Enhancement of mediodorsal thalamus rescues aberrant belief dynamics in a mouse model with schizophrenia-associated mutation
Tingting Zhou,
Yi-Yun Ho,
Ray X. Lee
et al.
Abstract:Optimizing behavioral strategy requires belief updating based on new evidence, a process that engages higher cognition. In schizophrenia, aberrant belief dynamics may lead to psychosis, but the mechanisms underlying this process are unknown, in part, due to lack of appropriate animal models and behavior readouts. Here, we address this challenge by taking two synergistic approaches. First, we generate a mouse model bearing point mutation in Grin2a (Grin2aY700X+/-), a gene that confers high-risk for schizophreni… Show more
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