Enhancement of oral bioavailability of drugs using lipid-based carriers: a meta-analysis study

Nasser, Nayera; Hathout, Rania M.; Abd-Allah, Hend; Sammour, Omaima A.

doi:10.1080/03639045.2020.1851245

Cited by 12 publications

(9 citation statements)

References 38 publications

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“…Moreover, the delivery of drugs in a controlled manner is currently a topic of great importance for both the industry and academia, due to its huge benefits for healthcare [ 5 ]. Recently, the use of lipid-based nano-carriers has shown proven superiority over the conventional formulations in augmenting the bioavailability of oral drugs, via a study using quantitative meta-analysis [ 6 ]. The close affinity of those carriers with the lipidic nature of intestinal cell membranes may have contributed to this outcome.…”

Section: Introductionmentioning

confidence: 99%

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Do Polymeric Nanoparticles Really Enhance the Bioavailability of Oral Drugs? A Quantitative Answer Using Meta-Analysis

Hathout

2022

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The oral route remains one of the most popular and important routes of administration for drugs—one that warrants the development of advanced drug delivery systems, such as polymeric nanoparticles capable of enhancing the absorption and bioavailability of the used drugs. In this work, a systematic review of published works on several databases, followed by a meta-analysis, were utilized in order to navigate the published studies and access literature-based evidence about the capability of polymeric nanoparticulate systems to augment the absorption and bioavailability of orally administered drugs. The pharmacokinetic parameter of the area under the curve (AUC) was utilized as the “effect” of this meta-analytical study. The meta-analysis demonstrated a significant increase in AUC compared to conventional formulations. Furthermore, comparing the synthetic polymeric nanoparticles, versus their naturally-based administered counterparts, as subgroups of the meta-analysis, revealed no significant differences.

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Section: Introductionmentioning

confidence: 99%

“…Nowadays, meta-analysis is often implemented in the drug delivery field as it can be used to compare any new formulation or delivery system with a conventional one. It offers an important tool for decision-making in the pharmaceutical industry [ 6 , 15 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Do Polymeric Nanoparticles Really Enhance the Bioavailability of Oral Drugs? A Quantitative Answer Using Meta-Analysis

Hathout

2022

Gels

Self Cite

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“…Moreover, the delivery of drugs in a controlled manner is currently a topic of great importance for both the industry and academia due to its huge benefits in healthcare 5 . Recently, the use of lipid-based nano-carriers has proven superiority over the conventional formulations in augmenting the bioavailability of oral drugs using a quantitative meta-analysis study 6 . The close affinity of those carriers to the lipidic nature of the intestinal cell membranes may have contributed to this outcome.…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, the meta-analysis is being implemented in the drug delivery fields as it can be used to compare any new formulation or delivery system with a conventional one. It poses an important tool for the pharmaceutical industry decision-making 6,14,20,21 .…”

Section: Introductionmentioning

confidence: 99%

Do The Polymeric Nanoparticles Really Enhance The Bioavailability Of Oral Drugs? A Quantitative Answer Using Meta-analysis

Hathout¹

2022

Preprint

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The oral route remains one of the most popular and important routes of administration that warrants the development of advanced drug delivery systems such as the polymeric nanoparticles capable of enhancing the absorption and bioavailability of the used drugs. In this work, systematic reviewing through several databases followed by a meta-analysis study were utilized in order to navigate the published studies and reach literature-based evidence about the capability of polymeric nanoparticulate systems of augmenting the absorption and the bioavailability of the orally administered drugs. The pharmacokinetic parameter; area under the curve (AUC) was utilized as the “effect” of the meta-analysis study. The meta-analysis study demonstrated the significant increase AUC as compared to the conventional formulations. Furthermore, comparing the synthetic polymeric nanoparticles versus the naturally-based counterparts, as subgroups of the meta-analysis, revealed no significant differences.

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“…Specifically, liposomal drug delivery is a promising strategy, as many liposome encapsulated drugs are currently undergoing clinical trials [15][16][17]. Liposomes act as an effective vehicle to bring active compounds to their target site, therefore increasing drug bioavailability [18,19]. This allows liposomes to decrease the dosage required to achieve a therapeutic effect and therefore improve the safety profile of these drugs.…”

Section: Introductionmentioning

confidence: 99%

Resurrecting the Dead: Mitigating Efflux-Pump Inhibitor Toxicity using a Liposomal Delivery System to Recover Efficacy of Antimicrobial Drugs

Ray

Nguyen

et al. 2021

URNCST Journal

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Introduction: Antimicrobial resistance (AMR) has become concerningly prevalent on a global scale as many infectious agents have evolved to evade antimicrobials effects, making it difficult to treat infectious diseases. Pseudomonas aeruginosa is a multiresistant bacteria that requires urgent attention as it is detrimental in lung infections. Activity of membraneembedded efflux pumps, such as the MexAB-OprM pump, is a principal mechanism by which bacterial species become resistant to antimicrobials. Efflux pump inhibitors (EPIs) have recently emerged as a strategy to prevent the expulsion of administered antimicrobials, thereby resensitizing resistant bacteria to antibiotics. Phenylalanine-arginine β-naphthylamide (PAβN) is an EPI that inhibits a number of different pumps, including the MexAB-OprM efflux system. Despite EPIs providing a partial solution to AMR, they have been shown to be toxic to humans, which has impeded their entry into clinical application. We propose that by inserting the PAβN into a liposomal delivery system, the cytotoxic effects against human cells will be lowered without decreasing the EPI's inhibitory activity. Methods: Resistant P. aeruginosa strains will be administered with liposomes jointly encased with PAβN and ampicillin to ensure both are delivered to the same cell, while testing for changes in antimicrobial efflux activity and bacterial growth, indicative of restored antimicrobial effectiveness. Efflux activity and inhibited growth will be measured using an ethidium bromide efflux assay and a minimum inhibitory concentration assay, respectively. Human pulmonary epithelial cells will be exposed to liposomal-encased PAβN to study changes to EPI cytotoxicity, with cell viability being measured using a Cell Titer Blue assay. Results: Liposomal EPI are expected to maintain inhibitory activity and resistant bacteria would become re-susceptible to antibiotics when treated with the liposomal EPI. Discussion: By analyzing efflux rate to measure the liposomal EPI's activity, its activity level should be comparable to free EPI. The resensitization assay would show that the bacteria are susceptible to antibiotics again. Conclusion: If effective, EPIs may become a potential therapeutic to combat AMR by reviving the use of antimicrobials that have become ineffective. Restoring the activity of already approved antibiotics through potential co-administration with liposome-encapsulated EPIs will be a cost-effective approach to combat AMR.

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Enhancement of oral bioavailability of drugs using lipid-based carriers: a meta-analysis study

Cited by 12 publications

References 38 publications

Do Polymeric Nanoparticles Really Enhance the Bioavailability of Oral Drugs? A Quantitative Answer Using Meta-Analysis

Do Polymeric Nanoparticles Really Enhance the Bioavailability of Oral Drugs? A Quantitative Answer Using Meta-Analysis

Do The Polymeric Nanoparticles Really Enhance The Bioavailability Of Oral Drugs? A Quantitative Answer Using Meta-analysis

Resurrecting the Dead: Mitigating Efflux-Pump Inhibitor Toxicity using a Liposomal Delivery System to Recover Efficacy of Antimicrobial Drugs

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