Enhancement of Propylene Glycol Distribution in the Skin by High Purity cis-Unsaturated Fatty Acids with Different Alkyl Chain Lengths Having Different Double Bond Position.

Enhanced transdermal delivery of loratadine from the EVA matrix

“…Fatty acids can have a variety of chain lengths, double bonds characteristics (position, number, and configuration), branching schema, and substituents. These structural variations can affect their suitability as skin penetration enhancers (18)(19)(20)(21). Fatty acids can insert between the hydrophobic tails of the stratum corneum lipid bilayer, disturbing their packing, increasing their fluidity, and subsequently, decreasing the diffusional resistance to permeants (22).…”

Skin Permeation Enhancement of Diclofenac by Fatty Acids

“…Fatty acids are known to enter the hydrophobic tails of the stratum corneum lipid bilayer, disturbing their packing, increasing their fluidity, and subsequently, decreasing the diffusional resistance to permeates (Golden et al 1987). The effect of varying carbon-chain lengths, degrees and types of unsaturation (position, number), the branching schema, and substituents has been reported to influence the ability of fatty acids to act as skin penetration enhancers (Elyan et al 1996;Bhatia and Singh 1998;Takeuchi et al 1998;Taguchi et al 1999). In this study, the effects of 12 fatty acids on the transdermal delivery of diclofenac in vitro have been systematically investigated.…”

Untitled

“…A saturated fatty acid might enhance the solubility and unsaturated fatty acid provided lipophilicity. [18,19] This two feature of fatty acid of CB is very helpful for low aqueous soluble and low bioavailable drug-like rosuvastatin. In the present investigation, monounsaturated (oleic acid) and polyunsaturated (linoleic acid) were tried in a combination to get both the phenomenon hydrophilicity and hydrophobicity in a single formulation.…”