Enhancement of long-term memory retention by Colostrinin in one-day-old chicks trained on a weak passive avoidance learning paradigm

Colostrum from different mammalian species—A rich source of colostrinin

“…The analysis of the N-terminal amino-acid sequence (data not shown) confirmed that the contaminating protein, migrating in SDS-PAGE somewhat more slowly than the myoglobin standard (17 kDa), was b-lactoglobulin and that of 14.2 kDa was likely a-lactalbumin. It is worth noting, however, that the evidence, presented by Stewart and Banks (2006), showing positive effect of the CLN preparation obtained according to Kruzel et al (2004) on retention of chicks' memory, proved that its activity was not affected by contaminating proteins.…”

“…Recently, 1-day-old domestic chicks were used as a model system to study the effect of colostralderived peptides on retention of memory. In a single onetrial learning paradigm, CLN demonstrated widespread efficacy as a cognitive enhancer even in animals other than mammals (Stewart & Banks, 2006).…”

Colostrinin™: a naturally occurring compound derived from mammalian colostrum with efficacy in treatment of neurodegenerative diseases, including Alzheimer's

“…CLN at low doses (4 µg/rat) facilitated the acquisition of spatial learning of aged (13-month-old) but not young (3-month-old) rats. In young domestic chicks, learning on a passive avoidance task was also improved whether CLN was administered intraperitoneally or intraventricularly [26] .…”

“…The research published in the following paper [26] was partly funded by ReGen Therapeutics, who provided Colostrinin for testing: Stewart MG, Banks D. Enhancement of longterm memory retention by Colostrinin in one-day-old chicks trained on a weak passive avoidance learning paradigm. Neurobiol Learn Mem 2006;86:66-71.…”

“…CLN is of particular interest in the field of neurodegeneration not only because it has in-vitro efficacy in preventing cellular degradative changes but also because it has been shown to have efficacy in improving performance on memory-related tasks in several animal systems [26,27] . CLN also increases the lifespan of the senescence-accelerated mouse (SAMP1), which is being used to study ageing and age-associated disorders [28,29] .…”