Enhancement of osteoinduction by vitamin D metabolites in rachitic host rats

Atkin, I.; Dean, David D.; Muniz, Ofelia E.; Agundez, Agueda; Castiglione, G.; Cohen, Galit; Howell, David S.; Ornoy, Asher

doi:10.1002/jbmr.5650070803

Cited by 16 publications

(2 citation statements)

References 28 publications

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“…По окончании курса лечения наблюдались значительные улучшения в показателях минерализации кости и формирования костного матрикса. В контрольной группе все соответствовало норме [ 18 ] .…”

Section: влияние витамина D на процесс регенерации костной тканиunclassified

Influence of vitamin D on the reconstitutional processes of bone tissue: a review

Иванова,

Иванов,

Гусаров

et al. 2023

Clinical Dentistry (Russia)

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В данной статье представлен обобщенный, структурированный обзор результатов разных исследований, направленных на анализ влияния витамина D в целях профилактики заболеваний полости рта, на остеоинтеграцию дентальных имплантатов, процессы формирования костной мозоли, состояние тканей пародонта и на общее состояние иммунной системы у пациентов после оперативных вмешательств. На данный момент процессы сокращения сроков регенерации костной ткани являются актуальной проблемой не только в области челюстно-лицевой хирургии, но и в хирургии в целом. Цель — провести анализ отечественных и зарубежных литературных источников на наличие информации о влиянии витамина D на регенеративные процессы челюстно-лицевой области. Задача исследования — изучение влияния витамина D на реконструктивные процессы костной ткани и состояние полости рта у пациентов после оперативных вмешательств при добавлении данного метаболита в комплексную терапию. В статье приведены общие медицинские сведения о витамине D: способах его поступления и метаболизме в организме, а также о его взаимодействии с другими веществами и их влиянии на процессы гомеостаза; представлены рекомендуемые нормы данного метаболита в организме человека, его влияние на процессы регенерации костной ткани и заживление послеоперационных ран, представлены результаты клинико-лабораторных исследований в различных областях стоматологии, освещающих воздействие витамина D на состояние полости рта в целом. В связи с отсутствием широкого применения данного препарата в практике, на основании изложенных данных, рекомендовано пересмотреть вопрос о включении метаболита в процесс лечения пациентов с заболеваниями челюстно-лицевой области. Несмотря на существующие рекомендованные нормы, установленные ВОЗ и Ассоциацией эндокринологов, необходимо разработать схему приема витамина D у пациентов после оперативных вмешательств для оптимизации и сокращения сроков реабилитации на основании оценки клинических данных пациентов. The article presents a generalized structured review of the results of various research works aimed at the analysis of the effect of vitamin D in the prophylaxis of oral cavity diseases, on the osseointegration of dental implants, on the bone marrow formation, on the periodontal tissue condition, and on the general state of the immune system in patients after surgical interventions. At present, the processes of bone tissue regeneration period reduction is the real problem not only in the field of maxillofacial surgery, but also in surgery in general. Objective — to analyze domestic and foreign literature sources for information on the effect of vitamin D on the regenerative processes of the maxillofacial region. The aim of the research is to study the influence of vitamin D on reconstructive processes of bone tissues and oral cavity condition in patients after surgical interventions when this metabolite is added to the complex therapy. The article contains general medical information about vitamin D: the ways of its entrance and metabolism in the organism, as well as its interaction with other substances and their influence on homeostasis processes; the recommended rates of this metabolite in a human body are presented, its influence on regeneration of bone tissue and healing of postoperative wounds, the results of clinical and laboratory researches in different fields of dentistry, covering the influence of vitamin D on the state of oral cavity in general. . Due to the lack of widespread use of this drug in practice, it is recommended to reconsider the inclusion of the metabolite in the treatment of patients with diseases of the maxillofacial region on the basis of the presented data. Despite the existing recommended norms established by the WHO and the Endocrinology Association, it is necessary to develop a scheme of vitamin D administration in patients after surgical interventions in order to optimize and shorten the rehabilitation period, based on the evaluation of clinical data of patients.

