Enhancement of skin permeation and anti-inflammatory effect of indomethacin using microemulsion

Barakat, Nahla S.; El-Medany, Azza; Fouad, Ehab A.

doi:10.4103/0973-8398.91989

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…Skin permeation enhancement by microemulsions has been widely studied for several anti-inflammatory drugs, for example, indomethacin, aspirin, and rofecoxib [ 82 – 84 ]. Microemulsification of babassu oil seems to enhance skin permeation of anti-inflammatory active compounds found in the oil, reaching the same percentages of edema inhibition as pure babassu oil with a much lower oil concentration.…”

Section: Resultsmentioning

confidence: 99%

Anti‐Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery

Reis

Santos

Silva

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Babassu oil extraction is the main income source in nut breakers communities in northeast of Brazil. Among these communities, babassu oil is used for cooking but also medically to treat skin wounds and inflammation, and vulvovaginitis. This study aimed to evaluate the anti-inflammatory activity of babassu oil and develop a microemulsion system with babassu oil for topical delivery. Topical anti-inflammatory activity was evaluated in mice ear edema using PMA, arachidonic acid, ethyl phenylpropiolate, phenol, and capsaicin as phlogistic agents. A microemulsion system was successfully developed using a Span® 80/Kolliphor® EL ratio of 6 : 4 as the surfactant system (S), propylene glycol and water (3 : 1) as the aqueous phase (A), and babassu oil as the oil phase (O), and analyzed through conductivity, SAXS, DSC, TEM, and rheological assays. Babassu oil and lauric acid showed anti-inflammatory activity in mice ear edema, through inhibition of eicosanoid pathway and bioactive amines. The developed formulation (39% A, 12.2% O, and 48.8% S) was classified as a bicontinuous to o/w transition microemulsion that showed a Newtonian profile. The topical anti-inflammatory activity of microemulsified babassu oil was markedly increased. A new delivery system of babassu microemulsion droplet clusters was designed to enhance the therapeutic efficacy of vegetable oil.

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Section: Resultsmentioning

confidence: 99%

Anti‐Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery

Reis

Santos

Silva

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…The largest region of microemulsion was checked using pseudo ternary phase diagrams as given in figure 2 13,14 .…”

Section: Preparation Of Microemulsions By Construction Of Pseudo-ternmentioning

confidence: 99%

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2014

IJPSR

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Background: Neuropathic pain is a type of chronic pain that occurs when nerves in the central nervous system become injured or damaged. Currently only a limited number of topical treatments are available to treat it. Hence an attempt was made to alleviate symptoms of neuropathic pain by topical application of a local anaesthetic drug. Results: Microemulsions were formulated using Oleic acid as the oily phase and Tween 80 and ethanol in 1:1 ratio as the surfactant and cosurfactant respectively. The microemulsions thus formed were clear, transparent and aesthetic in appearance and showed low viscosity and near neutral pH. They exhibited electrical conductivity indicating they were o/w microemulsions. The particle size was in the submicron range while the polydispersity index was 0.4 indicating a uniform particle size distribution. A satisfactory and elegant gel was obtained using Xanthan gum as the gelling agent. In-vitro and ex-vivo drug diffusion indicated a sustained release of the drug over 8 hours.

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“…Microemulsion (ME) is defined as an O/W or W/O emulsion having a droplet size from 10 to 100nm and does not have the tendency to coalesce 1 . MEs are composed of oil phase, surfactant, cosurfactant and aqueous phase at appropriate ratios.…”

Section: Introductionmentioning

confidence: 99%

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2016

IJPSR

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ABSTRACT:The objective of the present research work was to conduct in vivo pharmacokinetic study of microemulsion based transdermal gel of glimepiride for evaluating the enhanced bioavailability. Saturation solubility studies of the drug were conducted in various solvents and oils. Labrafil M 1944 CS, Tween 80 and Transcutol P were used as oil phase, surfactant and cosurfactants respectively for the preparation of microemulsion based on the results from solubility studies. Surfactant to cosurfactant ratio was fixed as 1:2 in all the formulations. Microemulsion based gel was prepared using carbopol 934 as gelling agent and oil to s mix ratio of 1:9. In vivo pharmacokinetic studies conducted in rabbits revealed that the bioavailability of microemulsion based gel was increased 5.4 times compared to oral suspension demonstrating avoidance of first pass metabolism and oral degradation. This indicates the effective management of plasma profile of glimepiride when it is administered as microemulsion based gel through transdermal route.

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Enhancement of skin permeation and anti-inflammatory effect of indomethacin using microemulsion

Cited by 8 publications

References 39 publications

Anti‐Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery

Anti‐Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery

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