Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency

Takeda, Atsüshi; Tamano, Haruna; Kan, Fumika; Hanajima, Tomoyuki; Yamada, Kohei; Oku, Naoto

doi:10.1016/j.lfs.2008.02.005

Cited by 39 publications

(29 citation statements)

References 37 publications

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“…It is interesting to note that a zinc-deficient diet given to young adult rats produced an impairment in learning and memory, and this could be reversed by feeding with a normal diet [52], while such impairments caused by diet administration during development are irreversible [52, 53]. Other effects reported to be induced by zinc deficiency include a decrease in the number of progenitor cells and immature neurons in the rodent hippocampus, indicating disrupted neurogenesis and synaptogenesis [55–58]. …”

Section: Deficiency Of Zinc In Depressionmentioning

confidence: 99%

Biological consequences of zinc deficiency in the pathomechanisms of selected diseases

et al. 2014

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From many points of view, zinc is one of the most important trace elements in biological systems. Many articles describe the well-known role of this metal in human physiology and pathophysiology, but in the related literature, there is a lack of current and reliable reviews of the role of zinc deficiency in many diseases. In this article, we describe the role of zinc deficiency in the oxidative stress control, immune response, proliferation, and pathogenesis and pathophysiology of selected diseases such as depression, cardiovascular diseases, diabetes mellitus, Alzheimer’s disease, and Wilson’s disease.

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Section: Deficiency Of Zinc In Depressionmentioning

confidence: 99%

Biological consequences of zinc deficiency in the pathomechanisms of selected diseases

et al. 2014

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“…Previous studies using mice have reported that SI enhanced the aggressive behavior caused by ZD [43]. Considering the changes observed in the behavioral experiments from a clinical point of view, decreased anxiety or enhanced aggressive behavior is often observed in subjects a manic state.…”

Section: Discussionmentioning

confidence: 97%

The co-occurrence of zinc deficiency and social isolation has the opposite effects on mood compared with either condition alone due to changes in the central norepinephrine system

Mitsuya

Omata

Kiyono

et al. 2015

Behavioural Brain Research

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Nutritional and social environmental problems during the early stages of life are closely associated with the pathophysiology of mood disorders such as depression. Disruption or dysfunction of the central norepinephrine (NE) system is also considered to play a role in mood disorders. Therefore, we evaluated the effects of zinc deficiency and/or social isolation on mood and changes in the central NE system using rats. Compared with the controls, the rats subjected to zinc deficiency or social isolation alone exhibited increased anxiety-related behavior in the elevated plus maze and greater depression-like behavior in the forced swim test. However, the co-occurrence of zinc deficiency and social isolation resulted in decreased anxiety-related behavior and control levels of depression-like behavior. Social isolation alone decreased the rats' cerebral NE concentrations. The expression of the NE transporter was not affected by social isolation alone, but its expression in the locus coeruleus was markedly decreased by the co-occurrence of social isolation and zinc deficiency, and this change was accompanied by an increase in the blood concentration of 3-methoxy-4-hydroxyphenylglycol, which is a marker of central NE system activity. These findings suggest that zinc deficiency or social isolation alone induce anxious or depressive symptoms, but the presence of both conditions has anxiolytic or antidepressive effects. Furthermore, these opposing effects of mood-related behaviors were found to be associated with changes in the central NE system.

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“…Dietary zinc deficiency increases serum corticosterone level in mice and rats while decreases serum zinc level [109,110] (Fig. 3).…”

Section: Zinc Deficiency and Depressionmentioning

confidence: 91%

“…The increase in depression-like behavior is reported in zinc-deficient mice [111] and rats [112], and is observed in no appreciable decrease in zinc concentration in the brain [113]. Neuropsychological symptoms are caused prior to the decreases in histochemically reactive zinc and/or extracellular zinc in the brain, which are responsive to zinc deficiency [109,110,114,115]. Thus, abnormal corticosterone secretion induced by dietary zinc deficiency may be critical for neuropsychological symptoms such as depression (Fig.…”

Section: Zinc Deficiency and Depressionmentioning

confidence: 99%

Zinc Signaling in the Hippocampus and Its Relation to Pathogenesis of Depression

Takeda

2010

Mol Neurobiol

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Zinc is released from glutamatergic (zincergic) neuron terminals in the brain, followed by the increase in Zn²⁺ concentration in the intracellular (cytosol) compartment as well as that in the extracellular compartment. Intracellular Zn²⁺ concentration mainly increases through calcium-permeable channels and serves as Zn²⁺ signal as well as extracellular Zn²⁺ concentration. Hippocampal Zn²⁺ signaling may participate in synaptic plasticity such as long-term potentiation and cognitive function. On the other hand, subclinical zinc deficiency is common in the old who might be more susceptible to depression. Zinc deficiency causes abnormal glucocorticoid secretion and increases depression-like behavior in animals. Neuropsychological symptoms are observed prior to the decrease in Zn²⁺ signal in the hippocampus under zinc deficiency. This paper summarizes that hippocampal Zn²⁺ signaling serves to maintain healthy brain and that glucocorticoid signaling, which is responsive to zinc homeostasis in the living body, is linked to the pathophysiology of depression.

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Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency

Cited by 39 publications

References 37 publications

Biological consequences of zinc deficiency in the pathomechanisms of selected diseases

Biological consequences of zinc deficiency in the pathomechanisms of selected diseases

The co-occurrence of zinc deficiency and social isolation has the opposite effects on mood compared with either condition alone due to changes in the central norepinephrine system

Zinc Signaling in the Hippocampus and Its Relation to Pathogenesis of Depression

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