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Section: влияние витамина D на процесс регенерации костной тканиunclassified

Influence of vitamin D on the reconstitutional processes of bone tissue: a review

Иванова,

Иванов,

Гусаров

et al. 2023

Clinical Dentistry (Russia)

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“…Следующим этапом было назначение препаратов 24,25-OHD3. После курса лечения в исследуемой группе наблюдалось значительное улучшение показателей минерализации и формирования костного матрикса [6].…”

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Influence of vitamin D deficiency on progression of inflammation and reparative healing in patients with orofacial region diseases

et al. 2019

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Григорьянц Артур Павлович-к.м.н., доцент кафедры пропедевтики стоматологических заболеваний ГБОУ ВПО ПСПбГМУ им. акад. И.П. Павлова Минздрава РФ; тел.: +7 (921) 907-55-45 Никитин Владимир Сергеевичассистент кафедры пропедевтики стоматологических заболеваний ГБОУ ВПО ПСПбГМУ им. акад. И.П. Павлова Минздрава РФ; тел.:

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24R,25-(OH)2D3 mediates its membrane receptor-dependent effects on protein kinase C and alkaline phosphatase via phospholipase A2 and cyclooxygenase-1 but not cyclooxygenase-2 in growth plate chondrocytes

Schwartz¹,

Sylvia

Toro

et al. 2000

J. Cell. Phys.

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Recent studies have shown that 24R,25-(OH)(2)D(3) mediates its effects on growth plate chondrocytes via membrane receptors. This study examined the roles of phospholipase A(2) (PLA(2)) and cyclooxygenase (Cox) in the mechanism of action of 24R, 25-(OH)(2)D(3) in resting zone chondrocytes in order to determine whether the activity of one or both enzymes provides a regulatory checkpoint in the signaling pathway resulting in increased protein kinase C (PKC) activity. We also determined whether constitutive or inducible Cox is involved. Cultures were incubated with 24R, 25-(OH)(2)D(3) for 90 min to measure PKC or for 24 h to measure physiological responses ([(3)H]-thymidine incorporation, alkaline phosphatase-specific activity, [(35)S]-sulfate incorporation). Based on RT-PCR and Northern blot analysis, resting zone chondrocytes express mRNAs for both Cox-1 and Cox-2. Levels of mRNA for both proteins were unchanged from control levels after a 24-h incubation with 24R,25-(OH)(2)D(3). To examine the role of Cox, the cultures were also treated with resveratrol (a specific inhibitor of Cox-1), NS-398 (a specific inhibitor of Cox-2), or indomethacin (a general Cox inhibitor). Cox-1 inhibition resulted in effects on proliferation, differentiation, and matrix production typical of 24R, 25-(OH)(2)D(3). In contrast, inhibition of Cox-2 had no effect, indicating that 24R,25-(OH)(2)D(3) exerts its effects via Cox-1. Inhibition of Cox-1 also blocked 24R,25-(OH)(2)D(3)-dependent increases in PKC. Activation of PLA(2) with melittin inhibited 24R, 25-(OH)(2)D(3)-dependent stimulation of PKC, and inhibition of PLA(2) with quinacrine stimulated PKC in response to 24R, 25-(OH)(2)D(3). Inclusion of resveratrol reduced the melittin-dependent inhibition of PLA(2) and caused an increase in quinacrine-stimulated PLA(2) activity. Metabolism of arachidonic acid to leukotrienes is not involved in the response to 24R, 25-(OH)(2)D(3) because inhibition of lipoxygenase had no effect. The effect of 24R,25-(OH)(2)D(3) was specific because 24S,25-(OH)(2)D(3), the biologically inactive stereoisomer, failed to elicit a response from the cells. These results support the hypothesis that 24R, 25-(OH)(2)D(3) exerts its effects via more than one signaling pathway and that these pathways are interrelated via the modulation of PLA(2). PKC regulation may occur at multiple stages in the signal transduction cascade.

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Enhancement of osteoinduction by vitamin D metabolites in rachitic host rats

Cited by 16 publications

References 28 publications

Influence of vitamin D on the reconstitutional processes of bone tissue: a review

Influence of vitamin D on the reconstitutional processes of bone tissue: a review

Influence of vitamin D deficiency on progression of inflammation and reparative healing in patients with orofacial region diseases

24R,25-(OH)2D3 mediates its membrane receptor-dependent effects on protein kinase C and alkaline phosphatase via phospholipase A2 and cyclooxygenase-1 but not cyclooxygenase-2 in growth plate chondrocytes

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