2005
DOI: 10.1007/s10529-005-1532-4
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Enhancement of polyunsaturated fatty acid production by cerulenin treatment in polyunsaturated fatty acid-producing bacteria

Abstract: When docosahexaenoic acid (DHA)-producing Moritella marina strain MP-1 was cultured in the medium containing 0.5 microg cerulenin ml-1, an inhibitor for fatty acid biosynthesis, the cells grew normally, but the content of DHA in the total fatty acids increased from 5.9-19.4%. The DHA yield of M. marina strain MP-1 cells also increased from 4 to 13.7 mg l-1 by cerulenin treatment. The same effect of cerulenin was observed in eicosapentaenoic acid (EPA)-producing Shewanella marinintestina strain IK-1 grown in th… Show more

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Cited by 38 publications
(29 citation statements)
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“…This titer is 5-fold higher than the 13.7 mg/L achieved by supplementing M. marina culture with the antibiotic cerulenin (Morita 2005b), but drastically lower than the 4.3 g/L reported to be produced by the marine thraustochytrid Aurantiochyrium limacinum (Nagano 2009). …”
Section: Discussionmentioning
confidence: 61%
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“…This titer is 5-fold higher than the 13.7 mg/L achieved by supplementing M. marina culture with the antibiotic cerulenin (Morita 2005b), but drastically lower than the 4.3 g/L reported to be produced by the marine thraustochytrid Aurantiochyrium limacinum (Nagano 2009). …”
Section: Discussionmentioning
confidence: 61%
“…Existing studies with MP-1 have used complex media (Morita et al 2005a;Morita et al 2005b). Here we have tested MOPS minimal media, modified to contain 20 g/L NaCl (MMOPS), for its ability to support M. marina MP-1 growth and DHA production at 10, 15 and 20 0 C (Table 1).…”
Section: Defined Media Supports Dha Productionmentioning
confidence: 99%
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