;Kennett et al, 1985;Cancela et al, 1991;Murua & Molina, 1991;Molina et al, 1994 test and reduced activity in response to a novel environment (Weiss et al, 1981;Plaznik et al, 1988;Van Dijken et al, 1992). The conditioned emotional response can be measured in terms of inhibition of locomotor activity and the inhibition of lever pressing behaviour for a food or water reward produced by stimuli previously paired with stress (Brady, 1956;Hunt, 1961).…”

Section: Effects Of Antipsychotics On the Pcp-induced Enhancement Of mentioning

confidence: 99%

Enhancement of immobility in a forced swimming test by subacute or repeated treatment with phencyclidine: a new model of schizophrenia

Noda

Yamada

Furukawa

et al. 1995

British J Pharmacology

210

124

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1 Immobility induced by forced swimming is well known as an animal model of depression. To develop an animal model for the negative symptoms of schizophrenia, in particular the depressive symptoms, the effect of phencyclidine (PCP) on immobility in the forced swimming test was investigated in mice, since PCP produces such negative symptoms in humans.2 Repeated treatment with PCP (10 mg kg-' day-', s.c., once a day for 14 days) prolonged the immobility time in the forced swimming test 24 h after the final injection compared with saline treatment; the effect was not obtained by single or 5 treatments with PCP (10 mg kg-', s.c.), or by repeated treatment with methamphetamine (0.5 and 1 mg kg-' day-', s.c., once a day for 14 days). 3 The enhancing effect of PCP (10 mg kg-' day-', s.c.) on the immobility persisted for at least 21 days after the withdrawal of the drug. 5 The enhancing effect of PCP on the immobility was attenuated by ritanserin (3 and 10 mg kg-', p.o.), risperidone (0.3 mg kg-', p.o.), and clozapine (3 and 10 mg kg-', p.o.), whereas haloperidol (0.3 and 1 mg kg-', p.o.) had no effect. 6 These results suggest that the enhancement of immobility in the forced swimming test brought about by repeated PCP treatment could be used as a model of the negative symptoms, particularly the depression, of schizophrenia. This effect of PCP appeared to be mediated, at least in part, via 5-HT2A receptors.

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Enhancement of some 5-HT-dependent behavioural responses following repeated immobilization in rats

Cited by 252 publications

References 49 publications

Antidepressant effects of the extract YZ-50 fromPolygala tenuifoliain chronic mild stress treated rats and its possible mechanisms

Antidepressant effects of the extract YZ-50 fromPolygala tenuifoliain chronic mild stress treated rats and its possible mechanisms

Beneficial effects of exercise and its molecular mechanisms on depression in rats

Enhancement of immobility in a forced swimming test by subacute or repeated treatment with phencyclidine: a new model of schizophrenia

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