Enhancement of Natural Resistance to Influenza Virus in Lipopolysaccharide-Responsive and -Nonresponsive Mice by
            <i>Propionibacterium acnes</i>

Gangemi, J. David; Hightower, James A.; Jackson, Ronnie A.; Maher, Michael H.; Welsh, Marcia G.; Sigel, M. Michael

doi:10.1128/iai.39.2.726-735.1983

Cited by 17 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that mice administrated with P. acnes enhanced the resistance to influenza virus (Gangemi et al, 1983) and tumor formation (Murano and Cummins, 1989;Mussalem et al, 2006) as well as augmented phagocytic activities (Webster et al, 1979(Webster et al, , 1981aGangemi et al, 1983). These data implied that inactivated P. acnes vaccines may increase host immunity.…”

Section: Discussionmentioning

confidence: 84%

Antibodies Elicited by Inactivated Propionibacterium acnes-Based Vaccines Exert Protective Immunity and Attenuate the IL-8 Production in Human Sebocytes: Relevance to Therapy for Acne Vulgaris

Nakatsuji

Liu

Huang

et al. 2008

Journal of Investigative Dermatology

View full text Add to dashboard Cite

Propionibacterium acnes is a key pathogen involved in the progression of inflammation in acne vulgaris. We examined whether vaccination against P. acnes suppressed P. acnes-induced skin inflammation. Inactivation of P. acnes with heat was employed to create a P. acnes-based vaccine. Intranasal immunization in mice with this inactivated vaccine provoked specific antibodies against P. acnes. Most notably, immunization with inactivated vaccines generated in vivo protective immunity against P. acnes challenge and facilitated the resolution of ear inflammation in mice. In addition, antibodies elicited by inactivated vaccines effectively neutralized the cytotoxicity of P. acnes and attenuated the production of proinflammatory cytokine IL-8 in human sebocyte SZ95 cells. Intranasal immunization using heat-inactivated P. acnes-based vaccines provided a simple modality to develop acne vaccines. These observations highlight the concept that development of vaccines targeting microbial products may represent an alternative strategy to conventional antibiotic therapy.

show abstract

Section: Discussionmentioning

confidence: 84%

Antibodies Elicited by Inactivated Propionibacterium acnes-Based Vaccines Exert Protective Immunity and Attenuate the IL-8 Production in Human Sebocytes: Relevance to Therapy for Acne Vulgaris

Nakatsuji

Liu

Huang

et al. 2008

Journal of Investigative Dermatology

View full text Add to dashboard Cite

show abstract

“…One nism acts in isolation. Considering that FIV used can: (a) enhance the activities of pulmonary NK cells (Table I); (b) increase the H,02 secretion of macrophages [Arora and Houde, 19921 and PMNL (Table I); (c) initiate the early resistance that declines with time; and (d) other microbial products with similar properties have been shown to provide the nonspecific protection against experimental infection [Glasgow et al, 1977;Spencer et, al., 1977;Gangemi et al, 1983;Mak et al, 19831 it is plausible that the viral preparations stimulated the first line of defense of natural resistance mechanisms to impede the progress of infection in mice so that other immune mechanisms could be developed.…”

Section: Discussionmentioning

confidence: 99%

Administration of inactivated and detergent‐treated influenza virus to mice before virus challenge reduces mortality

Arora

1993

Journal of Medical Virology

View full text Add to dashboard Cite

Formalin-inactivated virus (FIV) and the detergent-treated virus (DTV) preparations were tested for their ability to enhance the resistance of mice to experimental influenza infection. FIV (100 micrograms) was administered intravenously to mice. After 24 hr, animals were challenged with 5 LD50 dose intranasally. FIV-treated and non-treated (control) mice had 10% and 100% mortality, respectively. Similar results were obtained with the DTV (40 micrograms) preparation. The pulmonary virus titer of FIV-treated mice was lower when compared with the control. Mechanisms other than acquired immunity may have conferred the early resistance to virus infection in mice.

