Enhancement of inhibition rate of antibiotic against bacteria by molecularly imprinted nanoparticles targeting alarmone nucleotides as antibiotic adjuvants

Abstract

Antibiotic tolerance and resistance in bacteria have caused a great threaten to the humankind. Bacteria can rapidly accumulate alarmone nucleotides (guanosine tetra-, and pentaphosphate, usually denoted as (p)ppGpp) to repair...

Portable smartphone-enabled dydrogesterone sensors based on biomimetic polymers for personalized gynecological care

“…17,18 These sites offer target-specific geometrical as well as chemical fits, making molecular imprinting a highly competitive technique for producing artificial antibodies at a much-reduced cost for the recognition of biomolecules. 19 This feature makes MIPs a valuable and sought-after research material, as an alternative to natural antibodies or enzymes, used for various applications such as sensors, separations, and catalysis. [20][21][22] Unlike natural receptors, MIPs are easy to generate, are robust in extreme conditions, possess good long-term storage stability, and can be easily synthesized for a variety of targets without laborious laboratory work.…”

Role of (p)ppGpp in antibiotic resistance, tolerance, persistence and survival in Firmicutes

“…Thus, genetic disruption of vmIR or the (p)ppGpp synthesis pathway caused sensitivity to the pleuromutilin tiamulin, lincosamides such as the natural product lincomycin, as well as the more potent semi-synthetic antibiotic clindamycin, the recently developed fully synthetic iboxamycin, and the type A streptogramin virginiamycin M1 (Takada et al 2022 ). Moreover, specific binding of molecularly imprinted nanoparticles (MIP-NP) to (p)ppGpp led to a significant increase in antibiotic efficiency rates (kanamycin, oxytetracycline) both in E. coli and S. aureus (Chen et al 2022 ).…”