Enhancement of Interface Characteristics of Neural Probe Based on Graphene, ZnO Nanowires, and Conducting Polymer PEDOT

Ryu, Mingyu; Yang, Jae Hyuk; Ahn, Yumi; Sim, Minkyung; Lee, Kyung Hwa; Kim, Kyung-Soo; Lee, Taeju; Yoo, Sung Jin; Kim, So Yeun; Moon, Cheil; Je, Minkyu; Choi, Ji-Woong; Lee, Youngu; Jang, Jae Eun

doi:10.1021/acsami.7b02975

Cited by 54 publications

(52 citation statements)

References 51 publications

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“…Ryu et al of the Daegu Gyeongbuk Institute of Science and Technology demonstrated a neural probe structure based on graphene, ZnO nanowires, and conducting polymer that provides flexibility and low impedance performance [ 87 ]. As shown in Figure 6 f, the hybrid Au and graphene structure was utilized to achieve both flexibility and good conductivity.…”

Section: Research Progressmentioning

confidence: 99%

“… Research progress of the electrode-tissue interface modification technology of flexible MEMS microelectrodes for neural interface. ( a ) PEDOT/PSS composite film, reprinted from [ 3 ] with permission of Elsevier, Copyright 2002; ( b ) PEDOT/biomolecules composite film, reprinted from [ 83 ] with permission of Springer, Copyright 2008; ( c ) PEDOT/carbon nanotube (CNT) composite film, reprinted from [ 80 ] with permission of Elsevier, Copyright 2011; ( d ) PEDOT composite nanotubes, reprinted from [ 73 ] with permission of John Wiley and Sons, Copyright 2009; ( e ) PEDOT/graphene oxide (GO) composite film, reprinted from [ 84 ] with permission of Elsevier, Copyright 2013; ( f ) PEDOT-Au-ZnO nanowires, reprinted from [ 87 ] with American Chemistry Society, Copyright 2017. …”

Section: Figurementioning

confidence: 99%

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Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

et al. 2017

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With the rapid development of Micro-electro-mechanical Systems (MEMS) fabrication technologies, many microelectrodes with various structures and functions have been designed and fabricated for applications in biomedical research, diagnosis and treatment through electrical stimulation and electrophysiological signal recording. The flexible MEMS microelectrodes exhibit excellent characteristics in many aspects beyond stiff microelectrodes based on silicon or metal, including: lighter weight, smaller volume, better conforming to neural tissue and lower fabrication cost. In this paper, we reviewed the key technologies in flexible MEMS microelectrodes for neural interface in recent years, including: design and fabrication technology, flexible MEMS microelectrodes with fluidic channels and electrode–tissue interface modification technology for performance improvement. Furthermore, the future directions of flexible MEMS microelectrodes for neural interface were described, including transparent and stretchable microelectrodes integrated with multi-functional aspects and next-generation electrode–tissue interface modifications, which facilitated electrode efficacy and safety during implantation. Finally, we predict that the relationships between micro fabrication techniques, and biomedical engineering and nanotechnology represented by flexible MEMS microelectrodes for neural interface, will open a new gate to better understanding the neural system and brain diseases.

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Section: Research Progressmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

et al. 2017

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“…[5] In this line, a series of flexible electrodes have been proposed, [18][19][20] but only a few combine flexibility with nanostructure. [21,22,23] For instance, Rogers and colleagues described a bio-interfaced system based on ultrathin electronics supported by bioresorbable substrates of silk fibroin, [18] which assures minimal stresses on the tissue and highly conformal coverage. Authors proved the utility of these interfaces to record neural activity in the feline visual cortex.…”

Section: Introductionmentioning

confidence: 99%

“…[22] On the basis of hydrothermally grown ZnO NWs over a metalized polyimide layer, Ryu et al described stable flexible neural probes with low impedance after a two steps coating process with gold and PEDOT. [23] So, in order to achieve flexibility, either non-metallic solutions are used, at the cost of an increase in impedance, or a many-step growth process is required to finally metalize the sample.…”