show abstract

“…The non-specific activation of macrophages (APCs) and the enhancement of cytokine production by CT cause the subsequent enhance- ment of the adaptive immune responses against influenza viruses, which results in complete protection against infection. Similarly, pretreatment of mice with Propionibacterium acnes (Corynebacterium parvum) or baculovirus before a lethal viral challenge results in lower lung-viral titers and lower mortality (20)(21)(22). In these cases, various constituents of the pathogens used for the pretreatment can activate macrophages and dendritic cells (DCs) via members of the Toll-like receptor (TLR) family on these cells to induce protection against infection (23)(24)(25).…”

Section: -2 Enhancement Of Innate Immunitymentioning

confidence: 99%

Defense Mechanisms against Influenza Virus Infection in the Respiratory Tract Mucosa

Tamura,

Kurata

2004

Jpn J Infect Dis

181

View full text Add to dashboard Cite

The respiratory tract mucosa is not only the site of infection for influenza viruses but also the site of defense against virus infection. Viruses are initially detected and destroyed non-specifically by innate immune mechanisms, but if the viruses escape the early defense mechanisms, they are detected and eliminated specifically by adaptive immune mechanisms. The major adaptive immune mechanisms are as follows. (i) Specific secretory-IgA (S-IgA) antibodies (Abs) and CTLs (CD8 + cytotoxic T lymphocytes) are involved in the recovery from influenza following viral infection of naïve mice. (ii) Preexisting specific S-IgA and IgG Abs in the immunized animals are involved in viral elimination by forming virus-Ig complexes shortly after re-infection. By their polymeric nature, the S-IgA Abs, which are carried to the mucus by transepithelial transport used for dimeric IgA (dIgA) Abs, provide not only protection against homologous virus infection but also cross-protection against drift virus infection. The IgG Abs, which transude from the serum to the mucus by diffusion, provide protection against homologous virus infection. They are largely distributed on the alveolar epithelia to prevent influenza pneumonia. (iii) In the absence of Abs in the pre-immunized animals, the production of specific IgA and IgG Abs by B memory cells is accelerated after re-infection, and these antibodies play a role in viral elimination from day 3 onwards after re-infection. (iv) In epithelial cells of infected animals, specific dIgA Abs being trafficked through the epithelial cells may be involved in the prevention of viral assembly by binding to newly synthesized viral proteins. (v) In the pre-immunized animals, CTL production by memory T cells is also accelerated and these cells appear to participate in the killing of the host cells infected with different subtype viruses (within the same type) from day 3 onwards after re-infection. (vi) Similarly, memory Th1 cells that mediate an accelerated delayed-type hypersensitivity response are involved in blockade of virus replication by secreting IFN-γ in mice challenged with different subtype viruses. These defense mechanisms suggest that the development of a mucosal vaccine, capable of inducing S-IgA Abs, which provide cross-protection against variant viruses within the same subtype, serum IgG Abs to prevent lethal influenza pneumonia and CTLs, which provide broad cross-protection against different subtype viruses, is strategically important to control influenza.

show abstract

Enhancement of Natural Resistance to Influenza Virus in Lipopolysaccharide-Responsive and -Nonresponsive Mice by Propionibacterium acnes

Cited by 17 publications

References 37 publications

Antibodies Elicited by Inactivated Propionibacterium acnes-Based Vaccines Exert Protective Immunity and Attenuate the IL-8 Production in Human Sebocytes: Relevance to Therapy for Acne Vulgaris

Antibodies Elicited by Inactivated Propionibacterium acnes-Based Vaccines Exert Protective Immunity and Attenuate the IL-8 Production in Human Sebocytes: Relevance to Therapy for Acne Vulgaris

Administration of inactivated and detergent‐treated influenza virus to mice before virus challenge reduces mortality

Defense Mechanisms against Influenza Virus Infection in the Respiratory Tract Mucosa

Contact Info

Product

Resources

About