Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase

Comparative Anticancer Effects of Flavonoids and Diazepam in Cultured Cancer Cells

“…PK11195 has been reported to generate a reversal action on the chemoresistance in cancer cells, independent of the direct activation of PBR. [25][26][27] In this study, PK11195, a putative chemosensitizer, showed further enhancement of their anticancer effects.…”

TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance

“…loading, lowered CRC with respect to control sample (p \ 0.05). Data refer to the mean ± SEM of three independent experiments (Color figure online) restoration of cell survival which could be due to a compensatory cell mechanism [71]. On the other hand, ligand-TSPO interaction could activate other mechanisms, such as neurosteroid new synthesis, thus determining cellular responses able to reverse the death signals.…”

Role of transglutaminase 2 in PAC1 receptor mediated protection against hypoxia-induced cell death and neurite outgrowth in differentiating N2a neuroblastoma cells

“…Rp-cAMPs (10-100 µM; Werner et al, 2014;Mangiavacchi and Wolf, 2004;Wang et al, 2012;Pratt et al, 2016;Vallejo and Vallejo, 2002); Ro 31-8220 (1-10 µM; Lee et al, 2013;Montejo-López et al, 2016), PD 98059 (10-50 µM; Sutter et al, 2004;Kim et al, 2008), SP 600125 (20 µM; Hah et al, 2013;Kim et al, 2010) and Akt inhibitor XI (1 µM; Frampton et al,2012;Rybchyn et al, 2011 Inhibitor Cocktail 2). Cell lysates were scraped and clarified by centrifugation at 4°C for 10 min at 14000 x g prior to being assayed for TG activity using the biotin-labeled cadaverine incorporation assay (see below).…”