Section: Introductionmentioning

confidence: 99%

Interfacing Neurons with Nanostructured Electrodes Modulates Synaptic Circuit Features

et al. 2020

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Understanding neural physiopathology requires advances in nanotechnology‐based interfaces, engineered to monitor the functional state of mammalian nervous cells. Such interfaces typically contain nanometer‐size features for stimulation and recording as in cell‐non‐invasive extracellular microelectrode arrays. In such devices, it turns crucial to understand specific interactions of neural cells with physicochemical features of electrodes, which could be designed to optimize performance. Herein, versatile flexible nanostructured electrodes covered by arrays of metallic nanowires are fabricated and used to investigate the role of chemical composition and nanotopography on rat brain cells in vitro. By using Au and Ni as exemplary materials, nanostructure and chemical composition are demonstrated to play major roles in the interaction of neural cells with electrodes. Nanostructured devices are interfaced to rat embryonic cortical cells and postnatal hippocampal neurons forming synaptic circuits. It is shown that Au‐based electrodes behave similarly to controls. Contrarily, Ni‐based nanostructured electrodes increase cell survival, boost neuronal differentiation, and reduce glial cells with respect to flat counterparts. Nonetheless, Au‐based electrodes perform superiorly compared to Ni‐based ones. Under electrical stimulation, Au‐based nanostructured substrates evoke intracellular calcium dynamics compatible with neural networks activation. These studies highlight the opportunity for these electrodes to excite a silent neural network by direct neuronal membranes depolarization.

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“…flexible organic bioelectronics. [13][14][15][16] Recently, graphene and carbon nanotube (CNT) based electrodes gained considerable interest for neural and cardiac interfacing, [17][18][19][20][21] as well as implant coatings [22,23] and stem cell therapy. [24][25][26] Their high surface-to-volume ratio and enhanced electron transfer [27] dramatically lower electrode impedance, resulting in improved cell recording and stimulation.…”

Section: Introductionmentioning

confidence: 99%

3D Microstructured Carbon Nanotube Electrodes for Trapping and Recording Electrogenic Cells

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et al. 2017

Adv Funct Materials

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Electrogenic cells such as cardiomyocytes and neurons rely mainly on electrical signals for intercellular communication. Microelectrode array (MEA) devices have been developed to both record and stimulate electrogenic cell. This technology is fuels new insights in the operation of electrogenic cells and the operation of the brain, and is particularly suitable for long-term recording of cell signals under low cell stress conditions. To date, microelectrode arrays are relying on flat or needle shaped electrode surfaces, mainly due to limitations in the lithographic processes used to fabricate these electrodes. However, cells are intrinsically three-dimensional (3D), and this paper relies on a previously reported elasto-capillary aggregation process, to create 3D carbon nanotube (CNT) MEAs. We found that CNTs aggregated in well-shaped structures of similar size as cardiomyocytes are particularly interesting for MEA applications. This is because (i) CNT microwells of the right diameter preferentially trap individual cardiomyocytes , which facilitates single cell recording without the need for clamping pf cells or deconvolution of signals, and (ii) once the cells are trapped inside of the CNT wells, this 3D CNT structure is used as an electrode surrounding the cell, which increases the cell-electrode contact area and as a result we found that the recorded output voltages increase significantly(up to more than 200%). Further, our fabrication process allows for a large library of 3D geometries in a scalable fashion, which paves the way for future study of complex interactions between electrogenic cells and 3Drecording electrodes.

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Enhancement of Interface Characteristics of Neural Probe Based on Graphene, ZnO Nanowires, and Conducting Polymer PEDOT

Cited by 54 publications

References 51 publications

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

Interfacing Neurons with Nanostructured Electrodes Modulates Synaptic Circuit Features

3D Microstructured Carbon Nanotube Electrodes for Trapping and Recording Electrogenic Cells

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