Enhancement of magnetic resonance contrast effect using ionic magnetic clusters

Seo, Sung Baek; Yang, Jaemoon; Lee, Tong Il; Chung, Chan‐Hwa; Song, Yong Jin; Yoon, Ho Geun; Huh, Yong Min; Haam, Seungjoo

doi:10.1016/j.jcis.2007.11.026

Cited by 21 publications

(26 citation statements)

References 30 publications

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“…The nanoemulsion surface was then stabilized using polysorbate 80 dissolved in an aqueous phase. The PMNPs within the nanoemulsion assembled and packed into MNCs during solvent evaporation [23,27,32]. To control MNC size for maximizing T2 relaxivity, the polysorbate 80 concentration was adjusted.…”

Section: Resultsmentioning

confidence: 99%

“…MNCs have been fabricated either by self-assembly or through direct solution growth. The common goal of these synthetic methods was to control the size of MNCs because T2 relaxivity increases are proportional to particle size [23,24]. However, the signal enhancement provided by MNCs still remains unsatisfactory because the studies about the density of individual MNPs consisting MNCs have not been concerned yet.…”

Section: Introductionmentioning

confidence: 99%

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Double-ligand modulation for engineering magnetic nanoclusters

et al. 2013

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Magnetic nanoclusters (MNCs) are agglomerated individual magnetic nanoparticles (MNPs) that show great promise in increasing magnetic resonance imaging (MRI) sensitivity. Here, we report an effective strategy to engineer MNCs based on double-ligand modulation to enhance MRI sensitivity. The oleic acid-coated individual MNPs self-assembled and then were enveloped by polysorbate 80, using a nanoemulsion method to prepare MNCs. By modulating the amounts of the two ligands, and thus the size and magnetic content of the resultant MNCs, we were able to enormously improve MRI sensitivity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Double-ligand modulation for engineering magnetic nanoclusters

et al. 2013

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“…It is important to stress that both single core and clustered IONPs were prepared with the same coating polymer, which has not been previously reported, to the best of our knowledge. Some recent reports have shown that the MRI contrast, e.g., the signal drop with T 2 weighted imaging, can be significantly enhanced by clustered IONPs [12,[27][28][29][30]. However, the samples of single or clustered IONPs employed were coated with different materials which may have affected their magnetic properties [12,28,31].…”

Section: Resultsmentioning

confidence: 99%

Preparation and control of the formation of single core and clustered nanoparticles for biomedical applications using a versatile amphiphilic diblock copolymer

et al. 2010

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We report the application of a versatile diblock copolymer, poly(ethylene oxide)-b-poly(γ-methacryloxypropyl trimethoxysilane) (PEO-b-PγMPS), to prepare nanocrystals such as iron oxide nanoparticles or quantum dots, with either a single core or multi-core cluster, for biomedical applications. This amphiphilic copolymer comprises both a hydrophilic PEO segment and a hydrophobic segment with a "surface anchoring moiety" (the silane group) which can interact effectively with the hydrophobic nanocrystals through ligand exchange. One of the unique features of this work is that we can control the formation of either single core nanoparticles or multi-core nanoclusters by simply varying the conditions of ligand exchange and aging of the mixture of block copolymer and nanoparticles without needing to change the copolymer. The morphologies of the resulting single core nanoparticles or multi-core nanoclusters were confirmed by dynamic light scattering and transmission electron microscopy. The clustered nanoparticles exhibit enhanced physicochemical properties that are beyond those expected from a simple accumulation of individual nanoparticles. Additionally, the hybrid nanoparticles containing both magnetic iron oxide nanoparticles and optical quantum dots obtained using our strategy provide have combined magnetic and optical functionalities that allow for potential new and expanded biomedical applications, as demonstrated by their use for magnetic resonance imaging and biomarker-targeted cell imaging.

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“…Thus, PMMA is needed to fabricate monodispersed nanoparticles. In addition, adapted PMMA is a medium substrate to assist in the formation of clustered nanocomposites, because MNCs can be easily fabricated into the PMMA matrix by the hydrophobic interaction between methylene groups of PMMA and lauric acid on the surface of MNCs [21].…”

Section: Resultsmentioning

confidence: 99%