Enhancement of non-specific cytotoxic activity of leucocytes in rainbow trout Oncorhynchus mykiss injected with growth hormone

Increase in haemolytic activity of serum from rainbow troutOncorhynchus mykissinjected with exogenous growth hormone

“…T-lymphocytes have receptors for GH and prolactin, and several immune responses are regulated by these hormones. GH injected into fish increases mitogenic responses of lymphocytes (Sakai et al, 1996a) and NK cell activities (Kajita et al, 1992). In addition, Sakai et al (1995Sakai et al ( , 1996b have reported that exogenous GH given to rainbow trout, Oncorhynchus mykiss, increased the production of superoxide anion in leucocytes.…”

Growth performance and respiratory burst activity in rainbow trout treated with growth hormone and vaccine

“…Identical responses have been reported in rainbow trout in vitro (Sakai et al, 1995(Sakai et al, , 1996Kajita et al, 1992b); while specific receptors for GH and the influence of GH upon leucocyte growth (Calduch-Giner et al, 1995), have been demonstrated in red sea bream. Moreover, phagocytic index and capacity are also elevated in vitro, following GH priming in the latter species (CalduchGiner et al, 1997).…”

Effects of the “all-fish” GH (growth hormone) transgene expression on resistance to Ichthyophthirius multifiliis infections in common carp, Cyprinus carpio L.

“…(Oncorhynchus mykiss) (Kajita et al, 1992;Sakai et al, 1995Sakai et al, , 1996a and respiratory burst activity of leukocytes in rainbow trout and Mediterranean sea bass (Dicentrarchus labrax) (Sakai et al, 1996c;Kitlen et al, 1997;Muñoz et al, 1998). Combined with Wang et al's (2006) findings, it was possible that F 4 transgenics have stronger non-specific immune functions than non-transgenics and controls, especially greater amount and activity of the immune cells.…”