Enhancement of scaffolding properties for poly(3-hydroxybutyrate): blending with poly-β-alanine and wet electrospinning

Çatıker, Efkan; Tokak, Elvan Konuk; Gültan, Tuğçe; Gümüşderelı́oğlu, Menemşe

doi:10.1080/00914037.2018.1552862

Cited by 8 publications

(3 citation statements)

References 40 publications

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“…Regarding the composition of the systems, it was observed that the composition does not exert a statistically significant influence on the cytocompatibility of the systems. The obtained results are congruent with the literature since other authors have already evaluated the cytotoxicity of PHB and PCL and proved the biocompatible character of these matrices both for the L919 [80][81][82] and the MC3T3-E1 lineage. [83][84][85][86] 4 | CONCLUSIONS PHB/PCL blends with different molar masses processed in a mixing chamber and compression molded were obtained successfully.…”

Section: Cellular Viabilitysupporting

confidence: 91%

Effects of polycaprolactone viscosity on morphology, mechanical properties, water uptake, and cellular viability in poly(3‐hydroxybutyrate)/polycaprolactone blends for tissue engineering

Cavalcante,

de Menezes

2023

Polymers for Advanced Techs

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In this study, two polycaprolactones (PCLs) with different molar masses were evaluated regarding their influence on the melt processability, morphology viscoelastic and mechanical properties, water uptake, and fibroblast and pre‐osteoblast viability of poly(3‐hydroxybutyrate)/polycaprolactone (PHB/PCL) blends. PHB/PCL blends were prepared in a mixing chamber following 90/10 and 70/30 ratios and later compression molded. The torque rheometry results show that the blends' processability is influenced by the ratio and molar mass of the PCL used in its obtaining, those being more strongly affected by the PCL with lower molar mass. The results indicate that the polymeric blend was immiscible in any proportion and molar mass of PCL used. The blends showed a sea‐island morphology in which the diameter of the dispersed phase depended on the composition. In general, even though the molar mass of PCL differed, the blends showed similar behaviors. However, a great difference was observed in the fracture mechanism for the blend with PCL of lower molar mass, which did not present the ability to fibrillate before rupture, due to its low mechanical resistance. The blends showed greater water uptake capabilities when compared to the pure polymers due to the diffusion of water through the gaps in between the phases. The blends showed high cell viability when tested in fibroblast cells of the L929 lineage and pre‐osteoblast cells of the MCT3‐E1 lineage, indicating that these materials are promising for application in bone tissue engineering.

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Section: Cellular Viabilitysupporting

confidence: 91%

Effects of polycaprolactone viscosity on morphology, mechanical properties, water uptake, and cellular viability in poly(3‐hydroxybutyrate)/polycaprolactone blends for tissue engineering

Cavalcante,

de Menezes

2023

Polymers for Advanced Techs

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“…As shown in Figure a, polyethylenimine (PEI) showed high cytotoxicity, with only 69.8% to 42.3% cell viability at concentrations ranging from 18 to 200 μg/mL. However, S 3 showed very good biocompatibility because 125.6% cell viability was observed at a concentration of 18 μg/mL, which should be attributed the unique structure of β-alanine segments in polymer. − With increasing concentrations of S 3 , the cell viability decreased slightly, and there was still 102.5% cell viability at 200 μg/mL. Next, the cell toxicities of the resulting samples were also studied by analyzing the cellular uptake of doxorubicin (DOX)-loaded S 3 by HSF cells at an equivalent concentration of 0.49 μg/mL DOX.…”

Section: Resultsmentioning

confidence: 99%

Preparing Degradable Polymers with Promising Mechanical Properties by Hydrogen Transfer Polymerization

et al. 2022

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Hydrogen transfer polymerization (HTP) of vinyl monomers with active protons has resulted in heterochain polymers with attractive biodegradability and biocompatibility, which should enable it to be one of the most promising synthetic techniques. However, the molecular weight of the resultant polymers from HTP has been shown to be rather low, such that the products have nearly no practical application. The present work focuses on employing HTP to synthesize high-molecular-weight polymers and preparing biomaterials with good mechanical properties. Detailed investigations into the polymerization process suggested that introducing a small amount of diolefin and catalyst at the last stage of HTP of 2-hydroxyethyl acrylate (HEA) could result in a polymer with a weight-average molecular weight up to 355.8 kg/mol. During this process, diolefin worked as a coupling agent, which could both react with hydroxyl groups by oxa-Michael addition and combine with double bonds through Rauhut–Currier (RC) reactions. The resultant polymer exhibited abundant vinyl bonds existing both in the middle and at the termini and hence can be directly used as a macromonomer for biodegradable materials after UV curing with microfluidic spinning. On the basis of this strategy, the copolymerization of HEA and acrylamide (Am) was conducted, and the maximum tensile strength of the product reached as high as 30 MPa with an elongation percentage of 27.8%. What is more, the corresponding materials not only showed very good degradability but also had nearly no cell toxicity, instead helping to enhance cell viability.

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“…Because PBA has a highly crystalline polymer structure, it is excellent in terms of heat resistance and mechanical properties, so it has excellent results in biomedical applications, is biologically active, and supports cell adhesion [ 126 ]. Catiker et al [ 127 ] blended PBA with an optically active, biocompatible biodegradable thermoplastic poly(3-hydroxybutyrate) (P3HB). The addition of PBA enhances the opening of functional groups on the surface of P3HB and increases the biocompatibility and scaffolding properties of P3HB.…”

Section: Amino Acidmentioning

confidence: 99%

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

Song

et al. 2022

Biomolecules

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The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis.

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Enhancement of scaffolding properties for poly(3-hydroxybutyrate): blending with poly-β-alanine and wet electrospinning

Cited by 8 publications

References 40 publications

Effects of polycaprolactone viscosity on morphology, mechanical properties, water uptake, and cellular viability in poly(3‐hydroxybutyrate)/polycaprolactone blends for tissue engineering

Effects of polycaprolactone viscosity on morphology, mechanical properties, water uptake, and cellular viability in poly(3‐hydroxybutyrate)/polycaprolactone blends for tissue engineering

Preparing Degradable Polymers with Promising Mechanical Properties by Hydrogen Transfer Polymerization

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

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