Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles

Ahmad, Niyaz; Ahmad, Rizwan; Alam, Md. Aftab; Ahmad, Farhan Jalees

doi:10.1186/s13065-018-0434-1

Cited by 58 publications

(43 citation statements)

References 58 publications

(61 reference statements)

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“…The EE and LE of the nanospheres were determined (Yang et al, 2017). The nanospheres were characterized using FTIR (Abbas et al, 2018;Dong et al, 2018), electron microscopy (Shi et al, 2016;Nantachit et al, 2017;Tao et al, 2018), and laser particle size analysis (Couvreur et al, 2002;Zhang et al, 2015;Shi et al, 2016;Ahmad et al, 2018;Panchu et al, 2018;von Halling Laier et al, 2018). The results showed that C-PC/CMC-CD55sp nanospheres were successfully constructed.…”

Section: Discussionmentioning

confidence: 99%

“…Nanospheres morphology was observed using a transmission electron microscope (Shi et al, 2016;Nantachit et al, 2017;Tao et al, 2018). Zeta potential (surface charge) and particle size (nanospheres size) were measured using a laser particle size analyzer at 25°C (Zhang et al, 2015;Ahmad et al, 2018;Panchu et al, 2018;von Halling Laier et al, 2018).…”

Section: Synthesis Of C-pc/cmc-cd55sp Nanospheresmentioning

confidence: 99%

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Targeted Antitumor Mechanism of C-PC/CMC-CD55sp Nanospheres in HeLa Cervical Cancer Cells

Liu

Jiang

et al. 2020

Front. Pharmacol.

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In vitro studies had shown that C-Phycocyanin (C-PC) inhibited cervical cancer HeLa cells growth. We constructed C-PC/CMC-CD55sp nanospheres using C-PC, Carboxymethyl Chitosan (CMC), and CD55 ligand peptide (CD55sp) to allow for targeted antitumor effects against HeLa cells in vitro and in vivo. The characteristics of the nanospheres were determined using FTIR, electron microscopy, and laser particle size analysis. Flow cytometry, laser confocal microscopy and small animal imaging system showed the targeting of C-PC/CMC-CD55sp nanospheres on HeLa cells. Subsequently, the proliferation and apoptosis were analyzed by Cell Counting Kit-8 (CCK-8), flow cytometry, TUNEL assay and electron microscopy. The expression of the apoptosisrelated protein was determined using western blot. The stainings of Hematoxylin and Eosin (HE) were employed to evaluate the cell condition of tumor tissue sections. The cytokines in the blood in tumor-bearing nude mice was determined using ELISA. These results showed that C-PC/CMC-CD55sp nanospheres were successfully constructed and targeted HeLa cells. The constructed nanospheres were more effective than C-PC alone in inhibiting the proliferation and inducing apoptosis in HeLa cells. We also found that C-PC/CMC-CD55sp nanospheres had a significant inhibitory effect on the expression of antiapoptotic protein Bcl-2 and a promotion on the transformation of caspase 3 to cleaved caspase 3. C-PC/CMC-CD55sp nanospheres played an important role in tumor suppression, reduced the expression TGF-b, and increased IL-6 and TNF-a. This study demonstrates that the constructed new C-PC/CMC-CD55sp nanospheres exerted targeted antitumor effects in vivo and in vitro which provided a novel idea for application of C-PC, and provided experimental basis for comprehensive targeted treatment of tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Synthesis Of C-pc/cmc-cd55sp Nanospheresmentioning

confidence: 99%

Targeted Antitumor Mechanism of C-PC/CMC-CD55sp Nanospheres in HeLa Cervical Cancer Cells

Liu

Jiang

et al. 2020

Front. Pharmacol.

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“…The use of these polymeric NPs can provide improvements in cancer therapy by exploring new routes of administration of some drugs, combining some active substances to potentiate their action or combining with other therapies like gene therapy. Ahmad et al [ 136 ] proposed an enhancement of doxorubicin oral bioavailability through surface modified biodegradable polymeric NPs as an alternative to intravenous administration. They studied drug-loaded PEGylated PLGA NPs pharmacokinetics compared to doxorubicin in Wistar rats.…”

Section: Polymeric Nanoparticles In Oncologic Treatmentmentioning

confidence: 99%

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

et al. 2020

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The complexity of some diseases—as well as the inherent toxicity of certain drugs—has led to an increasing interest in the development and optimization of drug-delivery systems. Polymeric nanoparticles stand out as a key tool to improve drug bioavailability or specific delivery at the site of action. The versatility of polymers makes them potentially ideal for fulfilling the requirements of each particular drug-delivery system. In this review, a summary of the state-of-the-art panorama of polymeric nanoparticles as drug-delivery systems has been conducted, focusing mainly on those applications in which the corresponding disease involves an important morbidity, a considerable reduction in the life quality of patients—or even a high mortality. A revision of the use of polymeric nanoparticles for ocular drug delivery, for cancer diagnosis and treatment, as well as nutraceutical delivery, was carried out, and a short discussion about future prospects of these systems is included.

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“…In the PEGylated doxorubicin (DOX) loaded PLGA-Nanoparticles (PEGylated-DOX-PLGA-NPs) observed a 6.8-fold oral bioavailability as compared to DOX-S in pharmacokinetics studies. 68 In addition, Feeney et al 69 modified lipid nanoparticles (LN) by using carrier materials of hydrogenated castor oil (HCO) and castor oil (CO) (containing PEG groups). They found that the relative bioavailability (defined as the ratio of AUC 0-∞ for the modified LN and its structurally analogous LN) of the formulations was 120% and 182% for HCO and CO formulations, respectively.…”

Section: Pegylated Drug Delivery Vehiclesmentioning

confidence: 99%

<p>The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs</p>

Wang

Feng

et al. 2020

IJN

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Oral administration has been the most common therapeutic regimen in various diseases because of its high safety, convenience, lower costs, and high compliance of patients. However, susceptible in hostile gastrointestinal (GI) environment, many drugs show poor permeability across GI tract mucus and intestinal epithelium with poor oral absorption and limited therapeutic efficacy. In recent years, nanoparticulate drug delivery systems (NDDS) have become a hot research spot because of their unique advantages including protecting drug from premature degrading and interacting with the physiological environment, increasing intracellular penetration, and enhancing drug absorption. However, a slight change in physicochemistry of nanoparticles can significantly impact their interaction with biological pathways and alter the oral bioavailability of drugs. Hence, this review focuses on the factors affecting oral bioavailability from two aspects. On the one hand, the factors are the biochemical and physiological barriers in oral drugs delivery. On the other hand, the factors are the nanoparticle properties including size, surface properties, and shape of nanoparticles.

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Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles

Cited by 58 publications

References 58 publications

Targeted Antitumor Mechanism of C-PC/CMC-CD55sp Nanospheres in HeLa Cervical Cancer Cells

Targeted Antitumor Mechanism of C-PC/CMC-CD55sp Nanospheres in HeLa Cervical Cancer Cells

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

<p>The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs</p>

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