Enhancement of Neuroprotection of Mulberry Leaves (Morus alba L.) Prepared by the Anaerobic Treatment against Ischemic Damage

Kang, Tong Ho; Oh, Hye Rim; Jung, Sun Moon; Ryu, Jong Hoon; Park, Mee Won; Park, Yongkon; Kim, Sun Yeou

doi:10.1248/bpb.29.270

Cited by 50 publications

(21 citation statements)

References 22 publications

(11 reference statements)

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“…Also, its constituents have shown for antimicrobial, antiviral, cardioprotective, hepatoprotective, hypolipidemic, hypouricemic, and neuroprotective activ-ities (Park et al, 1990(Park et al, , 2003Oh et al, 2002;Du et al, 2003;El-Beshbishy et al, 2006). In addition, cyanidin glucose isolated from M. alba inhibited cerebral ischemic condition caused by oxygen-glucose deprivation in PC12 cells (Kang et al, 2006). A number of prenylated flavonoids, stilbenes, benzofurans, terpenes, alkaloids, and other phenolic compounds were previously reported as chemical constituents of this tree Ueda et al, 1982Ueda et al, , 1984Hano et al, , 1989aHano et al, , 1989bQiu et al, 1996;Asano et al, 2001;Kusano et al, 2002;Lee et al, 2002;Zhang et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells

et al. 2011

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Three known 2-arylbenzofurans, moracin P (1), moracin O (2) and mulberrofuran Q (3) were isolated from the MeOH extract of the Mori Cortex Radicis. These compounds 1-3 enhanced cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells, which was measured by MTT reduction assay. (EC(50) values of 10.4, 12.6, and 15.9 μM, respectively). In addition, the compounds 1-3 were examined for their inhibitory effect on OGD-induced ROS production by FACS analysis. We observed these compounds reduced ROS production in OGD-induced cell death (IC(50) values of 1.9, 0.3 and 12.1 μM, respectively). Consequently, reactive oxygen species (ROS) were overexpressed in OGD-induced cells and all three compounds reduced ROS induced by OGD in dosedependent manner. Taken together, compounds 1-3 might protect neuronal cell death against the oxidative stress induced by OGD, though further studies in vitro and in vivo models are necessary.

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells

et al. 2011

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“…[6][7][8] Some studies have reported many different medicinal properties of mulberry leaves (Morus alba) like neuroprotective property, cardioprotective property, antidepressant property. [9][10][11] It is used as antiinflammatory, diuretic, expectorant and antidiabetic in traditional Chinese medicine. [12][13][14] So this study is undertaken to evaluate the hypoglycaemic effect of aqueous extract of leaves of Morus alba in Alloxan induced diabetic albino rats.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of hypoglycaemic activity of morus alba with oral hypoglycaemic drug (metformin) in alloxan induced diabetic rats

Madalageri¹,

Nagaraj²

2016

Int J Basic Clin Pharmacol

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“…4 Some studies have reported many different medicinal properties of mulberry leaves (Morus alba) like neuroprotective property, cardioprotective property, antidepressant property. 5,6,7 It is used as anti-inflammatory, diuretic, expectorant and antidiabetic in traditional Chinese medicine. 8,9,10 So this study is undertaken to evaluate the hypoglycaemic effect of aqueous extract of leaves of Morus alba in Alloxan induced diabetic albino rats.…”

Section: Introductionmentioning

confidence: 99%

Evaluation and Comparative Study of Hypoglycaemic Activity of Morus Alba With Oral Hypoglycaemic Drug (Glibenclamide) in Alloxan Induced Diabetic Rats

Madalageri¹,

Nagaraj²,

Nidamarthi³

2016

jemds

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Diabetes mellitus is a metabolic disorder due to relative or absolute lack of insulin, resulting in elevated blood glucose levels in association with long-term vascular and neurological complications. Despite the availability of many antidiabetic medicines in the market, diabetes and its related complications continue to be major medical problems. The currently used hypoglycaemic drugs in the treatment of diabetes are not completely effective and are associated with adverse effects both in the short and long run. Some studies have reported many different medicinal properties of mulberry leaves (Morus alba) like neuroprotective property, cardioprotective property, anti-depressant property. It is used as an anti-inflammatory, diuretic, expectorant and antidiabetic in traditional Chinese medicine. So this study is undertaken to evaluate the hypoglycaemic effect of aqueous extract of leaves of Morus alba in Alloxan induced diabetic albino rats. OBJECTIVES To study the hypoglycaemic activity of Morus alba in Alloxan induced model of diabetes in albino rats. To compare the hypoglycaemic activity of Morus alba with that of standard drug Glibenclamide. METHODSTotal 24 albino rats of either sex weighing 150-200 gms were selected and randomly divided into 4 equal groups containing 6 rats in each group. First group (Non-diabetic control) was given normal saline (0.5 mL). Other 3 groups were induced diabetes by giving Alloxan (150 mg/kg ip). They were subdivided into diabetic control group receiving normal saline (0.5 mL), standard control group receiving Glibenclamide (0.5 mg/kg body weight) and test group receiving Morus alba extract (600 mg/kg). Fasting blood sugar level was estimated on day 0, 1, 3, 7, 14, 21 and 28 by using glucometer. Data were statistically analysed by Tukey's Post Hoc test and ANOVA. RESULTSMorus alba at the above doses significantly reduced blood glucose levels as compared to control group (p<0.01), but as compared to standard drugs (Glibenclamide) it is statistically insignificant (p>0.05). CONCLUSIONThe result suggests that Morus alba leaves have hypoglycaemic activity.

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Enhancement of Neuroprotection of Mulberry Leaves (Morus alba L.) Prepared by the Anaerobic Treatment against Ischemic Damage

Cited by 50 publications

References 22 publications

Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells

Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells

Comparative study of hypoglycaemic activity of morus alba with oral hypoglycaemic drug (metformin) in alloxan induced diabetic rats

Evaluation and Comparative Study of Hypoglycaemic Activity of Morus Alba With Oral Hypoglycaemic Drug (Glibenclamide) in Alloxan Induced Diabetic Rats

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