Enhancement of in vivo and in vitro T cell response against measles virus haemagglutinin after its incorporation into liposomes: effect of the phospholipid composition

Garnier, Florence; Forquet, Frédérique; Bertolino, Patrick; Gerlier, Denis

doi:10.1016/0264-410x(91)90061-a

Cited by 20 publications

(2 citation statements)

References 14 publications

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“…Lipid composition: The effect of selection of lipids on liposomal properties, such as particle size, stability, and ability of inducing maturation of DCs, is a prerequisite in order to achieve an optimized vaccine carrier. The effect of lipid composition on membrane fluidity has been studied using gel-liquid transition temperature and membrane phase behavior experiments [ 58 , 59 , 60 , 61 , 62 ]. The selection of a lipid determines membrane fluidity, which is linked to cellular trafficking and antigen presentation to APCs.…”

Section: Liposomesmentioning

confidence: 99%

Recent Advances in Subunit Vaccine Carriers

2016

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The lower immunogenicity of synthetic subunit antigens, compared to live attenuated vaccines, is being addressed with improved vaccine carriers. Recent reports indicate that the physio-chemical properties of these carriers can be altered to achieve optimal antigen presentation, endosomal escape, particle bio-distribution, and cellular trafficking. The carriers can be modified with various antigens and ligands for dendritic cells targeting. They can also be modified with adjuvants, either covalently or entrapped in the matrix, to improve cellular and humoral immune responses against the antigen. As a result, these multi-functional carrier systems are being explored for use in active immunotherapy against cancer and infectious diseases. Advancing technology, improved analytical methods, and use of computational methodology have also contributed to the development of subunit vaccine carriers. This review details recent breakthroughs in the design of nano-particulate vaccine carriers, including liposomes, polymeric nanoparticles, and inorganic nanoparticles.

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Section: Liposomesmentioning

confidence: 99%

Recent Advances in Subunit Vaccine Carriers

2016

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“…As the B cell response to viral antigens requires T cell help, studies on the optimal conditions for helper specificity are important for design of a subunit vaccine. It has been shown in several studies that H and F proteins of MV are potent T cell antigens and that the immunogenicity can be greatly improved by insertion of the proteins into liposomes [46][47][48]. In a recent study, recombinant vaccinia virus expressing individual N, H, F, M or P protein were used to study the role of each protein in protection of rats from measles encephalitis [49].…”

Section: Specificity Of the Cell-mediated Immunity-proliferation Respmentioning

confidence: 99%

Antibody and T cell responses to measles virus polypeptides and synthetic peptides

Mäkelä

Ilonen

Salmi

1993

FEMS Immunology &Amp; Medical Microbiology

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Recent Advances in Particulate Adjuvants for Cancer Vaccination

Wang

et al. 2019

Advanced Therapeutics

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By activating/stimulating antigen-presenting cells (APCs) and efficiently inducing humoral or cellular immune responses, particulate adjuvants have become one of the most ambitious and promising strategies in cancer vaccination. A large number of materials have been studied for their use as particulate adjuvants, including inorganic materials, polymeric materials, liposomes, emulsions, and exosomes. According to their unique physicochemical properties, these particulate adjuvants mainly work in three aspects: antigen delivery, APC activation, and antigen cross-presentation, and they show great promise in various antitumor applications. This progress report highlights the recent advances in the study of particulate adjuvants, ranging from their materials, functions, and physicochemical properties to their applications in cancer vaccination.

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Enhancement of in vivo and in vitro T cell response against measles virus haemagglutinin after its incorporation into liposomes: effect of the phospholipid composition

Cited by 20 publications

References 14 publications

Recent Advances in Subunit Vaccine Carriers

Recent Advances in Subunit Vaccine Carriers

Antibody and T cell responses to measles virus polypeptides and synthetic peptides

Recent Advances in Particulate Adjuvants for Cancer Vaccination

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